Isabel Dominguez

Dominguez_Isabel-2-5x3-5Assistant Professor

Education:

B.S., 1988, Universidad del Pais Vasco/Basque Country University, Bilbao, Spain

M.Sc., 1989, Biochemistry Department, Universidad del Pais Vasco/Basque Country University, Bilbao, Spain

Ph.D., 1994, Centro de Biologia Molecular/Molecular Biology Center. Universidad Autonoma de Madrid, Madrid, Spain

Postdoctoral Fellow, 1994-1996, Beth Israel Hospital & Department of Microbiology and Molecular Genetics, Harvard Medical School. Boston, USA. (Mentor: Sergei Sokol)

Postdoctoral Fellow and Research associate, 1996-2001, Dana Farber Cancer Institute & Department of Genetics, Harvard Medical School. Boston, USA. (Mentor: Jeremy B.A. Green)

General field of research:

Embryonic development, Wnt signaling, tumorigenesis

Summary of Research Interest:

Our research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. In particular we are characterizing the molecular mechanism leading to activation of β-catenin, the key intracellular Wnt component that is upregulated in many human tumors. We are also studying the cellular and molecular mechanisms regulated by Wnt/β-catenin signaling during heart morphogenesis in mice and Xenopus laevis embryos. As we acquire a better understanding of the molecular events leading to β-catenin activation, we will be able to develop novel and specific inhibitors for the treatment of cancers with upregulated nuclear β-catenin levels, and preventing or correcting defects in morphogenetic processes that lead to congenital heart defects.

For more information about Dr. Dominguez’s research work please see her laboratory website: http://sites.bu.edu/dominguezlab

Contact information:

Office
650 Albany Street X438
Phone: (617) 414 1829

Laboratory
650 Albany Street X430
Phone: (617) 638 7560
Fax: (617) 638 7530
isdoming@bu.edu

Administrative and Teaching Appointments:

MAMS student advisor (http://www.bumc.bu.edu/gms/gateway/prospective/masters-in-medical-sciences/)

Assistant Director Medical Student Summer Research Program (MSSRP) (http://www.bumc.bu.edu/enrichment/research/)

Co-Director of the Basic Medical Sciences course (PS701) in the PA Program. (http://www.bu.edu/paprogram/)

Other Affiliations:

Co-Chair, DOM Faculty Development and Diversity Committee

Faculty advisor for MISO (Minority and International Scientists Organization)

Affiliations other than medicine:

Co-Chair, DOM Faculty Development and Diversity Committee

Faculty advisor for MISO (Minority and International Scientists Organization)

Department of Medicine, Section of Hematology/Oncology

Cancer Center

Women’s Health Interdisciplinary Research Center

Developmental Biology Research Group (DBRG)

Evans Center for Interdisciplinary Biomedical Research

BUMC Genome Science Institute

Center for Regenerative Medicine (CReM)

Molecular Medicine Graduate Program

Biomolecular Pharmacology Graduate Program

Other affiliations:

Founder and Member of the Board of Directors of ECUSA-Boston

Member Board of Board of Directors of ECUSA-USA

Program Coordinator of the Spanish Cultural Association of Boston (ACE)

Other research websites:

http://www.bumc.bu.edu/hematology/research-activities/m-isabel-dominguez-phd-2/

Keywords:

Wnt signaling; CK2; beta-catenin; Heart Development; Xenopus laevis; Breast Cancer

Technologies available for sharing upon request:

Xenopus laevis bioassays; immunoblotting; immunohistochemistry; real-time PCR; in situ hybridization.