Susan E. Leeman, PhD

Professor, Pharmacology & Experimental Therapeutics

Susan Leeman
(617) 638-4364
72 E. Concord St Building A

Biography

Dr. Susan Leeman is a Professor in the Department of Pharmacology & Experimental Therapeutics, and the Director of the Neuropeptide Laboratory in the Pharmacology Department at the Boston University School of Medicine. Dr. Leeman has been a Member of the National Academy of Sciences since 1991.

Dr. Leeman’s research focuses on the two peptides, substance P (SP) and neurotensin, that were isolated and chemically defined in this laboratory. Previous projects that are currently underway relating to the biochemistry and pharmacology of SP include studies to determine the binding domains of SP with its receptor using photoactivatable derivatives of SP containing the photoreactive amino acid benzoylphenlalanine; studies to determine the binding domains of an antagonist of SP, CP 96,345 using a photoactivatable derivative of this compound; the characterization of calcium signals generated by administration of SP to CHO cells transfected with mRNA encoding the full-length SP receptor; the roles of SP in several models of inflammation in the gastrointestinal tract using non-peptide SP antagonists; a truncated form of the SP receptor and several mutant receptors. A new direction of research involves studies directed towards the chemical characterization and function of the carbohydrate moieties on the SP receptor.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences

Education

  • Radcliffe College, PhD
  • Radcliffe College, MA
  • Goucher College, BA

Publications

  • Published on 11/6/2017

    Theoharides TC, Taracanova A, Tsilioni I, Conti P, Leeman SE. Reply to Fattori et al.: Action of SP and IL-33 on mast cells. Proc Natl Acad Sci U S A. 2017 Nov 06. PMID: 29109296.

    Read at: PubMed
  • Published on 5/1/2017

    Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):E4002-E4009. PMID: 28461492.

    Read at: PubMed
  • Published on 9/23/2016

    Patel AB, Tsilioni I, Leeman SE, Theoharides TC. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci U S A. 2016 Sep 23. PMID: 27663735.

    Read at: PubMed
  • Published on 12/9/2013

    Yuan H, Zelka S, Burkatovskaya M, Gupte R, Leeman SE, Amar S. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5059-68. PMID: 24324141.

    Read at: PubMed
  • Published on 11/11/2013

    Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19567-72. PMID: 24218590.

    Read at: PubMed
  • Published on 8/5/2013

    Amar S, Leeman S. Periodontal innate immune mechanisms relevant to obesity. Mol Oral Microbiol. 2013 Oct; 28(5):331-41. PMID: 23911141.

    Read at: PubMed
  • Published on 12/24/2012

    Bhargava A, Clifton MS, Mhaske P, Mhsake P, Liao M, Pothoulakis C, Leeman SE, Grady EF. Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):731-6. PMID: 23267070.

    Read at: PubMed
  • Published on 8/23/2012

    Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF. Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. J Crohns Colitis. 2013 Jun; 7(5):403-11. PMID: 22921465.

    Read at: PubMed
  • Published on 12/12/2011

    Merrill JC, You J, Constable C, Leeman SE, Amar S. Whole-body deletion of LPS-induced TNF-a factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21247-52. PMID: 22160695.

    Read at: PubMed
  • Published on 10/3/2011

    Gillespie E, Leeman SE, Watts LA, Coukos JA, O'Brien MJ, Cerda SR, Farraye FA, Stucchi AF, Becker JM. Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17420-5. PMID: 21969570.

    Read at: PubMed

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