Catherine Moore and Mariel Seiglie Receive Graduate Student Travel Awards from ASPET for the 2016 Experimental Biology Meeting

March 4th, 2016 in Recent News

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Catherine “Cassie” Moore and Mariel Seiglie, both Ph.D. graduate students in the Graduate Program for Neuroscience/Program in Biomolecular Pharmacology, have been selected to receive Graduate Student Travel Awards from the American Society of Pharmacology & Experimental Therapeutics (ASPET). In addition to covering registration fees for the Experimental Biology 2016 meeting, Cassie and Mariel will each receive $1,000 to cover their travel expenses to San Diego. The awards will be presented at the EB 2016 meeting. This important annual meeting hosts over 14,000 scientists and exhibitors representing six sponsoring societies and several guest societies. As this meeting is an important showcase for Ph.D. graduate students’ research, the ASPET Travel Award is highly prized.

Both Cassie and Mariel conduct their graduate research in the Laboratory of Addictive Disorders (LAD). Cassie, who is mentored by LAD Co-Director, Pietro Cottone, Ph.D., is investigating how overeating sugar-rich foods may affect mesolimbic dopaminergic reward. Her poster will show how a history of overconsumption of palatable food alters sensitivity to the rewarding and stimulatory effects of amphetamine-like drugs in a phase dependent manner (i.e. during palatable food access and withdrawal).

Mariel is mentored by LAD Co-Director Valentina Sabino, Ph.D. Her graduate research focuses on neuropeptide systems, specifically PACAP-PAC1R, which are involved in medicating the stress response towards acute chronic stressors. Her poster will demonstrate how intra-CeA and intra-BNST PACAP microinfusions can effect stress-like behavior and how the PACAP receptor, PAC1R, is responsible for mediating these effects.

Drs. Cottone and Sabino are internationally renowned for their research on addictive behaviors. The research conducted in the LAD provides important new insights in addictive behavior, especially in overeating and drug addiction. Their work holds great promise in developing novel therapeutics for the treatment of addictive behaviors. Please visit the Laboratory of Addictive Disorders website for more information.

Congratulations, Cassie and Mariel!

Rebecca Benham Vautour Selected for ASPET Washington Fellows Program

March 4th, 2016 in Alumni Spotlight

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Congratulations to Rebecca Benham Vautour, Ph.D., on being selected for the ASPET Washington Fellows Program [HPA]. Dr. Benham Vautour, a post-doctoral fellow in the Laboratory of Genetic Neuropharmacology at McLean Hospital, is one of 10 selected from across the U.S. to participate in this program. She graduated from with a Ph.D. in Pharmacology and Neuroscience from the Program in Biomolecular Pharmacology at Boston University School of Medicine in 2012. As a graduate student in the Laboratory of Translational Epilepsy under the mentorship of Dr. Shelley J. Russek, Dr. Benham Vautour’s graduate research thesis was on bdnfAND jak/stat: Partners in Seizure-Induced GABA-A Receptor Down Regulation.” Her research at McLean’s focuses on the role of GABA-A in depression.

Profile on Dr. Neil Ganem’s Research: “Every Cell Has a Story”

January 14th, 2016 in Recent News

Told in stunning cell images and videos, “Every Cell Has a Story” chronicles the career development of Neil J. Ganem, Ph.D., Assistant Professor in the Departments of Pharmacology & Experimental Therapeutics and Medicine, Section of Hematology and Medical Oncology, at Boston University School of Medicine. The article follows Neil’s rise from Dartmouth as young graduate student scientist making a momentous, life-changing decision on his research focus to a rising junior cancer biology/pharmacology investigator and director of the Laboratory of Cancer Cell Biology in the Cancer Center at BUSM.

Please visit Dr. Ganem’s Laboratory of Cancer Cell Biology website for more information on his research.

