STRAP PTM

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STRAP PTM: Software for the Differential Comparison of PTMs

STRAP PTM (Software Tool for Rapid Annotation of Proteins: Post-Translational Modification edition) is a software program developed at the Cardiovascular Proteomics Center of Boston University School of Medicine (Boston, MA). The program characterizes PTM (post-translational modification) changes in large proteomic data sets obtained from liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments.

STRAP PTM uses spectral counting and a novel scoring algorithm to accelerate the identification of differential PTMs through easy-to-use GUIs for setup and analysis. The program collates large data sets from two or more sample groups, identifies peptides with PTMs, and sorts and tallies the peptides and PTMs for comparison by protein and by group. STRAP PTM applies a unique, multi-component score to the PTMs for ranking at the amino acid, peptide, and protein levels. The results of STRAP PTM analysis are clearly visualized in many interactive tables and maps.

Hardware Requirements

  • PC with Windows 7 or 8
  • At least 4 GB RAM (8 GB RAM preferable)
  • Internet connection

Input Requirements

  • Internet access to the Unimod database
  • Access to a database of protein sequences in FASTA format (e.g., UniProtKB)

Example of Results Page

ResultsPage

Download Software and Sample Files

Please select Download for the STRAP PTM program (version 1.0 beta) and the STRAP PTM tutorial sample files.

Tutorial

Please select Tutorial for the STRAP PTM tutorial.

Quick Start

Please select Quick Start for a basic guide in using STRAP PTM.

News

Please select News for up-to-date information about STRAP PTM.

Contact Us

Please select Contact Us for assistance with any STRAP PTM problems.

Disclaimer

STRAP PTM software was developed at the Cardiovascular Proteomics Center of Boston University School of Medicine (Boston, MA). The program (version 1.0 beta) is freely available for external testing. We assume no responsibility for its use, and we make no guarantees, whether expressed or implied, about its performance or any other characteristic. We would appreciate acknowledgment of our organization if the software is used.

References

Primary teaching affiliate
of BU School of Medicine