1. PROSPECTIVE RESEARCH:
a) Retrospective Review of Long Term Voice Quality Following Augmentation of the Vocal Fold with Cymetra Using the Minihole Laryngoplasty Technique. IRB approval obtained this year. Chart review in progress.
b) Feasibility of Using Manual Robotic Instrumentation for Microlaryngeal Surgery. The objective of this study is to evaluate effectiveness of a proprietary robotic instrument for use in microlaryngeal surgery. The first phase of this study will utilize a larynx model/mannequin. Subsequent phases will utilize animal and cadaver models. Study is in initial stage of planning.
c) Use of the DaVinci Robotic System in Pharyngeal and Laryngeal Endoscopic Surgery. The object of this study is to evaluate the usefulness of the DaVinci robotic system in performing endoscopic pharyngeal and laryngeal surgery. Currently such procedures are carried out using conventional endoscopic instrumentation. We are in the process of submitting IRB application.
d) Phase 2, Open-label Trial of the Safety and Biological Effect of Pre-operative Peri-lymphatic Ultralow Dose IRX-2 (with Cyclophosphamide, Indomethacin, and Zinc) in Patients with Resectable Cancer of the Head and Neck. This study is in initial planning stage.
2. FUNDED RESEARCH:
a) Spectroscopic Imaging and Diagnosis of Neoplasia
Source: National Institutes of Health (NCI) – 1R01CA097966
P.I.: Gregory Grillone, M.D., F.A.C.S.
This study is the basis of my triologic thesis. The objectives of this research are to develop and test a spectroscopic based algorithm for the evaluation of cancer or pre-cancerous changes in oral cavity epithelium. An in depth study of this approach is being carried out in the oral cavity as well as for a data set previously collected from the esophagus. This study is being carried out in collaboration with the spectroscopy laboratory at MIT. They have developed a portable, clinical device known as the Fast Excitation Emission Matrix (Fast-EEM), which collects reflectance and fluorescence spectra. This instrument is being used to collect spectroscopic data prior to biopsy of oral cavity lesions in patients with suspicious lesions of the oral cavity.
b) Laser Atraumatic Treatment of Ectasias on Vocal Cords
Source: National Institutes of Health (NIDCD) – 1R21DC006853001
PI: Zimmern Wang, M.D.
Our previous studies have shown the efficacy and safety of PDL as an alternative to routine surgeries (that result in more scarring) for treatment of laryngeal papilloma. Specific aims are (1) to further optimize PDL parameters in the cheek pouches of a hamster model; (2) to compare the treatment selectivity and safety between CO2 laser and PDL microvascular targeting (MVT) treatment, in the same model; and (3) to determine whether PDL will produce better and quicker voice improvement than the CO2 laser, in 12 patients with vocal fold small vascular lesions (ectasias).
c) Voice Preserving Treatment of Recurrent Laryngeal Papilloma (RLP)
Source: National Institutes of Health (NIDCD) – 1R01DC006617
P.I. Zimmern Wang, M.D.
This study is a continuation of our effort to develop a new, low cost and less invasive alternative to the currently traumatic surgeries for RLP. Our final objective is to provide a “voice preserving” and long-term effective therapy for RLP that can be delivered in the putpatient setting. This 2 year study will evaluate 30 adults with RLP, using traditional CO2 laser in 15 cases and new PDL-Celecoxib treatment in other 15 cases.
d) Voice Preserving Treatment of Laryngeal Papilloma in Children
Source: National Institutes of Health (NIDCD) – 1R01DC008287
P.I. Zimmern Wang, M.D.
e) Prediction of Cancer Chemoprevention Efficacy with Cell Imaging
Source: National Institutes of Health (NCI) – 1R21CA
P.I. Zimmern Wang, M.D.
f) Harvard Collaborative Oral Cancer Study
Source: National Institutes of Health – Grant #CA 78609
P.I.: Karl T. Kelsey, M.D., M.O.H.,
Site P.I.: Gregory Grillone, M.D., F.A.C.S.
g) Long-term General and Voice Related Quality of Life after Botulinum Toxin Injection for Adductor Spasmodic Dysphonia
Source: Alpha Omega Honor Society
P.I. Gregory A. Grillone, M.D., F.A.C.S.
