Research

The department of cardiology is committed to cutting edge basic science and clinical research. We have many ongoing trials, NIH grants, and renowned labs within our institution.

Section of Cardiovascular Medicine recent publications:

November 2022

Prognostic Importance of Atrial Fibrillation and Anticoagulation in Alcoholic Versus Dilated Cardiomyopathy.

Manivannan A, Schou M, Monahan KM, Helm R, Ko D, Fosbøl E, Køber L, Gustafsson F, Gislason GH, Torp-Pedersen C, Andersson C.

Alcohol Alcohol. 2022 Nov 24:agac060. doi: 10.1093/alcalc/agac060. Online ahead of print.

PMID: 36426877

Optimal Echocardiographic Parameters to Improve the Diagnostic Yield of Tc-99m-Bone Avid Tracer Cardiac Scintigraphy for Transthyretin Cardiac Amyloidosis.

Cuddy SA, Datar Y, Ovsak G, Saith S, Murphy SP, Bay CP, Haddad M, Lilleness B, Muralidhar V, Pipilas A, Vuong J, Guardino E, Maurer MS, Ruberg FL, Falk RH, Dorbala S.

Circ Cardiovasc Imaging. 2022 Nov;15(11):e014645. doi: 10.1161/CIRCIMAGING.122.014645. Epub 2022 Nov 15.

PMID: 36378779

The role of invasive cardiopulmonary exercise testing in patients with unexplained dyspnea: a systemic review.

Behrooz L, Barillas-Lara M, Fattouh M, Loubeau B, Ibrahim M.

Acta Cardiol. 2022 Nov 8:1-7. doi: 10.1080/00015385.2022.2141434. Online ahead of print.

PMID: 36345986 Review.

Identification of Transthyretin Cardiac Amyloidosis Among Patients Previously Diagnosed With Hypertrophic Cardiomyopathy.

Rowin EJ, Ruberg FL, Das G, Higgins D, Lipe WC, Bokhari N, Dehn M, Maron BJ, Maron MS.

Circ Cardiovasc Imaging. 2022 Nov 30:e014938. doi: 10.1161/CIRCIMAGING.122.014938. Online ahead of print.

PMID: 36448453 No abstract available.

Outcomes by Cardiac Stage in Patients With Newly Diagnosed AL Amyloidosis: Phase 3 ANDROMEDA Trial.

Minnema MC, Dispenzieri A, Merlini G, Comenzo RL, Kastritis E, Wechalekar AD, Grogan M, Witteles R, Ruberg FL, Maurer MS, Tran N, Qin X, Vasey SY, Weiss BM, Vermeulen J, Jaccard A.

JACC CardioOncol. 2022 Nov 15;4(4):474-487. doi: 10.1016/j.jaccao.2022.08.011. eCollection 2022 Nov.

PMID: 36444227 Free PMC article.

Dietary metabolic signatures and cardiometabolic risk.

Shah RV, Steffen LM, Nayor M, Reis JP, Jacobs DR, Allen NB, Lloyd-Jones D, Meyer K, Cole J, Piaggi P, Vasan RS, Clish CB, Murthy VL.

Eur Heart J. 2022 Nov 25:ehac446. doi: 10.1093/eurheartj/ehac446. Online ahead of print.

PMID: 36424694

The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study.

Kornej J, Qadan MA, Alotaibi M, Van Wagoner DR, Watrous JD, Trinquart L, Preis SR, Ko D, Jain M, Benjamin EJ, Cheng S, Lin H.

Sci Rep. 2022 Nov 23;12(1):20218. doi: 10.1038/s41598-022-21786-0.

PMID: 36418854 Free PMC article.

Digital Connectedness in the Jackson Heart Study: Cross-sectional Study.

Anugu P, Ansari MAY, Min YI, Benjamin EJ, Murabito J, Winters K, Turner E, Correa A.

J Med Internet Res. 2022 Nov 21;24(11):e37501. doi: 10.2196/37501.

PMID: 36409531

Relations of postural change in blood pressure with hypertension-mediated organ damage in middle-aged adults of the Framingham heart study: A cross-sectional study.

Cooper LL, Rong J, Maillard P, Beiser A, Hamburg NM, Larson MG, DeCarli C, Vasan RS, Seshadri S, Mitchell GF.

