Lipid Antigens for Tuberculosis
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
A collaboration in immunology…
A recent article collaborating with Prof. Branch Moody
Mass Spectrometry was used to identify and structurally define a previously unknown lipid antigen isolated from tuberculosis bacteria. Both low energy CID MS/MS and high energy CID with accurate mass measurement were used for determination of the pseudo-isoprenoid structure of the lipid chain. The structure of the saccharide moiety was determined by permethylation followed by GCMS for determination of the substitution pattern.