The Perissi Lab has received a new NIGMS Maximizing Investigator’s Research Award (MIRA) to investigate the “Coordination of PAR and Ub signaling in mitochondria”. Research supported by the R35GM149339 award will investigate the spatial and functional regulation of mitochondria retrograde signaling in response to mitochondrial stress and explore the crosstalk between ubiquitination and ADP-ribosylation in regulating mitochondrial homeostasis. Successful completion of the proposed studies will lead to a better understanding of the mechanisms regulating metabolic adaptation to mitochondrial stress and possibly reveal novel pathways to target for therapeutic purposes.