Jeffrey Samet, Grant Support

NIDA R25-DA033211                         (Samet/O’Connor Co-PIs)                              4/01/12-3/31/17

Advancing Clinical Research Training within Addiction Residency Programs

The objective of this grant is to develop a Research in Addiction Medicine Scholars (RAMS) Program.  The RAMS Program is significant because it will expand the nation’s research capacity among trainees in the new medical specialty of Addiction Medicine.  This seeks ultimately to improve patient care by increasing knowledge about effective prevention and treatment in order to reduce the medical, social, and financial burden of drug abuse and addiction.

NIAAA U01-AA021989                       (Samet/Freiberg Co-PIs)                                9/01/12-8/31/17

Zinc for HIV Disease among Alcohol Users – An RCT in the Russia ARCH Cohort

This double-blinded randomized controlled trial will assess the efficacy of zinc supplementation

vs. placebo among 250 HIV-infected Russians, who are ART-naïve at enrollment and have a recent history of heavy drinking. Role: PI

NIAAA U24-AA020778                       (Samet, PI)                                                     9/20/11-8/31/16

Administrative Coordinating Core – URBAN ARCH Consortium

The central goal of the URBAN ARCH Consortium is to examine the consequences of alcohol on HIV disease and to mitigate its harmful effects. The Administrative Coordinating Core will ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness. Role: PI

NIAAA U01-AA020780                       (Samet, PI)                                                     9/20/11-8/31/16

Alcohol and Zinc Impact on Inflammatory Markers in HIV Disease – Russia ARCH Cohort

In the Russia ARCH Cohort we will examine a cohort of HIV-infected heavy drinkers to determine alcohol’s impact on biomarkers reflecting microbial translocation. Role: PI

NIAAA U01-AA020776                       (Hahn, PI)                                                       9/20/11-8/31/16

Impact of Heavy Alcohol Use on Pre-ART HIV Disease – Uganda ARCH Cohort

This is a 650-person prospective cohort study to determine the effect of heavy alcohol consumption on HIV disease progression prior to the start of antiretroviral therapy.  Role: Co-investigator

NIAAA U01-AA11003                         (Saitz, PI)                                                        9/20/11-8/31/16

Addressing Alcohol/HIV Consequences in Substance Dependence – Boston ARCH Cohort

In the Boston ARCH Cohort, we accurately characterize alcohol use and consequences in people with HIV infection affected by multiple substances, look prospectively at impact on bone health, and implement a clinical trial. Role: Co-investigator

NIAAA R25-AA020480                       (Blondell/Samet, Co-PIs)                                9/10/11-8/31/13

National Infrastructure for Translating Addiction Research into Clinical Practice

The goals of this grant are to establish a National Addiction Medicine Residency Assistance Council (NAMRAC), to identify and support Model Residency Programs, to disseminate curricula, and to recruit new members to NAMRAC.  Role: Co-PI

NIDA  R01-DA032082                        (Samet, PI)                                                     7/15/11- 4/30/16

Linking Russian Narcology & HIV Care to Enhance Treatment, Retention, & Outcomes (LINC)

The study’s goal is to improve upon current seek, test, treat, and retain efforts for HIV-infected Russian and Eastern European IDUs in narcology care, a group routinely tested for HIV. Role:  PI

NIDA  R25-DA13582                          (Samet, PI)                                                     5/01/01-4/30/16

Clinical Addiction Research and Education (CARE) Program

The major aims of this grant are to develop generalist physician drug abuse researchers, train chief residents in generalist physician disciplines about addiction to facilitate their teaching of physicians in training, and develop an on-line drug abuse literature review newsletter. Role:  PI

NIAAA  R01-AA016059                      (Samet, PI)                                                     9/30/06-8/31/13 (NCE)

Maximizing Opportunity – HIV Prevention in Hospitalized Russian Drinkers

The objective of this grant, HERMITAGE (HIV’s Evolution in Russia – Mitigating Infection Transmission and Alcoholism in a Growing Epidemic) is to test in a randomized controlled trial the effectiveness of a modified US HIV secondary prevention program, Healthy Relationships Intervention in risky Russian drinkers. Role: PI

NIDA R01-DA10019                           (Samet, PI)                                                     9/30/96-3/31/13 (NCE)

Enhanced Linkage of Drug Abusers to Primary Medical Care

The purpose of this study is to test the effectiveness of a primary care-based disease management program for drug dependence. Role:  PI

NIDA R01 DA025068                        (Saitz, PI)                                                        7/15/08-4/30/13

Efficacy/Effectiveness of Unhealthy Drug Use Screening/Brief Intervention Models

The objective of this study, the Assessing Screening Plus brief Intervention’s Resulting Efficacy to stop drug use (ASPIRE) Study, is to determine the efficacy of two models of brief intervention for decreasing drug use and consequences in primary care patients. Role:  Co-investigator

NIDA  K23-DA027367                        (Tsui, PI)                                                         4/01/10-3/31/14

HCV and Pain in Substance Users With and Without HIV

This is a patient oriented clinical research career development award. Role:  Primary Mentor

NIDA K23-DA031612                         (Morse, PI)                                                      2/15/12-1/31/17

Supporting Health In Drug Treatment Court for Women with HIV or Hepatitis C

The purpose of this career development grant is to enhance patient-oriented research by addressing theory-based motivation mechanisms for drug-using women in criminal justice settings to engage in HIV and HCV-related services. Role: Secondary Mentor