Laboratory of Addiction Genetics Makes Important Discovery in Methamphetamine Addiction

December 11th, 2015 in Recent News

EurekAlert.org reported that researchers in the Laboratory of Addiction Genetics in the Department of Pharmacology & Experimental Therapeutics and Psychiatry at Boston University School of Medicine have identified a gene that may be linked to methamphetamine addiction. The article, “Hnrnph1 is a Quantative Trait Gene for Methamphetamine Sensitivity”Hnrnph1 is a Quantative Trait Gene for Methamphetamine Sensitivity” in PLOS Genetics. The article’s first author, Neema Yazdani, a Program in Biomolecular Pharmacology Ph.D. graduate student, is currently conducting his doctoral research work in the Laboratory of Addiction Genetics under the mentorship of Laboratory Director and Principal Investigator, Camron D. Bryant, Ph.D., who is the senior and corresponding author on the paper. Dr. Bryant’s research focuses on the genetic basis of behaviorial and molecular traits in substance abuse with the goal of discovering novel psychotherapeutics to treat addictive disorders. For more on this research, please visit the Laboratory of Addiction Genetics website.

Neema Yazdani Selected for Platform Presentation at GSI Symposium on Tuesday, November 10, 2015

November 9th, 2015 in Student Spotlight

Neema Yazdani, a Program in Biomolecular Pharmacology Ph.D. graduate student, has be selected to present a platform presentation at the Tuesday, November 10, 2015 Genome Science Institute’s (GSI) Annual Research Symposium. Neema’s presentation is entitled, ‘HnRNP H1 regulates the stimulant and addictive properties of methamphetamine: Transcriptomic and spliceomic analyses uncover novel neurodevelopmental mechanisms” and is based upon the research he is carrying out in the Laboratory of Addiction Genetics in the Department of Pharmacology & Experimental Therapeutics under the mentorship of Dr. Camron Bryant.

The GSI symposium will be held in Hiebert Lounge, L-14th Floor in the School of Medicine from 12:00 to 5:00 p.m. and will include both poster sessions from 12:30 to 2:30 p.m. and platform presentations from 2:30 to 4:30 p.m. The awards ceremony will immediate follow the platform presentations.

Dr. David Farb’s research is highlighted in “Neurophysiology Charges Ahead,” Science 2015

October 9th, 2015 in Recent News

In his recent article, “Neurophysiology Charges Ahead,” Alan Dove reviews recent advances in electrophysiology and genetic approaches to neuroscience. The research of Dr. David Farb, Director and Principal Investigator of the Laboratory of Molecular Neurobiology in the Department of Pharmacology & Experimental Therapeutics at Boston University, among others, is highlighted. Noting the evolution of electrophysiology techniques, Dr. Farb discusses how these recent advances have increased the ability to measure brain activity which may lead to therapeutic discoveries for the treatment of neurodegenerative diseases such as Alzheimer’s disease. For more information on Dr. Farb’s research, please visit his website.

The Pharmacologist September 2015 Issue is Now Available

September 17th, 2015 in Recent News

 September 2015 – Volume 57, Issue 3

In This Issue:

  • Message from the President: Dr Kenneth E. Thummel
  • EB2016 Meeting Highlights
  • Feature Article: Sleepy Sickness, Oliver Sacks, and the Early Days of L-Dopa
  • Science Policy News
  • Education News
  • Journal News
  • Membership News
  • Members in the News
  • Division News
  • Chapter News
  • Meetings and Congresses

Joon Ying Boon and Megan Varnum Participate in the 25th Annual BUMC Art Days and GMS Student Art Exhibit

April 21st, 2015 in Recent News

Joon Ying Boon and Megan Varnum, Program in Biomolecular Pharmacology Ph.D. graduate students, contributed to the success of 25th Annual BUMC Art Days, March 30-31, 2015. BUMC students, faculty and staff were invited to contribute paintings, photos, poetry, sculpture, needlework, etc. for the event. This year’s keyword was INTERSECT and a special display section was set aside in Hiebert Lounge devoted to works focused on “Intersect.” On Tuesday, April 14, 2015, Joon’s and Megan’s art works were also displayed at a special exhibit sponsored by the Division of Graduate Medical Sciences featuring paintings and photographs by DGMS graduate students.

