Pulmonary CCR Conference

The Pulmonary Center does research to improve medicine, which is facilitated by ensuring that scientists and clinicians are in regular and open contact. The Pulmonary Combined Clinical and Research (CCR) Conference is a manifestation of that. The CCR Conference unifies two efforts which were previously distinct. In Pulmonary Grand Rounds, physicians present cases and discuss cutting-edge clinical approaches to medical challenges. In Work-in-Progress Seminars, scientists present research questions, experiments, results, and interpretations, discussing implications for advancing biology and medicine. The Pulmonary CCR Conference includes both of these activities in one extended session. As often as possible, the 2 components are coordinated so that the medical cases and the research questions are directly and immediately mutually informative. All Pulmonary Center members (faculty, trainees, and staff, from all disciplines) participate in both components. Pulmonary medicine and research benefit when scientists, clinicians, and clinician-scientists all learn from and inform each other meaningfully and productively.

 

The Pulmonary CCR conference occurs weekly on Wednesdays from 3:30pm-5:30pm.

Pulmonary CCR Conference Fall/Winter 2019 Schedule:

 

 

 

Date / Location Scientific Seminar Clinical Cases
9/4
X714-715
Katrina Traber
“Neutrophil Remodeling During Pneumonia”
Justin Lui,
Lakshmana Swamy
9/11
X714-715
Renda Wiener
“Challenges & future directions in implementing lung cancer screening”
Samuel Belok
Wei He
9/18
X714-715
Jay Mizgerd
“Pneumonia and the lung-resident immune system”
Nicholas Bosch
Stephanie Hon
9/25
X714-715
Darrell Kotton
“Stem cell/disease modeling”
Nicholas Bosch
Andrew Berical
10/2
X714-715
Paul Maglione
“CVID”
Jessica Gereige
Kari Gillmeyer
10/9
Bakst Aud.
George O’Connor
“COPD/GWAS Lung function”
Raj Parikh
Kate Steinberg
10/16
X714-715
Joe Kaserman
“Modeling AATD Hepatocyte Injury Using Patient Specific Syngenetic iHeps”
Shelsey Johnson
Erin Crossey
10/23
X714-715
Lakshmana Swamy
“Burnout in Intensive Care Physicians & Nurses”
Andy Tilston-Lunel
“Aberrant Epithelial Polarity Promotes the Development of Precancerous Airway Lesions”
Nathan Mesfin
Ariella Krones
10/30
Evans Seminar Room
(Pulmonary Faculty Meeting) Shelsey Johnson
Caitlin Butler
11/6
Evans Seminar Room
Feedback Session Theodore Lee
Nathan Mesfin
11/13
Evans Seminar Room
Emad Arafa
“A Resilient Alveolar Macrophage Phenotype””
Justin Lui