- M. Stuart Strong and Charles W. Vaughan Professor, Otolaryngology-Head & Neck Surgery, Boston University School of Medicine
- Chief, Otolaryngology-Head & Neck Surgery, Boston Medical Center
- Active Staff Privileges, Surgery, Boston Medical Center
- Mount Sinai School of Medicine, MD
- New York University, BA
- Published on 10/8/2017
Kamran SC, Qureshi MM, Jalisi S, Salama A, Grillone G, Truong MT. Primary surgery-versus primary radiation-based treatment for locally advanced oropharyngeal cancer. Laryngoscope. 2017 Oct 08. PMID: 28988426.
- Published on 9/1/2017
Crimlisk JT, Krisciunas GP, Grillone GA, Gonzalez RM, Winter MR, Griever SC, Fernandes E, Medzon R, Blansfield JS, Blumenthal A. Emergency Airway Response Team Simulation Training: A Nursing Perspective. Dimens Crit Care Nurs. 2017 Sep/Oct; 36(5):290-297. PMID: 28777116.
- Published on 7/28/2017
Grillone GA, Wang Z, Krisciunas GP, Tsai AC, Kannabiran VR, Pistey RW, Zhao Q, Rodriguez-Diaz E, A'Amar OM, Bigio IJ. The color of cancer: Margin guidance for oral cancer resection using elastic scattering spectroscopy. Laryngoscope. 2017 Sep; 127 Suppl 4:S1-S9. PMID: 28752518.
- Published on 7/1/2017
Russell KA, Brook CD, Platt MP, Grillone GA, Aliphas A, Noordzij JP. The Benefits and Limitations of Targeted Training in Flexible Transnasal Laryngoscopy Diagnosis. JAMA Otolaryngol Head Neck Surg. 2017 Jul 01; 143(7):707-711. PMID: 28472351.
- Published on 5/1/2017
Jamal BT, Grillone GA, Jalisi S. Chemoresponse Assay in Head and Neck Cancer Patients: A Three-Year Follow Up. J Clin Diagn Res. 2017 May; 11(5):XC01-XC03. PMID: 28658890.
- Published on 12/9/2015
Tsai AC, Krisciunas GP, Brook C, Basa K, Gonzalez M, Crimlisk J, Silva J, Grillone GA. Comprehensive Emergency Airway Response Team (EART) Training and Education: Impact on Team Effectiveness, Personnel Confidence, and Protocol Knowledge. Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):457-63. PMID: 26658070.
- Published on 11/14/2015
Shah BA, Qureshi MM, Jalisi S, Grillone G, Salama A, Cooley T, Zaner K, Sakai O, Truong MT. Analysis of decision making at a multidisciplinary head and neck tumor board incorporating evidence-based National Cancer Comprehensive Network (NCCN) guidelines. Pract Radiat Oncol. 2016 Jul-Aug; 6(4):248-54. PMID: 26777060.
- Published on 10/8/2015
Krisciunas GP, Platt M, Trojanowska M, Grillone GA, Haines PC, Langmore SE. A Novel In Vivo Protocol for Molecular Study of Radiation-Induced Fibrosis in Head and Neck Cancer Patients. Ann Otol Rhinol Laryngol. 2016 Mar; 125(3):228-34. PMID: 26453487.
- Published on 8/17/2015
Wong S, Brook C, Grillone G. Management of Wire Brush Bristle Ingestion: Review of Literature and Presentation of an Algorithm. Ann Otol Rhinol Laryngol. 2016 Feb; 125(2):160-4. PMID: 26282588.
- Published on 3/18/2015
Brook CD, Platt MP, Russell K, Grillone GA, Aliphas A, Noordzij JP. Time to competency, reliability of flexible transnasal laryngoscopy by training level: a pilot study. Otolaryngol Head Neck Surg. 2015 May; 152(5):843-50. PMID: 25788339.
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