Lindsay A. Farrer, Ph.D.

Lindsay A. Farrer, Ph.D.
Chief, Biomedical Genetics
BU Distinguished Professor of Genetics Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics
Director, Boston University Molecular Genetics Core Facility
Director, Boston University Transformative Training Program in Addiction Science
Phone: (617) 358-3550
Fax: (617) 358-3551
Email: farrer@bu.edu
Location: BU Medical School, E250


Education:
1981 B.A. University of North Carolina (Population Genetics)
1985 Ph.D. Indiana University School of Medicine (Medical Genetics)

Postdoctoral Training:
1985-1987 NIH Postdoctoral Fellow, Department of Human Genetics, Yale University School of Medicine

Appointments:
1987-1992 Assistant Professor of Neurology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
1987-present  Instructor in Neurology, Harvard University School of Medicine
1992-1997 Associate Professor of Neurology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
1997-present  Professor of Neurology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health
1998-present  Professor of Medicine and Chief, Biomedical Genetics Section, BUSM
1998-present  Director, Boston University Molecular Genetics Core Facility
2000-2003 Scientific Advisory Board, Sequenom, Inc. (San Diego, CA)
2002-2008 Professor of Genetics & Genomics, BUSM
2010-present Professor of Ophthalmology, BUSM
2012-present  Director, Boston University Transformative Training Program in Addiction Science
2015-present  Boston University Distinguished Professor of Genetics, BUSM

Awards and Honors:
1981-1982 Indiana University-Purdue University at Indianapolis Fellowship
1984 Graduate Student Competition for Sigma Xi, second place
1984-1985 John H. Edwards Fellowship
1985-1987 NIH Postdoctoral Training Fellowship
1987 Postdoctoral National Research Service Award – declined
1991-1993 Alfred P. Sloan Research Fellow
1997 Who’s Who in America (1998 edition)
1997 Who’s Who in Medicine and Health Care (1999-2000 edition)
1998 Who’s Who in the World (1999 edition)
1999 Who is Who in Science and Engineering (1999 edition)
2000 Joseph M. Foley Lecturer (Case Western University)
2002 Distinguished Alumnus Award – Department of Medical & Molecular Genetics, Indiana University School of Medicine
2011 Distinguished Scientist Award -Department of Medicine, Boston University School of Medicine
2015 Jack Spivack Excellence in Neuroscience Research Award
2015 Boston University Distinguished Professor of Genetics
2019 BU Evans Center for Interdisciplinary Biomedical Research Leadership Award

Selected Publications

1. Cox J, Sherva R, Lunetta KL, Saitz R, Kon M, Kranzler HR, Gelernter J, Farrer LA. Identifying factors associated with opioid cessation in a biracial sample using machine learning. Explor Med 2020; 1:27-41. https://doi.org/10.37349/emed.2020.00003

2. Cox JW, Sherva RM, Lunetta KL, Johnson EC, Martin NG, Degenhardt L, Agrawal A, Nelson EC, Kranzler H, Gelernter J, Farrer LA. Genome-wide association study of opioid cessation. J Clin Med 2020; 9:180. PMID: 31936517 https://www.mdpi.com/2077-0383/9/1/180

3. Ma Y, Zhang X, Jun G, Chung J, Naj AC, Belinguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Alzheimer Disease Sequencing Project, ADES-FR, Bis JC, DeStefano AL, Fornage M, van Duijn C, Bennett D, DeJager P, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert J-C, Schellenberg GD, Lunetta KL, Farrer LA. Novel Alzheimer disease loci identified in subsets of whole exome sequencing data stratified by APOE genotype. JAMA Neurol 2020. In press. PMID: 31180460 https://jamanetwork.com/journals/jamaneurology/fullarticle/2735123

4. Handa, JT, Bowes Rickman C, DickAD, Gorin MB, Miller JW, Toth CA, Ueffing M, Zarbin M, Farrer LA. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nat Commun 2019; 10:3347. PMID: 31350409 https://www.nature.com/articles/s41467-019-11262-1

5. Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J, Alzheimer’s Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA. A rare missense variant in CASP7 is associated with familial late-onset Alzheimer disease. Alzheimer Dement 2019; 15:441-452. PMID: 30503768 https://www.sciencedirect.com/science/article/pii/S1552526018335799?via%3Dihub