Front Cardiovasc Med. 2022 Nov 1;9:1013876. doi: 10.3389/fcvm.2022.1013876. eCollection 2022.

PMID: 36386360 Free PMC article.

Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications.

Nayor M, Gajjar P, Murthy VL, Miller P, Velagaleti RS, Larson MG, Vasan RS, Lewis GD, Mitchell GF, Shah RV.

Arterioscler Thromb Vasc Biol. 2022 Nov 17. doi: 10.1161/ATVBAHA.122.318512. Online ahead of print.

PMID: 36384270

Emergency Interhospital Transfer of Patients With ST-Segment-Elevation Myocardial Infarction: Call 9-1-1-The American Heart Association Mission: Lifeline Program.

French WJ, Gunderson M, Travis D, Bieniarz M, Zegre-Hemsey J, Goyal A, Jacobs AK.

J Am Heart Assoc. 2022 Nov 15;11(22):e026700. doi: 10.1161/JAHA.122.026700. Epub 2022 Nov 12.

PMID: 36370009

Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications.

El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM.

Arthritis Res Ther. 2022 Nov 11;24(1):251. doi: 10.1186/s13075-022-02943-2.

PMID: 36369212 Free PMC article.

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021.

Jollis JG, Granger CB, Zègre-Hemsey JK, Henry TD, Goyal A, Tamis-Holland JE, Roettig ML, Ali MJ, French WJ, Poudel R, Zhao J, Stone RH, Jacobs AK.

JAMA. 2022 Nov 22;328(20):2033-2040. doi: 10.1001/jama.2022.20149.

PMID: 36335474

Systematic dissection, preservation, and multiomics in whole human and bovine hearts.

Moreira JD, Gower AC, Xue L, Alekseyev Y, Smith KK, Choi SH, Ayalon N, Farb MG, Tenan K, LeClerc A, Levy D, Benjamin EJ, Lenburg ME, Mitchell RN, Padera RF, Fetterman JL, Gopal DM.

Cardiovasc Pathol. 2022 Nov 2;63:107495. doi: 10.1016/j.carpath.2022.107495. Online ahead of print.

PMID: 36334690

The inflammatory proteome, obesity, and medical weight loss and regain in humans.

Perry AS, Tanriverdi K, Risitano A, Hwang SJ, Murthy VL, Nayor M, Zhao S, Levy D, Shah RV, Freedman JE.

Obesity (Silver Spring). 2022 Nov 5. doi: 10.1002/oby.23587. Online ahead of print.

PMID: 36334095

Characterization of Ventilatory Efficiency During Cardiopulmonary Exercise Testing in Healthy Athletes.

Petek BJ, Churchill TW, Gustus SK, Schoenike MW, Nayor M, Moulson N, Guseh JS, VanAtta C, Blodgett JB, Contursi M, Lewis GD, Baggish AL, Wasfy MM.

Eur J Prev Cardiol. 2022 Nov 2:zwac255. doi: 10.1093/eurjpc/zwac255. Online ahead of print.

PMID: 36321382 No abstract available

October 2022

Cardiovascular Morbidity in Monoclonal Gammopathy of Undetermined Significance: A Danish Nationwide Study.

Schwartz B, Schou M, Ruberg FL, Rucker D, Choi J, Siddiqi O, Monahan K, Køber L, Gislason G, Torp-Pedersen C, Andersson C.JACC CardioOncol. 2022 Jul 19;4(3):313-322. doi: 10.1016/j.jaccao.2022.05.009. eCollection 2022 Sep.PMID: 36213365 Free PMC article.

Transcatheter Aortic Valve Replacement for Severe Symptomatic Aortic Stenosis in Rheumatic Heart Disease: A Systematic Review.

Fernandes ADF, Fernandes GC, Grant J, Knijnik L, Cardoso R, Cohen MG, Ferreira AC, Alfonso CE. Cardiol

Rev. 2022 Nov-Dec 01;30(6):318-323. doi: 10.1097/CRD.0000000000000425.

Epub 2021 Oct 18.PMID: 36201243

Achalasia as an Unusual Cause of Acute Cellular Rejection of a Transplanted Heart.

Fernandes A, Yan CL, Ruiz P, Thakkar Rivera N.

Case Rep Cardiol. 2022 Sep 28;2022:2054727. doi: 10.1155/2022/2054727. eCollection 2022.

PMID: 36254142 Free PMC article.

Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.

Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML.

Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1333-1350. doi: 10.1161/ATVBAHA.121.317749. Epub 2022 Oct 26.

PMID: 36288290

Association of Race and Ethnicity With Oral Anticoagulation and Associated Outcomes in Patients With Atrial Fibrillation: Findings From the Get With The Guidelines-Atrial Fibrillation Registry.

Essien UR, Chiswell K, Kaltenbach LA, Wang TY, Fonarow GC, Thomas KL, Turakhia MP, Benjamin EJ, Rodriguez F, Fang MC, Magnani JW, Yancy CW, Piccini JP Sr.

JAMA Cardiol. 2022 Oct 26. doi: 10.1001/jamacardio.2022.3704. Online ahead of print.

PMID: 36287545

Endothelial-Specific Expression of CIDEC Improves High-Fat Diet-Induced Vascular and Metabolic Dysfunction.

Balakrishnan B, Gupta A, Basri R, Sharma VM, Slayton M, Gentner K, Becker CC, Karki S, Muturi H, Najjar SM, Loria AS, Gokce N, Puri V.

Diabetes. 2022 Oct 18:db220294. doi: 10.2337/db22-0294. Online ahead of print.

PMID: 36256836

Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community.

Gonzalez Izundegui D, Miller PE, Shah RV, Clish CB, Walker ME, Mitchell GF, Gerszten RE, Larson MG, Vasan RS, Nayor M.

Cardiovasc Diabetol. 2022 Oct 15;21(1):213. doi: 10.1186/s12933-022-01647-w.

PMID: 36243866 Free PMC article.

September 2022

Prognostic importance of atrial fibrillation in heart failure according to time elapsed since diagnosis.

Schwartz B, Schou M, Barrillas Lara IM, Monahan K, Helm R, Køber L, Gislason GH, Ramachandran VS, Torp-Pedersen C, Andersson C.
Heart Rhythm O2. 2022 May 5;3(4):430-432. doi: 10.1016/j.hroo.2022.04.008. eCollection 2022 Aug.
PMID: 36097453 Free PMC article. No abstract available

A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis.

Rosalia L, Ozturk C, Coll-Font J, Fan Y, Nagata Y, Singh M, Goswami D, Mauskapf A, Chen S, Eder RA, Goffer EM, Kim JH, Yurista S, Bonner BP, Foster AN, Levine RA, Edelman ER, Panagia M, Guerrero JL, Roche ET, Nguyen CT.
Nat Biomed Eng. 2022 Sep 26. doi: 10.1038/s41551-022-00937-8. Online ahead of print.
PMID: 36163494

Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF).

Valero-Muñoz M, Saw EL, Hekman RM, Blum BC, Hourani Z, Granzier H, Emili A, Sam F.

Front Cardiovasc Med. 2022 Aug 25;9:966968. doi: 10.3389/fcvm.2022.966968. eCollection 2022.

PMID: 36093146 Free PMC article.

Blood-Based Fingerprint of Cardiorespiratory Fitness and Long-Term Health Outcomes in Young Adulthood.

Shah RV, Miller P, Colangelo LA, Chernofsky A, Houstis NE, Malhotra R, Velagaleti RS, Jacobs DR Jr, Gabriel KP, Reis JP, Lloyd-Jones DM, Clish CB, Larson MG, Vasan RS, Murthy VL, Lewis GD, Nayor M.
J Am Heart Assoc. 2022 Sep 20;11(18):e026670. doi: 10.1161/JAHA.122.026670. Epub 2022 Sep 8.
PMID: 36073631

Wearable accelerometer-derived physical activity and incident disease.

Khurshid S, Weng LC, Nauffal V, Pirruccello JP, Venn RA, Al-Alusi MA, Benjamin EJ, Ellinor PT, Lubitz SA.
NPJ Digit Med. 2022 Sep 2;5(1):131. doi: 10.1038/s41746-022-00676-9.
PMID: 36056190 Free PMC article.

