Isabel Dominguez, Ph.D.
Assistant Professor of Medicine
Direct Contact: firstname.lastname@example.org
Our research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. In particular we are characterizing the molecular mechanism leading to activation of β-catenin, the key intracellular Wnt component that is upregulated in many human tumors. We are also studying the cellular and molecular mechanisms regulated by Wnt/β-catenin signaling during heart morphogenesis in mice and Xenopus laevis embryos. As we acquire a better understanding of the molecular events leading to β-catenin activation, we will be able to develop novel and specific inhibitors for the treatment of cancers with upregulated nuclear β-catenin levels, and preventing or correcting defects in morphogenetic processes that lead to congenital heart defects.
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