6. Chung J, Jun GR, Dupuis J, Farrer LA. Comparison of methods for multivariate gene-based association tests using common variants for complex disease. Eur J Hum Genet 2019; 27:811-823. PMID: 30683923 https://www.nature.com/articles/s41431-018-0327-8

7. Patel D, Mez J, Vardarajan B, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Alzheimer Disease Sequencing Project, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Network Open 2019; 2(3):e191350. PMID: 30924900 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2729478

8. Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton KL, Bush WS, Salerno W, Lancour D, Ma Y, Renton AE, Marcora EM, Farrell J, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues J-F, Debette S, Deleuze J-F, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havulinna AS, Helisalmi S, Hiltunen M, Howrigan DP, Ikram MA, Kaprio J, Konrad J, Kuzma A, Lander ES, Lathrop M, Lehtimäki T, Lin H, Mattila K, Mayeux R, Muzny DM, Nasser W, Neale B, Nho K, Nicolas G, Patel D, Pericak-Vance M, Perola M, Psaty BM, Quenez O, Rajabli F, Redon R, Reitz C, Remes A, Salomaa V, Sarnowski C, Schmidt H, Schmidt M, Schmidt R, Soininen H, Thornton T, Tosto G, Tzourio C, van der Lee SJ, van Duijn CM, Vardarajan BN, Wang W, Wijsman E, Wilson RK, Witten D, Worley K, Zhang X, Alzheimer’s Disease Sequencing Project, Bellenguez C, Lambert J-C, Kurki M, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj AC, Fornage M, Farrer LA. Whole exome sequencing study identifies novel rare and common Alzheimer’s-associated variants involved in immune response and transcriptional regulation. Mol Psychiatry 2019. In press. PMID: 30108311 https://www.nature.com/articles/s41380-018-0112-7 

9. Lancour D, Naj A, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GC, Crovella M, Farrer LA, Kasif S. One for all and all for one: improving replication of genetic studies through network diffusion. PLoS Genet 2018; 14(4):e1007306. PMID: 29684019 http://www.journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007306

10. Jaeyoon Chung, Xiaoling Zhang, Mariet Allen, Xue Wang, Yiyi Ma, Gary Beecham, Thomas J. Montine, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilufer Ertekin-Taner, Kathryn L. Lunetta, Jesse Mez, Alzheimer Disease Genetics Consortium, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard Schellenberg, Gyungah Jun, Lindsay A. Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer disease. Alzheimers Res Ther 2018;10:22. PMID:29458411 https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0349-z

11.  Jaeyoon Chung, Xulong Wang, Toru Maruyama, Yiyi Ma, Xiaoling Zhang, Jesse Mez, Richard Sherva, Haruko Takeyama, The Alzheimer’s Disease Neuroimaging Initiative, Kathryn L. Lunetta , Lindsay A. Farrer, Gyungah Jun. Genome-wide association study of Alzheimer’s disease endophenotypes at prediagnosis stages. Alzheimer’s & Dementia 2018; 14:623-633. In press. PMID: 29274321 http://www.sciencedirect.com/science/article/pii/S1552526017338426

12. Tsuneya Ikezu, Cidi Chen, Annina M. DeLeo, Ella Zeldich, M. Daniele Fallin, Nicholas M. Kanaan, Kathryn L. Lunetta, Carmela R. Abraham, Mark W. Logue, Lindsay A. Farrer. Tau phosphorylation is impacted by rare AKAP9 mutations associated with Alzheimer disease in African Americans. Neuroimmune Pharm 2018; 13: 254-264. In press. PMID: 29516269 https://link.springer.com/article/10.1007%2Fs11481-018-9781-x

13.  Renato Polimanti, Qian Wang, Shashwath A. Meda, Krishna T. Patel, Godfrey D. Pearlson, Hongyu Zhao, Lindsay A. Farrer, Henry R. Kranzler & Joel Gelernter. The interplay between risky sexual behaviors and alcohol dependence: genome-wide association and neuroimaging support for LHPP as a risk gene. Neuropsychopharmacology 2017; 42:598-605. PMID: 27531626 http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2016153a.html

14. Qian Wang, Renato Polimanti, Henry R. Kranzler HR, Lindsay A. Farrer, Hongyu Zhao, Joel Gelernter. Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: Antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Human Genetics 2017; 136:75-83. PMID:27752767 http://link.springer.com/article/10.1007%2Fs00439-016- 1737-8

