Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.
YAP/TAZ integrate cell polarity and mechanical cues with cytokine signals to direct organ development and homeostasis. The lab utilizes molecular and genetic approaches to define how YAP/TAZ control developmental processes, gain insight into the mechanisms by which YAP/TAZ are regulated, and determine how dysregulated YAP/TAZ activity contributes to the etiology of various diseases, such as cancer.
Andrew Tilston-Lunel – Postdoctoral Associate
Julia Hicks-Berthet – Graduate Student
Joseph Kern – Graduate Student
Nathan Kingston – Graduate Student
Adeline Matschulat – Graduate Student
Christina Noe – Research Technician
Eleni Stampouloglou – Graduate Student
Complete List of Published Work in MyBibliography
- Yang CS, Stampouloglou E, Kingston NM, Zhang L, Monti S, Varelas X. Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. EMBO reports. 2018; [Epub ahead of print] View in: Pubmed
- Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X. The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland. Elife. 2017 May 11;6. pii: e23499. doi: 10.7554/eLife.23499. [Epub ahead of print] PMID: 28492365. View in: PubMed
Jorgenson AJ, Choi KM, Sicard D, Smith KM, Hiemer SE, Varelas X, Tschumperlin DJ. TAZ activation drives fibroblast spheroid growth, expression of pro-fibrotic paracrine signals, and context dependent ECM gene expression. Am J Physiol Cell Physiol. 2016 Nov 23; ajpcell.00205.2016. PMID: 27881410.
View in: PubMed
Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96. PMID: 26235047. View in: PubMed
Hiemer SE, Zhang L, Kartha VK, Packer TS, Almershed M, Noonan V, Kukuruzinska M, Bais MV, Monti S, Varelas X. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Mol Cancer Res. 2015 Jun; 13(6):957-68. PMID: 25794680. View in: PubMed
Liu F, Lagares D, Choi KM, Stopfer L, Marinkovic A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15; 308(4):L344-57. PMID: 25502501. View in: PubMed
Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014 Jul 28; 30(2):137-50. PMID: 25043473. View in: PubMed
Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development. 2014 Apr; 141(8):1614-26. PMID: 24715453. View in: PubMed
Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor ß-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem. 2014 May 9; 289(19):13461-74. PMID: 24648515. View in: PubMed
More information in my BU Profiles