Yiqun Huang, Postdoctoral Associate
Mass Spectrometry Resource
Department of Biochemistry
Boston University School of Medicine
670 Albany Street, Suite 504
Boston, MA 02118
Yiqun’s current research activities include:
1) Mechanistic studies on the fragmentation behavior of biomolecules, especially metal-bound oligosaccharides, by electron activated dissociation (ExD) methods, e.g. electron capture dissociation (ECD) and electronic excitation dissociation (EED). Advanced computational chemistry tools, including quantum mechanical methodology and molecular dynamics (MD) simulations are extensively utilized to reveal the nature of these ExD processes.
2) Theoretical modeling to aid the ion mobility spectrometry (IMS)-MS analysis of biomolecules, particularly for isomer differentiation. MD simulations coupled with annealing techniques are used for conformation space exploration, which, together with collisional cross section calculations, can be used to establish the relationship between the geometric characters of target molecules and their ion-mobility properties.