Emergency BU Alert Boston University's Charles River and Medical Center Campuses will be closed all day Tuesday, January 27, 2015. BU Medical Campus CLOSED Tuesday, Jan. 27, 2015 Boston University Medical Campus will be closed Tuesday, Jan. 27. All normal academic and administrative activities have been canceled. Employees in essential services should report as scheduled. Essential services include, but are not limited to Public Safety, Facilities Management, Emergency Patient Treatment, Office of Environmental Health and Safety, Occupational and Environmental Medicine, and Mail Service. Medical, PA and GMS students who are assigned to inpatient services or clinics are expected to be present, if possible. Students who are assigned to outpatient services should check with their course directors or the policy at the clinical site. For the very latest information, please go to BU Today at http://www.bu.edu/today and the Emergency Communications page at http://www.bu.edu/ehs/comm

Modern Instrumental Biochemistry

Modern biological research uses both the traditional techniques of gel electrophoresis, western blots and protein sequencing via Edman degradation, as well as the newer instrumentation intensive techniques of high performance chromatography, nuclear magnetic resonance, X-ray crystallography, and mass spectrometry. These new instrumentation intensive techniques have made possible the growing array of sophisticated projects such as the Human Genome Project (made possible by rugged, high performance capillary electrophoretic chromatography) and the vast number and improved quality of protein 3D structures now available (made possible by improved crystallographic and NMR methods). The current growth field in instrumental biochemistry is the field known as “Proteomics”.

Mass Spectrometry is the primary enabling technology for the burgeoning field of instrumental biology. The core development that is driving “Proteomics” is improvements in the sensitivity, automation, resolution, sample handling protocols, and mass accuracy of the mass spectrometers. The goal of our research group is to develop and improve the needed mass spectrometry instrumentation with an eye toward applications of biological and medical interest.

Among mass spectrometers, the Fourier Transform Mass Spectrometer (FTMS) is universally regarded as superior to other mass spectrometers in resolving power, mass accuracy, sensitivity, and flexibility. However, the development of this crucial instrumentation has lagged behind many other instruments due to the perceived complexity. Many fundamental developments have yet to be made and applied in FTMS.

 

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