Publications (Selected)
For up dated publications, please visit http://www.ncbi.nlm.nih.gov/pubmed/?term=sam+f
El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2022 Nov 11;24(1):251. doi: 10.1186/s13075-022-02943-2.
Valero-Muñoz M, Saw EL, Hekman RM, Blum BC, Hourani Z, Granzier H, Emili A, Sam F. Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF). Front Cardiovasc Med. 2022 Aug 25;9:966968. doi: 10.3389/fcvm.2022.966968. eCollection 2022
Roh J, Hill JA, Singh A, Valero-Muñoz M, Sam F. Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models. Circ Res. 2022 Jun 10;130(12):1906-1925. doi: 10.1161/CIRCRESAHA.122.320257.
Valero-Muñoz M, Sam F. A misdirected conundrum in translational HFpEF research. J Mol Cell Cardiol. 2022 Jul;168:1-2. doi: 10.1016/j.yjmcc.2022.04.003.
Pandey A, Shah SJ, Butler J, Kellogg DL Jr, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Sep 14;78(11):1166-1187. doi: 10.1016/j.jacc.2021.07.014.
Valero-Muñoz M, Oh A, Faudoa E, Bretón-Romero R, El Adili F, Bujor A, Sam F. Endothelial-Mesenchymal Transition in Heart Failure With a Preserved Ejection Fraction: Insights Into the Cardiorenal Syndrome. Circ Heart Fail. 2021 Sep;14(9):e008372. doi: 10.1161/CIRCHEARTFAILURE.121.008372
Saw EL, Ramachandran S, Valero-Muñoz M, Sam F. Skeletal muscle (dys)function in heart failure with preserved ejection fraction. Curr Opin Cardiol. 2020 Dec 24. doi: 10.1097/HCO.0000000000000824.
Valero-Muñoz M, Wilson RM, Bretón-Romero R, Croteau D, Seldin DC, Sam F. Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes. Int J Cardiol. 2020 Dec 15;321:133-136. doi: 10.1016/j.ijcard.2020.07.016.
Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB. Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Circulation. 2020 Mar 24;141(12):1001-1026. doi: 10.1161/CIRCULATIONAHA.119.041886.
Butt SA, Jeppesen JL, Torp-Pedersen C, Sam F, Gislason GH, Jacobsen S, Andersson C. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study. J Am Heart Assoc. 2019 Sep 3;8(17):e013405. doi: 10.1161/JAHA.119.013405.
Oh A, Okazaki R, Sam F, Valero-Muñoz M. Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales. Front Cardiovasc Med. 2019 Aug 2;6:110. doi: 10.3389/fcvm.2019.00110. eCollection 2019. Review.
Tahir UA, Doros G, Kim JS, Connors LH, Seldin DC, Sam F. Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure. Sci Rep. 2019 Jun 12;9(1):8552. doi: 10.1038/s41598-019-44912-x.
Yunis A, Doros G, Luptak I, Connors LH, Sam F. Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis. Am J Cardiol. 2019 Jul 1;124(1):122-130. doi: 10.1016/j.amjcard.2019.03.035. Epub 2019 Apr 9.
Pimental DR, Sam F. Is Protein Kinase C Inhibition the Tip of the Iceberg in New Therapeutics for Acutely Decompensated Heart Failure? JACC Basic Transl Sci. 2017 Dec 25;2(6):684-687. doi: 10.1016/j.jacbts.2017.11.005. eCollection 2017 Dec.
Valero-Muñoz M, Sam F. Reply: Diet-Induced Obesity HFpEF Murine Models. JACC Basic Transl Sci. 2018 Mar 1;3(1):158-159. doi: 10.1016/j.jacbts.2018.01.006. eCollection 2018 Feb.
Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 Feb 5;215(2):423-440. doi: 10.1084/jem.20171274. Epub 2018 Jan 16.
Valero-Muñoz M, Backman W, Sam F. Murine Models of Heart Failure with Preserved Ejection Fraction: a “Fishing Expedition”. JACC Basic Transl Sci. 2017 Dec;2(6):770-789. doi: 10.1016/j.jacbts.2017.07.013. Epub 2017 Dec 25.
Valero-Munoz M, Li S, Wilson RM, Boldbaatar B, Iglarz M, Sam F. Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Nov;9(11). pii: e003381.
Tanaka K, Valero-Muñoz M, Wilson RM, Essick EE, Fowler CT, Nakamura K, van den Hoff M, Ouchi N, Sam F. Follistatin like 1 Regulates Hypertrophy in Heart Failure with Preserved Ejection Fraction. JACC Basic Transl Sci. 2016 Jun;1(4):207-221.
Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan;9(1):e002724.
Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19;133(3):282-90.
Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2015 Nov 20. pii: S0022-2828(15)30120-6.
Tahir U, Sam F. Withdrawal of heart failure medications in peripartum cardiomyopathy after myocardial recovery. Int J Cardiol. 2015 Jul 1;190:212-3.
Tahir U, Doros G, Sam F. Delayed myocardial recovery in peripartum cardiomyopathy. Int J Cardiol. 2015 Apr 1;184:310-2.
Brogan A, Ding Y, Pimentel DR, Sam F. Non-invasive imaging for cardiac amyloidosis – delaying the obvious? Int J Cardiol. 2014 Dec 15;177(2):e87-9.
