Pulmonary CCR Conference

The Pulmonary Center does research to improve medicine, which is facilitated by ensuring that scientists and clinicians are in regular and open contact. The Pulmonary Combined Clinical and Research (CCR) Conference is a manifestation of that. The CCR Conference unifies two efforts which were previously distinct. In Pulmonary Grand Rounds, physicians present cases and discuss cutting-edge clinical approaches to medical challenges. In Work-in-Progress Seminars, scientists present research questions, experiments, results, and interpretations, discussing implications for advancing biology and medicine. The Pulmonary CCR Conference includes both of these activities in one extended session. As often as possible, the 2 components are coordinated so that the medical cases and the research questions are directly and immediately mutually informative. All Pulmonary Center members (faculty, trainees, and staff, from all disciplines) participate in both components. Pulmonary medicine and research benefit when scientists, clinicians, and clinician-scientists all learn from and inform each other meaningfully and productively.

The Pulmonary CCR conference occurs weekly on Wednesdays from 3:30pm-5:30pm.

Pulmonary CCR Conference Fall/Winter 2019 Schedule:

Date / Location	Scientific Seminar	Clinical Cases
9/4 X714-715	Katrina Traber “Neutrophil Remodeling During Pneumonia”	Justin Lui, Lakshmana Swamy
9/11 X714-715	Renda Wiener “Challenges & future directions in implementing lung cancer screening”	Samuel Belok Wei He
9/18 X714-715	Jay Mizgerd “Pneumonia and the lung-resident immune system”	Nicholas Bosch Stephanie Hon
9/25 X714-715	Darrell Kotton “Stem cell/disease modeling”	Nicholas Bosch Andrew Berical
10/2 X714-715	Paul Maglione “CVID”	Jessica Gereige Kari Gillmeyer
10/9 Bakst Aud.	George O’Connor “COPD/GWAS Lung function”	Raj Parikh Kate Steinberg
10/16 X714-715	Joe Kaserman “Modeling AATD Hepatocyte Injury Using Patient Specific Syngenetic iHeps”	Shelsey Johnson Erin Crossey
10/23 X714-715	Lakshmana Swamy “Burnout in Intensive Care Physicians & Nurses” Andy Tilston-Lunel “Aberrant Epithelial Polarity Promotes the Development of Precancerous Airway Lesions”	Nathan Mesfin Ariella Krones
10/30 Evans Seminar Room	(Pulmonary Faculty Meeting)	Shelsey Johnson Caitlin Butler
11/6 Evans Seminar Room	Feedback Session	Theodore Lee Nathan Mesfin
11/13 Evans Seminar Room	Emad Arafa “A Resilient Alveolar Macrophage Phenotype”” Justin Lui “Proof-of-Concept Rocaglate-eluting PGA Meshes for Locoregional Lung Cancer Therapy”	Mallory LeSieur Caitlin Butler
11/20 Evans Seminar Room	Matt Jones “Airway Ciliated Cell Heterogeneity During Lung Infection”	Ariella Krones Erin Crossey
11/27	No Conference
12/4 Evans Seminar Room	Kristine Abo “Pluripotent Stem Cell-Based Modeling of Cigarette Smoke Injury” Andrew Berical “IPS Cells as a Novel Model for Cystic Fibrosis”	Nathan Mesfin Mallory LeSieur
