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DENIS LABORATORY — KEY PUBLICATIONS
1. Bromodomain protein Brd2-driven B cell malignancy in a mouse model.
Greenwald R., J. R. Tumang, A. Sinha, N. Currier, R. D. Cardiff, T. L. Rothstein, D. V. Faller and G. V. Denis (2004). E(mu)-BRD2 transgenic mice develop B cell lymphoma and leukemia. Blood 103: 1475 – 1484.
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2. Bromodomain analysis of cyclin A transcription.
Sinha, A., D. V. Faller and G. V. Denis (2005). Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem. J. 387: 257 – 269.
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3. MALDI and LC-MS/MS identification of Brd2 multiprotein complexes.
Denis, G. V., M. E. McComb, D. V. Faller, A. Sinha, P. B. Romesser and C. E. Costello (2006). Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J. Proteome Res. 5: 502 – 511.
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4. Genome-wide transcriptional and proteomic profiling reveal a malignancy signature of diffuse large B cell lymphoma.
Lenburg, M., A. Sinha, D. V. Faller and G. V. Denis (2007). Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J. Biol. Chem. 282: 4803 – 4811.
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Romesser, P. B., D. H. Perlman, D. V. Faller, C. E. Costello, M. E. McComb and G. V. Denis (2009). Development of a malignancy-associated proteomic signature for diffuse large B cell lymphoma. Am. J. Pathol. 175: in press. Online publication 4 June 2009. PMID in progress.
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5. Therapeutics for leukemia and lymphoma.
Denis, G. V. (2007). Imatinib mesylate (Gleevec) and the emergence of chemotherapeutic drug-resistant mutations. In H. L. Kaufman, S. Wadler and K. H. Antman, Eds., Cancer Drug Discovery and Development; Specific Drugs for Molecular Targeting in Oncology,, Part IV, Chapter 22. Humana Press; Totowa, NJ. In press.
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Longe, H., P. B. Romesser, A. Rankin, D. V. Faller, M. S. Eller, B. A. Gilchrest and G. V. Denis (2009). Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential. Int. J. Cancer. 124:473–482.
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