Proof-of-Concept Rocaglate-eluting PGA Meshes for Locoregional Lung Cancer Therapy”
Mallory LeSieur
Caitlin Butler
11/20
Evans Seminar Room
Matt Jones
“Airway Ciliated Cell Heterogeneity During Lung Infection”
Ariella Krones
Erin Crossey
11/27 No Conference
12/4
Evans Seminar Room
Kristine Abo
“Pluripotent Stem Cell-Based Modeling of Cigarette Smoke Injury”
Andrew Berical
“IPS Cells as a Novel Model for Cystic Fibrosis”
Nathan Mesfin
Mallory LeSieur
12/11
Evans Seminar Room
Kimberly Barker
“Resident Memory B cells are an Important Component of Lung Adaptive Immunity”
Samuel Belok
“Brief EVALI Documentation Update”
Shelsey Johnson
Ariella Krones
12/18
Evans Seminar Room
Filiz Korkmaz
“Location Matters: Distinct Roles for LOX-1 in the Lung”
Samuel Belok
“Brief EVALI Documentation Update”
Caitlin Butler
Erin Crossey
12/25 No Conference
1/1 No Conference
1/8
Evans Seminar Room
Stephanie Hon
“Tobacco Treatment for Hospitalization smokers”
Julia Hicks-Berthet
“Control of Airway Cell Fate via the Hippo Pathway Effectors Yap and Taz”
Mallory LeSieur Nathan Mesfin
1/15
Evans Seminar Room
Claire Burgess
“Generation of Human Alveolar Epithelial Type 1 Cells from Pluripotent Stem Cells”
Kari Gillmeyer
“Improving Care Delivery for Patients with Pulmonary Hypertension”
Shelsey Johnson Caitlin Butler
1/22
L-110
Jerry Brody Lecture: Scott Budinger
“Understanding Aging through the Prism of Alveolar Macrophages”
Mallory LeSieur
1/29
Evans Seminar Room
Nicholas Bosch
“Guidline Concordant Insulin Infusion Initiation During Critical Illness”
Leon Yuliang Sun
“Characterizing the Cellular Heterogeneity of Human PSC-Derived AEC2s”
Ariella Krones Erin Crossey
2/5
Evans Seminar Room
Rhiannon Werder
“A CRISPR Interference Approach to Investigate the Role of FAM13A in induced Pluripotent Stem Cell-derived Lung Epithelial Cells”
Nathan Mesfin Caitlin Butler
2/12
Evans Seminar Room
Eric Abston
Carolina Lyon De Ana
Erin Crossey Mallory Lesieur
2/19
Evans Seminar Room
Anna Engler
Arjun Sharma
Ariella Krones Caitlin Butler
2/26
Evans Seminar Room
Bibek Thapa
Eric Brownhill
Theodore Lee Erin Crossey
3/4
Evans Seminar Room
Carla Kim, PhD
Harvard Medical School
Shelsey Johnson
3/11
Zoom
Raj Parikh
Michael Ieong, BMC Pulmonary Section Response to COVID-19
Ariella Krones Caitlin Butler
3/18
Zoom
Michael Ieong & James Murphy, COVID-19 Response Update
Darrell Kotton & Felicia Chen, Scheduling Update
Allan Walkey, Steroid Data Review in COVID/ARDS
3/25
Zoom
Nick Bosch,  Toolkit for Non-ICU Providers
Michael Ieong, Inpatient Operations
Fred Little, Ambulatory Operations
Ehab Billatos, Procedures
Katrina Traber, Best Practices Document/ Volunteer Opportunities
Erin Crossey 
Shelsey Johnson
4/1
Zoom
George Muprhy, Testing
Michael Ieong & James Murphy, Operation Update
Ariella Krones
Mallory LeSuer
4/8
Zoom
Michael Ieong & James Murphy, Operations
Ehab Billatos, Anesthesia Vents
Andrew Wilson, CCCL (COVID Critical Care Liaison) Group
Nick Bosch,  ICU Toolkit
Erin Crossey
Caitlin Butler
4/15
Zoom
Shelsey Johnson
“COVID-19 Case Presentation: Cardiac Complications of COVID-19”
Michael Ieong
ICU Updates
4/22
Zoom
Michael Ieong & James Murphy
“ICU Operations”
Kate Steingberg & Liz Klings
“Clinical Review: Is COVID-19 Associated with a Hypercoagulable State?”
4/29
Zoom
Finn Hawkins
“CPC Presentation of Two Patients with Fatal COVID-19 Clinical Cases”
Eric Burks, Pathology Department
“Pathologic Findings”
5/6
Zoom
Jeffrey Browning & Jennifer Snyder-Cappione
“Pre-Clinical COVID-19 Serology Testing”
5/13
Zoom
Jack Iwashyna, University of Michigan
“COVID Post-ICU Care & the Michigan COVID Experience”
Mike Garcia,  BMC COVID Patient Registry
James Murphy & Michael Ieong, Operations Update
5/20
Zoom
Alicia Soucy
5/27
Zoom
Tachiro Pichardo
6/3
Zoom
Jake Le Seur
6/10
Zoom
Jessica Gereige
6/17
Zoom
Fellows Graduation
6/24
Zoom
Sputum Bowl
7/1
Zoom
Jin Yuan
7/8
Zoom
Sheng Si
7/15
Zoom
Adeline Matschulat
7/22
Zoom
Elim Na
7/29 Kiloni Quiles-Franco

Work in Progress Spring/Summer 2019 Schedule:

Date Speaker Presentation Title
1/4 Michael Herriges/Yuri Kim “Transplantation of primary and PSC-derived lung epithelial progenitor cells”
1/11 Renda Wiener “Untangling overuse: PDE-5-inhibitors for Groups 2/3 Pulmonary Hypertension”
1/18 Sarah Mazzilli

“Molecular Characterization of a Pre-Clinical Model for Lung Cancer Interception”

