CReM Lecture: Targeted Genome Modification Using Engineered Zinc Finger Nucleases, Dec. 7
Join the Center for Regenerative Medicine (CReM) on Tuesday, Dec. 7 as it hosts Dr. J. Keith Joung, Associate Professor of Pathology at Harvard Medical School and Associate Chief of Pathology for Research at Massachusetts General Hospital. Dr. Joung also serves as the Director of the Molecular Pathology Unit at Massachusetts General Hospital.
Dr. Joung’s lecture on the BU Medical Campus will focus on Targeted Genome Modification Using Engineered Zinc Finger Nucleases. His laboratory studies zinc finger nucleases, a common domain in the genomes of organisms across the evolutionary spectrum, and their potential for genome modifications and expression changes in the cell. A particular focus of his lab is on the correction of genetic mutations associated with disease, such as the CFTR gene in lung epithelial cells, the mutation of which leads to cystic fibrosis. His lab also spearheaded the “Oligomerization Pool Engineering” (OPEN) project, a publicly available method for creating zinc-finger domains. This method has been used to specifically modify genetic domains in human ES and iPS cells as well as several other cell types.
The CReM is a collaborative effort among scientists on the Medical and Charles River campuses of Boston University that aims to advance stem cell research and regenerative medicine, particularly for the benefit of patients afflicted with diseases seen at Boston Medical Center (BMC). The Center’s monthly Seminar Series brings the leading minds in stem cell research to BUMC. Some of the past speakers have included George Daley, Rudolf Jaenisch and Doug Melton.
Learn more on Tuesday, December 7, 2010 at 9 a.m. with Dr. Joung in the Evans Biomedical Research Center, EBRC X-715 Seminar Room . Contact aomari@bu.edu for more information.