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Joon Ying Boon has entitled her piece, “Grandfather Trees.” She explains that “somewhere in the overcrowded, busy and skyscrapers-filled urban Hong Kong, there is an old park with old trees where one can find peace and serenity.”

 

 

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Joon is also a senior Ph.D. student pursing her dissertation research on the identification of proteins that bind to and regulate LRRK2 in the Laboratory of Neurodegeneration, under the mentorship of Principal Investigator and Professor of Pharmacology and Neurology, Benjamin Wolozin, M.D., Ph.D.

 

The banner painting above was done by Megan Varnum’s and is entitled, “A Mexican Hillside”. Megan elaborated on that, “Mexicans incorporate vibrant color into nearly every aspect of their culture, and I wanted to reflect that in this painting. Although I cannot personally take credit for taking the photo from which this was painted, it reminds me of the times my family would go to Mexico and how inspired I would be by all the colors.”

Varnum 2011-7-18 Image

Megan is a senior Ph.D. student doing her dissertation research on traumatic brain injury (TBI) in the Laboratory of Molecular NeuroTherapeutics under the direction of mentor, Principal Investigator, and Professor of Pharmacology and Neurology, Tsuneya Ikezu, M.D., Ph.D.

 

These two aspiring young scientists inspire us with their creativity.  Beautiful work, Joon and Megan!

Sanghee Lim received 2015 Medical Student Research Grant from the Melanoma Research Foundation

April 13th, 2015 in Student Spotlight

Congratulations to Sanghee Lim on being awarded a 2015 Medical Student Research Grant from the Melanoma Research Foundation for his proposal, “Defining Novel Mechanisms of Genome Instability in Melanoma.” The Medical Student Research Grant is awarded for a one-year period in order “to provide opportunities and funding for medical students to engage in short clinical or laboratory-based research projects focused on better understanding the biology and treatment of melanoma.” Sanghee is one of six medical students who received the nationally competitive award this year.

An MD/PhD student Program in Biomolecular Pharmacology, Sanghee is working under the guidance of Dr. Neil Ganem, Assistant Professor of Pharmacology & Experimental Therapeutics and Medicine, in the Laboratory of Cancer Cell Biology at the Shamim and Ashraf Dahod Breast Cancer Research Laboratories. His work is aimed at defining the mechanisms that give rise to chromosome instability in human melanoma. In particular, Sanghee is testing whether activating mutations in the oncogene BRAF, which occur in ~80% of all melanomas, directly promote mitotic defects.

Great job, Sanghee! Keep up the great work.

Neema Yazdani Receives IBANGS 2015 Outstanding Graduate Student Travel Award

March 11th, 2015 in Student Spotlight

Neema Yazdani is one of two graduate students selected for the 2015 “Outstanding Graduate Student Travel Award” for the 17th Annual International Behavioral and Neural Genetics Society (IBANGS) Meeting in Uppsala, Sweden. Neema is a third year PhD candidate and Program in Biomolecular Pharmacology student in the Laboratory of Addiction Genetics under the mentorship of Camron D. Bryant, Ph.D., Assistant Professor of Pharmacology and Psychiatry. As a recipient of this award, Neema is invited to present his research as an oral presentation titled, “Hnrnph1 is a quantitative trait gene for methamphetamine sensitivity”. Neema’s efforts in generating and phenotyping TALENs-targeted Hnrnph1 knockout mice combined with striatal transcriptome analysis via RNA-seq led to the identification of Hnrnph1 as a novel quantitative trait gene involved in the stimulant response to methamphetamine. His transcriptome results suggest that Hnrnph1 could regulate the neural development of the mesocorticolimbic circuitry which would have widespread implications for understanding the etiology of a variety of neurobiological disorders involving a dysregulation of dopamine transmission.