1/25 Kim Barker/Andrew Berical Pneumococcal exposures elicit resident memory B cells poised to secrete class-switched antibodies in the lung”

“Induced Pluripotent Stem Cells and Personalized Cystic Fibrosis Drug Prediction”

2/1 Hannah Wunsch, University of Toronto “ICU staffing models: do they make a difference?”
2/8 Judy Campisi- Jerome Brody Lecture “Cellular Senescence, the Lung and Aging: The Jerry Brody Connection”
2/15 Kristine Abo/Sean Corbett “Pluripotent Stem Cell-Based Modeling of Cigarette Smoke Injury”

“Identifying Lung-Cell-Type-Associated Responses to Compound Perturbation”

2/22 Emad Arafa/Nathan Kingston “Alveolar Macrophages Dynamics During Pneumococcal Pneumonia”

“Roles for Hippo Pathway Effectors Taz and Yap in Fibroblast Populations During Pulmonary Fibrosis”

3/1 Anukul Shenoy/ Filiz Korkmaz “Lung-Resident CD4+ Memory T Cell and Epithelial Crosstalk During Heterotypic Immunity”
3/8 Roberto Machado, Indiana University School of Medicine “NAMPT and pulmonary vascular remodeling in PAH”
3/15 Jussi Saukkonen “Phenobarbital in the treatment of acute alcohol withdrawal syndrome”
3/22 Claire Burgess/Julia Hicks-Berthet “Generation of human alveolar epithelial type 1 cells from pluripotent stem cells”

“Yap and Taz-regulated control of goblet cell fate in the airway epithelium”

3/29 Barbara Ludeke/Michael Breen “Towards a linked RNA synthesis and RNA capping assay for RSV”

“Characterizing the lung B memory cell population after respiratory viral infection”

4/5 Bela Suki “Bioengineering approaches toward understanding honeycombing in pulmonary fibrosis and tissue deterioration in emphysema”
4/12 Kari Gillmeyer/Yuliang (Leon) Sun “Delivery of care for patients with pulmonary hypertension”

“Establishing an iPSC-derived AEC2s model to study childhood interstitial lung disease”

4/19 Alicia Wooten/Stephanie Hon “Phosphodiesterase 2 deletion in Streptococcus pneumoniae D39 elicits a robust type I interferon response in macrophages”

“Single Cell Sequencing and Lineage Tracing of the Origins of Pulmonary Vasculature”

4/26 Nick Bosch/Rhiannon Werder “Derivation and Validation of a Novel Measure of Septic Shock Severity”

“Understanding the Function of COPD Susceptibility Genes using CRISPRi-Targeted Human Induced Pluripotent Stem Cell (iPSC)-Derived Lung Epithelium”

5/3 James Murphy, M.D. “Critical Care Quality Improvement at BMC”
5/10 Eric Abston/ Ming-Ming Lee “Noninvasive Quantification of Fibrotic Lung Disease: of Mice and Men”

“Predicting future pneumonia from baseline clinical risk factors and blood protein markers”

5/17 No Seminar- ATS TBD
5/24 No Seminar- ATS TBD
5/31 Avi Spira- Mary Williams Lecture “The Road Rarely Traveled: a 20-year Journey Towards Early Lung Cancer Detection.”
6/7 Timothy Blackwell, Vanderbilt University Medical Center – Gordon Snider Memorial Lecture “Progress in Understanding Genetic Mechanisms of Pulmonary Fibrosis.”
6/14 Tien Peng- UCSF “Traversing the Wall: Signaling Across the Basement Membrane in Lung Regeneration.”
6/21 Elim Na/Carolina Lyon De Ana “Determining epithelial-specific roles for the lung-protective cytokine LIF during pneumonia.”

“The T-lymphocytic landscape of heterotypic immune lungs.”

6/28 Kostas Alysandratos “Pluripotent stem cells to unravel the role of alveolar type 2 epithelial cells in the pathogenesis of pulmonary fibrosis.”
7/5 No Seminar
7/12 Christine Odom/Adeline Matsculat “Liver-dependent lung defense during sepsis.”

“Defining molecular signals that influence airway basal cell renewal and growth.”

7/19 Barbara Ludeke “Towards a High Throughput Screening Assay for Multiple Activities of RSV RNA Polymerase.”
7/26 Alan Fine “Lung Lymphatic Remodeling”