12/11 Evans Seminar Room	Kimberly Barker “Resident Memory B cells are an Important Component of Lung Adaptive Immunity” Samuel Belok “Brief EVALI Documentation Update”	Shelsey Johnson Ariella Krones
12/18 Evans Seminar Room	Filiz Korkmaz “Location Matters: Distinct Roles for LOX-1 in the Lung” Samuel Belok “Brief EVALI Documentation Update”	Caitlin Butler Erin Crossey
12/25	No Conference
1/1	No Conference
1/8 Evans Seminar Room	Stephanie Hon Julia Hicks-Berthet	Mallory LeSieur Nathan Mesfin
1/15 Evans Seminar Room	Claire Burgess Kari Gillmeyer	Shelsey Johnson Caitlin Butler
1/22 L-110	Jerry Brody Lecture: Scott Budinger “Understanding Aging through the Prism of Alveolar Macrophages”	Mallory LeSieur
1/29 Evans Seminar Room	Nicholas Bosch Leon Yuliang Sun	Ariella Krones Erin Crossey
2/5 Evans Seminar Room	Barbara Ludeke Rhiannon Werder	Nathan Mesfin Caitlin Butler
2/12 Evans Seminar Room	Eric Abston Arjun Sharma	Erin Crossey Mallory Lesieur
2/19 Evans Seminar Room	Carolina Lyon De Ana Bibek Thapa	Ariella Krones Caitlin Butler
2/26 Evans Seminar Room	Anna Engler Eric Brownhill	Theodore Lee Erin Crossey
3/4 Evans Seminar Room	Carla Kim, PhD Harvard Medical School	Shelsey Johnson
3/11 Evans Seminar Room	Kate Steinberg Raj Parikh	Ariella Krones Caitlin Butler
3/18 Evans Seminar Room	Tachira Pichardo Samuel Belok	Shelsey Johnson Nathan Mesfin
3/25 Evans Seminar Room	Bob Dickson, MD University of Michigan	Nathan Mesfin
4/1 X714-715	Gordon Snider Lecture: Naftali Kaminski, MD Yale School of Medicine	Mallory LeSieur
4/8 Evans Seminar Room	Alicia Soucy Justin Rucci	Shelsey Johnson Erin Crossey
4/15 Evans Seminar Room	Michael Breen Mike Garcia	Mallory LeSieur Caitlin Butler
4/22 Evans Seminar Room	Eddie Nunez Anukul Shenoy	Shelsey Johnson Nathan Mesfin
4/29 Evans Seminar Room	Jin Yuan Christine Odom	Nathan Mesfin Caitlin Butler
5/6 Evans Seminar Room	Robert Smyth Michael Herriges	Shelsey Johnson Erin Crossey
5/13 Evans Seminar Room	Sheng Si Beth Becker	Theodore Lee Caitlin Butler
5/20	No Conference
5/27 Evans Seminar Room	Kiloni Quiles-Franco Jessica Gereige	Caitlin Butler Erin Crossey
6/3 Evans Seminar Room	Giovanni Ligresti	Shelsey Johnson Ariella Krones
6/10 Evans Seminar Room	Elim Na Taylor Matte	Mallory LeSieur Nathan Mesfin
6/17 Evans Seminar Room	Heedoo Lee Senegal Carty	Ariella Krones Mallory LeSieur
6/24 Evans Seminar Room	Jake Le Seur Alex Ysasi	Shelsey Johnson Erin Crossey
7/1 Evans Seminar Room	Ke Xu Kostas Alysandratos	Mallory LeSieur Ariella Krones
7/8 Evans Seminar Room	Rachel Zemans, MD University of Michigan	Nathan Mesfin Mallory LeSieur
7/15 Evans Seminar Room	Jessie Huang Adeline Matschulat	Caitlin Butler Ariella Krones
TBD Evans Seminar Room	Kenrie Hui, PhD University of Hong Kong	TBD
TBD Evans Seminar Room	Marry Williams Lecture: Tushar Desai, MD Stanford University	TBD

Work in Progress Spring/Summer 2019 Schedule:

