Lipid Antigens for Tuberculosis

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

A collaboration in immunology…

A recent article collaborating with Prof. Branch Moody

Mass Spectrometry was used to identify and structurally define a previously unknown lipid antigen isolated from tuberculosis bacteria.  Both low energy CID MS/MS and high energy CID with accurate mass measurement were used for determination of the pseudo-isoprenoid structure of the lipid chain.  The structure of the saccharide moiety was determined by permethylation followed by GCMS for determination of the substitution pattern.  

For more information, please visit www.nature.com, or contact Cathy Costello for reprints.