Tanaka K, Wilson RM, Essick EE, Duffen JL, Scherer PE, Ouchi N, Sam F. Effects of Adiponectin on Calcium Handling Proteins in Heart Failure with Preserved Ejection Fraction. Circ Heart Fail. 2014 Aug 22. pii: CIRCHEARTFAILURE.114.001279. [Epub ahead of print]
Quiroz R, Doros G, Shaw P, Liang CS, Gauthier DF, Sam F. Comparison of characteristics and outcomes of patients with heart failure preserved ejection fraction versus reduced left ventricular ejection fraction in an urban cohort. Am J Cardiol. 2014 Feb 15;113(4):691-6. doi: 10.1016/j.amjcard.2013.11.014. Epub 2013 Nov 23.
Essick EE, Wilson RM, Pimentel DR, Shimano M, Baid S, Ouchi N, Sam F. Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes. PLoS One. 2013 Jul 19;8(7):e68697. doi: 10.1371/journal.pone.0068697. Print 2013.
Ayalon N, Flore LA, Christensen TG, Sam F. Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy. Int J Cardiol. 2013 Sep 1;167(5):e143-5. doi: 10.1016/j.ijcard.2013.04.018. Epub 2013 Apr 28.
Tanaka K, Essick EE, Doros G, Tanriverdi K, Connors LH, Seldin DC, Sam F. Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis. J Am Heart Assoc. 2013 Mar 12;2(2):e005868. doi: 10.1161/JAHA.112.005868.
Garcia AG, Wilson RM, Heo J, Murthy NR, Baid S, Ouchi N, Sam F. Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure. Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H587-96. doi: 10.1152/ajpheart.00298.2012. Epub 2012 Jun 22.
Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K. Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E899-906. doi: 10.1073/pnas.1108559108. Epub 2011 Oct 10.
Essick EE, Ouchi N, Wilson RM, Ohashi K, Ghobrial J, Shibata R, Pimentel DR, Sam F. Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H984-93. doi: 10.1152/ajpheart.00428.2011. Epub 2011 Jun 10.
El-Armouche A, Ouchi N, Tanaka K, Doros G, Wittköpper K, Schulze T, Eschenhagen T, Walsh K, Sam F. Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling. Circ Heart Fail. 2011 Sep;4(5):621-7. doi: 10.1161/CIRCHEARTFAILURE.110.960625. Epub 2011 May 27.
Greene MJ, Sam F, Soo Hoo PT, Patel RS, Seldin DC, Connors LH. Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy. Am J Pathol. 2011 Jan;178(1):61-8. doi: 10.1016/j.ajpath.2010.11.015. Epub 2010 Dec 23.
Quiroz R, Joseph L, Sam F. Serial troponin-I measurement as a diagnostic and therapeutic tool in chronic myocarditis. J Heart Lung Transplant. 2010 Jul;29(7):820-2. doi: 10.1016/j.healun.2010.03.006. Epub 2010 Apr 22.
Biolo A, Shibata R, Ouchi N, Kihara S, Sonoda M, Walsh K, Sam F. Determinants of adiponectin levels in patients with chronic systolic heart failure. Am J Cardiol. 2010 Apr 15;105(8):1147-52. doi: 10.1016/j.amjcard.2009.12.015. Epub 2010 Feb 20.
Sam F, Duhaney TA, Sato K, Wilson RM, Ohashi K, Sono-Romanelli S, Higuchi A, De Silva DS, Qin F, Walsh K, Ouchi N. Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. Endocrinology. 2010 Jan;151(1):322-31. doi: 10.1210/en.2009-0806. Epub 2009 Oct 22.
Biolo A, Ramamurthy S, Connors LH, O’Hara CJ, Meier-Ewert HK, Soo Hoo PT, Sawyer DB, Seldin DC, Sam F. Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition. Circ Heart Fail. 2008 Nov;1(4):249-57. doi: 10.1161
Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F. Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. Hypertension. 2009 Sep;54(3):583-90. doi: 10.1161/HYPERTENSIONAHA.109.134932. Epub 2009 Jul 20.
De Silva DS, Wilson RM, Hutchinson C, Ip PC, Garcia AG, Lancel S, Ito M, Pimentel DR, Sam F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1983-93. doi: 10.1152/ajpheart.00002.2009. Epub 2009 Apr 24.
1: Essick EE, Sam F. Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev. 2010 May-Jun;3(3):168-77. PubMed PMID: 20716941. 2: Sam F, Walsh K. What can adiponectin say about left ventricular function? Heart. 2010 Mar;96(5):331-2. Epub 2009 Nov 23. PubMed PMID: 19934101. 3: Sam F, Duhaney TA, Sato K, Wilson RM, Ohashi K, Sono-Romanelli S, Higuchi A, De Silva DS, Qin F, Walsh K, Ouchi N. Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. Endocrinology. 2010 Jan;151(1):322-31. Epub 2009 Oct 22. PubMed PMID: 19850745; PubMed Central PMCID: PMC2803144. 4: Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F. Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. Hypertension. 2009 Sep;54(3):583-90. Epub 2009 Jul 20. PubMed PMID: 19620510. 5: De Silva DS, Wilson RM, Hutchinson C, Ip PC, Garcia AG, Lancel S, Ito M, Pimentel DR, Sam F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1983-93. Epub 2009 Apr 24. PubMed PMID: 19395558; PubMed Central PMCID: PMC2716095.
