BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition
Published April 2018 Provided by: American Association for Cancer Research Publications | Source: Molecular Cancer Research Guillaume P. Andrieu and Gerald V. Denis DOI: 10.1158/1541-7786.MCR-17-0568 Abstract Transcriptional programs in embryogenesis and cancer, such as the epithelial-to-mesenchymal transition (EMT), ensure cellular plasticity, an essential feature of carcinoma progression. As effectors of signal transduction, the bromodomain and extraterminal […]
Finding Lung Cancer in the Nose
Tuesday, February 28, 2017 Written by: Barbara Moran | Source: BUToday Lung cancer is the deadliest form of cancer in the United States—and in the world. According to the National Cancer Institute, it accounts for more than a quarter of cancer deaths in this country, killing about 158,000 people in 2016. Because lung cancer is so lethal, many […]
Researchers Tease Apart a Pathway Certain Cancer Cells Use to Replicate
Thursday, January 28th, 2016 | Source: BUSM A new “player” in the way certain aggressive cancer cells may reproduce has been identified. It is hoped that these findings may lead to the identification of new cancer targets and may ultimately lead to new therapeutics. The telomere is a repetitive DNA sequence that caps the ends […]
Epigenetic Regulation of Metastatic Breast Cancer Progression Could Guide Prognosis and Future Therapies
Friday, January 8th, 2016 | Source: BUSM A gene that plays a role in the development of breast cancer to metastatic disease has been identified which may help to predict disease progression and serve as a target for the development of future breast cancer therapies. These findings by Boston University School of Medicine (BUSM) researchers […]