Paul A. Monach, MD, PhD

Associate Professor, Medicine

Paul Monach
617.414.2503
75 E. Newton St Evans Building

Biography

My research is focused on clinical and translational research in vasculitis: biomarkers, genetics, and clinical trials.

I have led studies aimed at identifying new markers that could improve diagnosis, staging, assessment of current disease activity, and predicting the future course of disease, using proteins detectable in the blood or urine and gene expression profiles in blood cells.

I have also led candidate genes studies in vasculitis and has been involved in the planning and recruitment for genome-wide association studies in multiple forms of vasculitis.

I have participated in most multi-center clinical trials conducted over the past 10 years in the US, in various vasculitides.

This work has been conducted through NIH-funded consortia: the Vasculitis Clinical Research Consortium and the RAVE/ITN Study Group. In addition, I have been a member of the Immunological Genome Project Consortium and contributed data on gene expression in mouse neutrophils to that effort.

Education

  • University of Chicago, MD
  • University of Chicago, PhD
  • Harvard University, AB

Publications

  • Published on 4/1/2018

    Cornec D, Kabat BF, Mills JR, Cheu M, Hummel AM, Schroeder DR, Cascino MD, Brunetta P, Murray DL, Snyder MR, Fervenza F, Hoffman GS, Kallenberg CGM, Langford CA, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Stone JH, Barnidge DR, Specks U. Pharmacokinetics of rituximab and clinical outcomes in patients with anti-neutrophil cytoplasmic antibody associated vasculitis. Rheumatology (Oxford). 2018 Apr 01; 57(4):639-650. PMID: 29340623.

    Read at: PubMed
  • Published on 2/22/2018

    Springer JM, Monach P, Cuthbertson D, Carette S, Khalidi NA, McAlear CA, Pagnoux C, Seo P, Warrington KJ, Ytterberg SR, Hoffman G, Langford C, Hamilton T, Foell D, Vogl T, Holzinger D, Merkel PA, Roth J, Hajj-Ali RA. Serum S100 Proteins as a Marker of Disease Activity in Large Vessel Vasculitis. J Clin Rheumatol. 2018 Feb 22. PMID: 29470262.

    Read at: PubMed
  • Published on 2/1/2018

    Kermani TA, Sreih AG, Cuthbertson D, Carette S, Hoffman GS, Khalidi NA, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland L, Pagnoux C, Seo P, Warrington KJ, Ytterberg SR, Merkel PA. Evaluation of damage in giant cell arteritis. Rheumatology (Oxford). 2018 Feb 01; 57(2):322-328. PMID: 29112740.

    Read at: PubMed
  • Published on 1/25/2018

    Rhee RL, Davis JC, Ding L, Fervenza FC, Hoffman GS, Kallenberg CGM, Langford CA, McCune WJ, Monach PA, Seo P, Spiera R, St Clair EW, Specks U, Stone JH, Merkel PA. The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. Clin J Am Soc Nephrol. 2018 Feb 07; 13(2):251-257. PMID: 29371340.

    Read at: PubMed
  • Published on 9/8/2017

    Geetha D, Sethi S, De Vriese AS, Specks U, Kallenberg CGM, Lim N, Spiera R, St Clair EW, Merkel PA, Seo P, Monach PA, Lepori N, Fessler BJ, Langford CA, Hoffman GS, Sharma R, Stone JH, Fervenza FC. Interstitial Immunostaining and Renal Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis. Am J Nephrol. 2017; 46(3):231-238. PMID: 28881339.

    Read at: PubMed
  • Published on 7/1/2017

    Wallace ZS, Miloslavsky EM, Cascino M, Unizony SH, Lu N, Hoffman GS, Kallenberg CGM, Langford CA, Merkel PA, Monach PA, Seo P, Spiera R, St Clair EW, Specks U, Brunetta P, Choi HK, Stone JH. Effect of Disease Activity, Glucocorticoid Exposure, and Rituximab on Body Composition During Induction Treatment of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Care Res (Hoboken). 2017 Jul; 69(7):1004-1010. PMID: 27696762.

    Read at: PubMed
  • Published on 4/6/2017

    Merkel PA, Xie G, Monach PA, Ji X, Ciavatta DJ, Byun J, Pinder BD, Zhao A, Zhang J, Tadesse Y, Qian D, Weirauch M, Nair R, Tsoi A, Pagnoux C, Carette S, Chung S, Cuthbertson D, Davis JC, Dellaripa PF, Forbess L, Gewurz-Singer O, Hoffman GS, Khalidi N, Koening C, Langford CA, Mahr AD, McAlear C, Moreland L, Seo EP, Specks U, Spiera RF, Sreih A, St Clair EW, Stone JH, Ytterberg SR, Elder JT, Qu J, Ochi T, Hirano N, Edberg JC, Falk RJ, Amos CI, Siminovitch KA. Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol. 2017 May; 69(5):1054-1066. PMID: 28029757.

    Read at: PubMed
  • Published on 4/4/2017

    Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 01; 127(5):1714-1724. PMID: 28375155.

    Read at: PubMed
  • Published on 3/28/2017

    Monach PA. Assessing Performance of Internal Medicine Residents. JAMA. 2017 03 28; 317(12):1276-1277. PMID: 28350919.

    Read at: PubMed
  • Published on 3/8/2017

    Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, Seo P, Moreland LW, Weisman M, Koening CL, Sreih AG, Spiera R, McAlear CA, Warrington KJ, Pagnoux C, McKinnon K, Forbess LJ, Hoffman GS, Borchin R, Krischer JP, Merkel PA. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Takayasu Arteritis. Arthritis Rheumatol. 2017 Apr; 69(4):846-853. PMID: 28133931.

    Read at: PubMed

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