Lipid Antigens for Tuberculosis

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

A collaboration in immunology…

lipid antigens nature cover

A recent article collaborating with Prof. Branch Moody

Mass Spectrometry was used to identify and structurally define a previously unknown lipid antigen isolated from tuberculosis bacteria.  Both low energy CID MS/MS and high energy CID with accurate mass measurement were used for determination of the pseudo-isoprenoid structure of the lipid chain.  The structure of the saccharide moiety was determined by permethylation followed by GCMS for determination of the substitution pattern.  

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