Congratulations to the Varelas Lab for their recent publication in Developmental Cell. Aleks Szymaniak, a PhD candidate in the Varelas lab, found that the apical polarity determinant Crb3 is an essential regulator of airway cell maturation and that Crb3 scaffolds Hippo pathway components at the apical domain of epithelial cells to restrict the nuclear activity of the transcriptional regulator Yap, and showed that loss of Crb3 results in aberrant airway cell maturation.