Guillaume Andrieu PhD and Jordan Shafran report research on new mechanisms to develop immunotherapy for triple negative breast cancer

The research team of Andrieu and Shafran, directed by Gerald Denis PhD, in the BU-BMC Cancer Center, has just reported that “BET bromodomain targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response”, which appeared today in Cell Reports ‘Sneak Peek’ https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3260754

The mechanisms that control the expression of immune inhibitory molecules in diverse cancer types, such as PD-L1, and host immune receptors such as PD-1 on T cells in the tumor microenvironment, are being investigated urgently. New tools to inhibit these checkpoints show great promise to unleash anti-tumor immunity, and results of recent cancer clinical trials are encouraging. Immunotherapy as an exciting and evolving field was recognized on October 1, 2018, with the award of the Nobel Prize in Medicine to Honjo and Allison. On the other hand, clinical cases in which immune therapy approaches fail are poorly understood, and failure is common enough for certain cancer types to have caused widespread frustration in clinical trials. Given the limited therapeutic options available to patients with triple negative breast cancer, new modalities are urgently needed, and promising results from new immunotherapy clinical trials could quickly reshape the treatment of this subtype of breast cancer.

Here, Andrieu, Shafran and Denis show that inhibition of the BET bromodomain protein family can reduce PD-L1 expression in cellular models of triple negative breast cancer. It is also highly innovative and significant that they show these same pathways control PD-1 expression in human primary T cells, which holds out the possibility that multiple relevant cells in the tumor microenvironment could be targeted by these approaches. They are continuing this research, with support from the National Cancer Institute with a new grant, called “BET bromodomain proteins and the immunometabolism of triple negative breast cancer” (R01 CA222170).

Lead APP Announcement

We are pleased to announce that Margaux Dockerty, RN, MSN, AGNP and Arielle Davidson, MSN, RN, CCRN have accepted new positions in the section of hematology and medical oncology. Margaux will serve as Lead APP for Hematology/Hematologic Malignancies, and Arielle will serve as Lead APP for Solid Tumor Oncology.

Both Margaux and Arielle have already contributed immensely to the section, and bring to these new roles a breadth of experience in their respective areas. Margaux received a BSN and a Masters Degree in Nursing and Adult Gerontology from Boston College, and joined our section in 2022. She has played a key role in supporting the stem cell transplant service and developing a growing program in CAR-T therapy; she has also contributed time and effort to develop and train new APPs in the bone marrow biopsy clinic and has supported the gene therapy program in sickle cell disease.

Arielle Davidson received a BA from UCLA, and Masters in Clinical Nurse Leadership from the University of Maryland; she has experience working as a critical care nurse and as a nurse practitioner in neurocritical care before joining our section in 2022 in the Head and Neck and Thoracic Oncology groups. In addition to her outstanding clinical work, she has played an important role mentoring a number of our new APPs.

As Lead APPs,  Margaux and Arielle will help oversee and support section APPs in their respective areas; they will also provide guidance to administrative and operations leadership as we continue to expand our cancer programs. We are excited to have them in these new roles!