August 2022

Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes – PubMed (nih.gov)

Halford JL, Morrill VN, Choi SH, Jurgens SJ, Melloni G, Marston NA, Weng LC, Nauffal V, Hall AW, Gunn S, Austin-Tse CA, Pirruccello JP, Khurshid S, Rehm HL, Benjamin EJ, Boerwinkle E, Brody JA, Correa A, Fornwalt BK, Gupta N, Haggerty CM, Harris S, Heckbert SR, Hong CC, Kooperberg C, Lin HJ, Loos RJF, Mitchell BD, Morrison AC, Post W, Psaty BM, Redline S, Rice KM, Rich SS, Rotter JI, Schnatz PF, Soliman EZ, Sotoodehnia N, Wong EK; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Sabatine MS, Ruff CT, Lunetta KL, Ellinor PT, Lubitz SA. Nat Commun. 2022 Aug 30;13(1):5106. doi: 10.1038/s41467-022-32009-5.

PMID: 36042188

Using Point-of-Care Ultrasound in Heart Failure Diagnosis and Management in Rural and Resource-Limited Settings – PubMed (nih.gov)

Klassen SL, Dusingizimana W, Ngoga G, Kamali I, Dusabeyezu S, Ntaganda E, Kwan GF.

CASE (Phila). 2022 Aug 15;6(6):259-262. doi: 10.1016/j.case.2022.04.012. eCollection 2022 Aug.

PMID: 36036046 Free PMC article.

Light Chain Testing Abnormalities Among Patients With Transthyretin Amyloid Cardiomyopathy Referred for Technetium-99m Pyrophosphate Imaging.

Alreshq R, Cozzolino M, Lilleness B, Pipilas A, Mendelson L, Joshi T, Muralidhar V, Guardino E, Berk JL, Siddiqi OK, Gopal DM, Sanchorawala V, Ruberg FL.

Am J Cardiol. 2022 Aug 23:S0002-9149(22)00755-X. doi: 10.1016/j.amjcard.2022.06.064. Online ahead of print.

PMID: 36028388

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, Pampana A, Robbins JM, Yu Z, Chen ZZ, Benson MD, Cruz DE, Ngo D, Deng S, Shi X, Zheng S, Eisman AS, Farrell L, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen YI, Manichaikul AW, Ruberg FL, Blaner WS, Jain D; NHLBI Trans-Omics for Precision Medicine 1 Consortium, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Natarajan P, Gerszten RE.

Nat Commun. 2022 Aug 22;13(1):4923. doi: 10.1038/s41467-022-32275-3.

PMID: 35995766 Free PMC article.

Human CIDEC transgene improves lipid metabolism and protects against high-fat diet-induced glucose intolerance in mice.

Gupta A, Balakrishnan B, Karki S, Slayton M, Jash S, Banerjee S, Grahn THM, Jambunathan S, Disney S, Hussein H, Kong D, Lowell BB, Natarajan P, Reddy UK, Gokce N, Sharma VM, Puri V.

J Biol Chem. 2022 Aug 10:102347. doi: 10.1016/j.jbc.2022.102347. Online ahead of print.

PMID: 35963433

Mediation effects of diabetes and inflammation on the relationship of obesity to cognitive impairment in African Americans.

Abi Saleh R, Lirette ST, Benjamin EJ, Fornage M, Turner ST, Hammond PI, Mosley TH, Griswold ME, Windham BG.

J Am Geriatr Soc. 2022 Aug 8. doi: 10.1111/jgs.17985. Online ahead of print.

PMID: 35941823 Review.

Prospective association between e-cigarette use frequency patterns and cigarette smoking abstinence among adult cigarette smokers in the United States.

Harlow AF, Stokes AC, Brooks DR, Benjamin EJ, Leventhal AM, McConnell RS, Barrington-Trimis JL, Ross CS.

Addiction. 2022 Aug 1. doi: 10.1111/add.16009. Online ahead of print.

PMID: 35913015

E-cigarette use among high school students in the United States prior to the COVID-19 pandemic: Trends, correlates, and sources of acquisition.

Mirbolouk M, Boakye E, Obisesan O, Osei AD, Dzaye O, Osuji N, Erhabor J, Stokes AC, El-Shahawy O, Rodriguez CJ, Hirsch GA, Benjamin EJ, DeFilippis AP, Marie Robertson R, Bhatnagar A, Blaha MJ. Prev Med Rep. 2022 Jul 22;29:101925. doi: 10.1016/j.pmedr.2022.101925. eCollection 2022 Oct.

PMID: 35911577 Free PMC article.

Archived Publications:

CVM Publications Q1-2021

CVM Publications Q4-2020

November 2022

October 2022

September 2022

August 2022

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