Clinical Epidemiology Research & Training Unit


Under the direction of Dr. David T. Felson, MD, MPH, the Clinical Epidemiology Research and Training Unit began operations on October 1, 2001. The Unit’s mission is to perform and promote high-quality research using clinical epidemiologic methods to answer questions about the causes of, and therapy for, disease and disability. There may be a focus on musculoskeletal diseases, but the mission also extends to other diseases. The Unit’s goals are to train students at various levels and in various disciplines who wish to enter academically-based careers in clinical epidemiology, as well as to advance the statistical, epidemiological, and clinical epidemiological methods used to address clinical research questions. In addition, Unit faculty members strive to develop the Internet as a tool to perform clinical research and foster scientific collaborations both within and outside Boston University.

The Unit has over $10 million in federal grants and contracts supporting research. Most of the Unit’s funding is from the National Institutes of Health (NIH), including a Multidisciplinary Clinical Research Center (MCRC). This funding allows the Unit to be constituted as a multidisciplinary team, including doctoral non-physician level investigators who bring methodological expertise to clinical research questions.

The spectrum of research conducted in Clinical Epidemiology is broad and includes:

1. An internet-based case crossover study of gout
2. Large multicenter cohort studies of osteoarthritis
3. Studies of work disability prevention
4. Pharmacoepidemiology studies using the THIN database from the UK (the Unit is the local home for
this database, which can be used by others in the BU community) and from the VA
5. Gene-wide association studies of pain and gout
6. Studies of function loss and disability in elders
7. Studies of outcome measurement in rheumatoid arthritis
8. Evaluations of methodologic approaches in progression/outcomes studies
9. Biomarker studies in vasculitis


The Unit’s primary missions are in research and training, with clinical activity constituting a secondary activity. Nonetheless, Drs. Felson, Neogi, Misra, and Dubreuil remain actively involved in clinical medicine.


Dr. Felson directs the CREST (Clinical Research Training) Program now under the auspices of the Training and Education Function of the CTSI.  Since its inception in 1999 as a K30, the CREST Program has trained and mentored fellows and junior faculty interested in pursuing clinical research careers. The primary components of the CREST program at BUSM include a biweekly seminar, research and career mentoring, an IRB internship and course work leading to an advanced degree at BUSPH and BUSM’s MACI Program.  Students with a doctoral degree in the health sciences (M.D, D.D.S., D.M.D., or Ph.D.) are eligible to apply to the CREST program for comprehensive training in clinical research including epidemiology, clinical epidemiology, health services research, biobehavioral research and translational research.  See our CREST Program link for more information.

In addition to administering the CREST Program, the Unit has undertaken direct, on-site training of fellows whose research interests parallel those of the Unit’s investigators.  This has included fellows in geriatrics and rheumatology, as well as epidemiology doctoral students.

Clin Epi


Primary teaching affiliate
of BU School of Medicine