In the U.S., studies show that African Americans are more likely to get pancreatic cancer (PC) than Caucasians. Poor oral health, specifically adult tooth loss and periodontal disease prevalence, has a similar pattern. Using data from the Black Women’s Health Study, researchers from the Slone Epidemiology Center at BU found that compared to African American women who showed no signs of poor oral health, those who reported adult tooth loss had a substantially increased risk of PC. This association become even stronger for those who had lost at least five teeth.
According to the researchers, these observations may be related to oral bacteria and the inflammation caused by certain bacteria. In previous studies among different populations the presence of circulating antibodies to selected oral periodontal pathogens was associated with increased risk of PC.
“Oral health is a modifiable factor. Apart from avoiding cigarette smoking, there is little an individual can do to reduce risk of PC. Improving access to low cost, high quality dental care for all Americans may decrease racial disparities in this cancer,” said Julie Palmer, ScD, associate director of BU’s Slone Epidemiology Center and a professor of epidemiology at BUSPH.
These findings appear online in the journal Cancer Epidemiology, Biomarkers & Prevention.
This work was supported in part by the National Institutes of Health grants NCI U01CA187508 (J.R. Palmer, H. Gerlovin, D.S. Michaud), NCI R01CA098663 (J.R. Palmer, Y.C. Cozier) and NCI U01CA164974 (J.R. Palmer, H. Gerlovin, Y.C. Cozier).