Date	Speaker	Presentation Title
1/4	Michael Herriges/Yuri Kim	“Transplantation of primary and PSC-derived lung epithelial progenitor cells”
1/11	Renda Wiener	“Untangling overuse: PDE-5-inhibitors for Groups 2/3 Pulmonary Hypertension”
1/18	Sarah Mazzilli	“Molecular Characterization of a Pre-Clinical Model for Lung Cancer Interception”
1/25	Kim Barker/Andrew Berical	“Pneumococcal exposures elicit resident memory B cells poised to secrete class-switched antibodies in the lung” “Induced Pluripotent Stem Cells and Personalized Cystic Fibrosis Drug Prediction”
2/1	Hannah Wunsch, University of Toronto	“ICU staffing models: do they make a difference?”
2/8	Judy Campisi- Jerome Brody Lecture	“Cellular Senescence, the Lung and Aging: The Jerry Brody Connection”
2/15	Kristine Abo/Sean Corbett	“Pluripotent Stem Cell-Based Modeling of Cigarette Smoke Injury” “Identifying Lung-Cell-Type-Associated Responses to Compound Perturbation”
2/22	Emad Arafa/Nathan Kingston	“Alveolar Macrophages Dynamics During Pneumococcal Pneumonia” “Roles for Hippo Pathway Effectors Taz and Yap in Fibroblast Populations During Pulmonary Fibrosis”
3/1	Anukul Shenoy/ Filiz Korkmaz	“Lung-Resident CD4+ Memory T Cell and Epithelial Crosstalk During Heterotypic Immunity”
3/8	Roberto Machado, Indiana University School of Medicine	“NAMPT and pulmonary vascular remodeling in PAH”
3/15	Jussi Saukkonen	“Phenobarbital in the treatment of acute alcohol withdrawal syndrome”
3/22	Claire Burgess/Julia Hicks-Berthet	“Generation of human alveolar epithelial type 1 cells from pluripotent stem cells” “Yap and Taz-regulated control of goblet cell fate in the airway epithelium”
3/29	Barbara Ludeke/Michael Breen	“Towards a linked RNA synthesis and RNA capping assay for RSV” “Characterizing the lung B memory cell population after respiratory viral infection”
4/5	Bela Suki	“Bioengineering approaches toward understanding honeycombing in pulmonary fibrosis and tissue deterioration in emphysema”
4/12	Kari Gillmeyer/Yuliang (Leon) Sun	“Delivery of care for patients with pulmonary hypertension” “Establishing an iPSC-derived AEC2s model to study childhood interstitial lung disease”
4/19	Alicia Wooten/Stephanie Hon	“Phosphodiesterase 2 deletion in Streptococcus pneumoniae D39 elicits a robust type I interferon response in macrophages” “Single Cell Sequencing and Lineage Tracing of the Origins of Pulmonary Vasculature”
4/26	Nick Bosch/Rhiannon Werder	“Derivation and Validation of a Novel Measure of Septic Shock Severity” “Understanding the Function of COPD Susceptibility Genes using CRISPRi-Targeted Human Induced Pluripotent Stem Cell (iPSC)-Derived Lung Epithelium”
5/3	James Murphy, M.D.	“Critical Care Quality Improvement at BMC”
5/10	Eric Abston/ Ming-Ming Lee	“Noninvasive Quantification of Fibrotic Lung Disease: of Mice and Men” “Predicting future pneumonia from baseline clinical risk factors and blood protein markers”
5/17	No Seminar- ATS	TBD
5/24	No Seminar- ATS	TBD
5/31	*Avi Spira- Mary Williams Lecture*	“The Road Rarely Traveled: a 20-year Journey Towards Early Lung Cancer Detection.”
6/7	*Timothy Blackwell, Vanderbilt University Medical Center – Gordon Snider Memorial Lecture*	“Progress in Understanding Genetic Mechanisms of Pulmonary Fibrosis.”
6/14	*Tien Peng- UCSF*	“Traversing the Wall: Signaling Across the Basement Membrane in Lung Regeneration.”
6/21	Elim Na/Carolina Lyon De Ana	“Determining epithelial-specific roles for the lung-protective cytokine LIF during pneumonia.” “The T-lymphocytic landscape of heterotypic immune lungs.”
6/28	Kostas Alysandratos	“Pluripotent stem cells to unravel the role of alveolar type 2 epithelial cells in the pathogenesis of pulmonary fibrosis.”
7/5	No Seminar
7/12	Christine Odom/Adeline Matsculat	“Liver-dependent lung defense during sepsis.” “Defining molecular signals that influence airway basal cell renewal and growth.”
7/19	Barbara Ludeke	“Towards a High Throughput Screening Assay for Multiple Activities of RSV RNA Polymerase.”
7/26	Alan Fine	“Lung Lymphatic Remodeling”