Philipp Mews, Ph.D.
Assistant Professor of Pharmacology, Physiology & Biophysics
The Mews Lab is pioneering research at the intersection of neuroepigenetics, metabolism, and neural plasticity in the adult brain, with an emphasis on substance use disorders. Our research builds on the concept that metabolic processes and the epigenome are deeply interconnected, influencing gene expression and behavior in profound ways. At the heart of our work are two critical questions that drive our investigations:
Interplay of Metabolism and Epigenetics: How do metabolic processes intertwine with epigenetic factors to orchestrate gene responses in the brain? This question delves into the heart of cellular function, exploring the dynamic and reciprocal relationship between the metabolic state of a cell and its epigenetic landscape. We are committed to deciphering how these interactions dictate gene expression patterns, influence neural plasticity, and ultimately shape cognitive and behavioral outcomes.
Influence of Diet and Substance Use on Chromatin Dynamics: How do external factors like nutrients and drugs of abuse alter chromatin states, thereby impacting brain function? Here, we probe the profound effects of environmental inputs on the brain’s epigenetic makeup. We seek to understand how these factors induce changes in chromatin structure and function, leading to lasting modifications in neural circuits and behavior. This line of investigation is particularly crucial in understanding the pathogenesis of substance use disorders and in identifying potential epigenetic targets for therapeutic intervention.
The lab combines innovative molecular and behavioral methodologies to explore how metabolism-to-epigenome signaling governs brain function. Our work not only bridges diverse scientific disciplines but also holds the promise of unlocking new therapeutic avenues for neuropsychiatric disorders. Join our team and explore opportunities to contribute, learn, and thrive in our dynamic research environment.