15. Elisha M. Wachman MD, Marie J. Hayes PhD, Richard Sherva PhD, Mark S. Brown MD, Hira Shrestha MA, Beth A. Logan, Nicole A. Heller PhD, David A. Nielsen PhD, Lindsay A. Farrer PhD. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Am J Addict 2017; 26:42-49. PMID: 27983768 http://onlinelibrary.wiley.com/doi/10.1111/ajad.12483/abstract

16. KP Jensen, AH Smith, AI Herman, LA Farrer, HR Kranzler, M Sofuoglu and J Gelernter J. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Mol Psychiatry 2017; 22:242-249. PMID:27067016 http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp201643a.pdf

17. Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry 2017; 22:346-352. PMID: 28115739 https://www.ncbi.nlm.nih.gov/pubmed/28115739

18. Gyungah R. Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W. Beecham, David A. Bennett, Joseph D. Buxbaum, Goldie S. Byrd, Minerva M. Carasquillo M, Paul K. Crane, Carlos Cruchaga, Philip De Jager P, Nilufer Ertekin-Taner, Denis Evans, M. Danielle Fallin, Tatiana M. Foroud, Robert P. Friedland, Alison M. Goate, Neil R. Graff-Radford, Hugh Hendrie, Kathleen S. Hall, Kara L. Hamilton-Nelson, Rivka Inzelberg, M. Ilyas Kamboh, John S.K. Kauwe, Walter A. Kukull, Brian W. Kunkle, Ryozo Kuwano, Eric B. Larson, Mark W. Logue, Jennifer J. Manly, Eden R. Martin, Thomas J. Montine, Shubhabrata Mukherjee, Adam Naj, Eric M. Reiman, Christiane Reitz, Richard Sherva, Peter H. St. George-Hyslop PH, Timothy Thornton, Steven Younkin, Badri N. Vardarajan, Li-San Wang, Jens R. Wendlund, Ashely R. Winslow, Alzheimer Disease Genetics Consortium, Perrie M. Adams, Marilyn S. Albert… Lindsay A. Farrer. Transethnic Genome-Wide Scan Identifies Novel Alzheimer Disease Loci. Alzheimers Dement 2017. In press. PMID: 28183528. http://www.sciencedirect.com/science/article/pii/S1552526017300031

19. Polimanti R, Meda SW, Pearlson GD, Sherva R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene-by-cannabis dependence interaction analysis of risky sexual behaviors. J Psych Neurosci. 2017; 13;42:160189. PMID: 28418321. http://jpn.ca/wpcontent/uploads/2017/04/42-4-160189.pdf

20. Huang K, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax B, Czajkowski J, Chouraki V, Grenier¬Boley B, Bellenguez C, Deming Y, McKenzie A, Raj T, Renton AE, Budde J, Smith A, Fitzpatrick A, Bis JC, DeStefano A, Adams HHH, Ikram MA, van der Lee S, Del-Aguila JL, Fernandez MV, Ibanez L, The International Genomics of Alzheimer’s Project, The Alzheimer’s Disease Neuroimaging Initiative, Sims R, Escott-Price, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Lambert JC, van Duijn C, Launer L, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Zhang B, Borecki I, Kauwe JSK, Cruchaga C, Hao K, Goate. A common haplotype lowers PU.1 expression in myeloid cells and delays age at onset of Alzheimer’s disease. Nature Neurosci 2017. In press.

21. Jun G, Ibrahim-Verbaas CA, Vronskaya M,.. .112 authors…, van Duijn CM Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psych 2016; 21:108-117. PMID: 25778476 [pubmed]

22. Brian W. Kunkle, James Jaworski, Sandra Barral, Badri Vardarajan, Gary W. Beecham, Eden R. Martin, Laura S. Cantwell, Amanda Partch, Thomas D. Bird, Wendy H. Raskind, Anita L. DeStefano, Regina M. Carney, Michael Cuccaro, Jeffrey M. Vance, Lindsay A. Farrer, Alison M. Goate, Tatiana Foroud, Richard P. Mayeux, Gerard D. Schellenberg, Jonathan L. Haines, Margaret A. Pericak-Vance. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer’s disease. Alzheimer’s & Dementia 2016; 12:2-10. PMID: 26365416. http://www.sciencedirect.com/science/article/pii/S1552526015002241