Joseph Macon Keane, MD
Adjunct Assistant Professor, Medicine
Biography
Joseph Keane is a Consultant Respiratory Physician in St. James’s Hospital, and Associate Professor of Medicine in Trinity College. He completed a clinical and research post-doctoral fellowship in Pulmonary and Critical Care Medicine at Chobanian and Avedisian School of Medicine.
Prof Keane’s research interests include the host immune response to tuberculosis; and developing improved diagnostic tests for this disease. His NEJM article on the association of TB reactivation and the use of TNF blockers is the most cited tuberculosis paper of the last 10 years. He is the director of the TB service in St. James’s Hospital, which is the designated supra-regional center for tuberculosis.
The Health Research Board, Science Foundation Ireland, and the Royal City of Dublin Hospital Trust fund Prof Keane’s research.
Prof Keane was the recipient of the Inaugural William Stokes Award in September 2011 in recognition of his research activities.
Education
- Trinity College, MBBCh
- Trinity College, DM
- Trinity College, BA
Publications
- Published on 8/16/2021
O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP. An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis. J Vis Exp. 2021 08 16; (174). PMID: 34459817.
Read at: PubMed - Published on 10/29/2018
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA. Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection. Eur J Pharm Biopharm. 2019 Jan; 134:153-165. PMID: 30385419.
Read at: PubMed - Published on 2/12/2018
Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG. Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells. Oncoimmunology. 2018; 7(6):e1428156. PMID: 29872551.
Read at: PubMed - Published on 1/15/2017
Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017 Jan 15; 64(2):111-115. PMID: 28052967.
Read at: PubMed - Published on 12/8/2016
Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017 Jan 15; 64(2):e1-e33. PMID: 27932390.
Read at: PubMed - Published on 2/19/2016
Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP. Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing. PLoS One. 2016; 11(2):e0149167. PMID: 26894562.
Read at: PubMed - Published on 2/12/2016
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J. Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication. J Immunol. 2016 Mar 15; 196(6):2444-9. PMID: 26873991.
Read at: PubMed - Published on 9/1/2015
Gleeson LE, Keane J. First Steps in Biomarker Assessment for Reactivation Risk in Latent Tuberculosis Infection. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):534-5. PMID: 26325153.
Read at: PubMed - Published on 12/15/2014
O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J. Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):1430-6. PMID: 25390734.
Read at: PubMed - Published on 5/6/2013
Doherty AM, Kelly J, McDonald C, O'Dywer AM, Keane J, Cooney J. A review of the interplay between tuberculosis and mental health. Gen Hosp Psychiatry. 2013 Jul-Aug; 35(4):398-406. PMID: 23660587.
Read at: PubMed
View 8 more publications: View full profile at BUMC