Vyacheslav Labunskyy, PhD

Version 2

Assistant Professor of Dermatology

Boston University School of Medicine

Administrative Office

Boston University School of Medicine, Dept of Dermatology

609 Albany Street, Boston, MA 02118
Tel: 617-638-5551
Fax: 614-638-5515

 

Education

2002 BS/MS Biochemistry, summa cum laude, Donetsk National University, Donetsk, Ukraine
2008 PhD Biochemistry, University of Nebraska, Lincoln, NE
2009-2014 Postdoctoral Fellow Brigham &Women’s Hospital, Harvard Medical School, Boston, MA

Research Interests

  • Molecular Mechanisms of Aging
  • Functional Genomics
  • Stress Signaling
  • Synthetic Biology

Summary

The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress-response signaling regulates aging.  In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.

We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.

Selected Publications

  1. Lorusso JS, Sviderskiy OA, and Labunskyy VM. (2017) Emerging omics approaches in aging research. Antioxid Redox Signal, doi: 10.1089/ars.2017.7163. PMID: 28874057
  2. Beaupere C, Chen RB, Pelosi W, and Labunskyy VM. (2017) Genome-wide quantification of translation in budding yeast by ribosome profiling. J Vis Exp – In press
  3. Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, and Labunskyy VM. (2017) CAN1 arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes. Cell Reports, 18, 1884-1892. PMID: 28228255
  4. Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. (2016) N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev, 30, 2404-2416. PMID: 27881602
  5. Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, and Gladyshev VN. (2014) Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet, 10, e1004019. PMID: 24391512
  6. Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. (2014) The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda)  4, 1183-1191. PMID: 24776987
  7. Labunskyy VM, Hatfield DL, and Gladyshev VN. (2014) Selenoproteins: molecular pathways and physiological roles. Physiol Rev 94, 739-777. PMID: 24987004