Lindsay A Farrer, Ph.D.

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Lindsay A. Farrer, Ph.D.

Chief, Biomedical Genetics
BU Distinguished Professor of Genetics Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics

 

 

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Education:
1981 B.A. University of North Carolina (Population Genetics)
1985 Ph.D. Indiana University School of Medicine (Medical Genetics) Postdoctoral Training: 1985-1987 NIH Postdoctoral Fellow, Department of Human Genetics, Yale University School of Medicine

Postdoctoral Training:
1985-1987 NIH Postdoctoral Fellow, Department of Human Genetics, Yale University School of Medicine

Awards and Honors:
1981-1982 Indiana University-Purdue University at Indianapolis Fellowship
1984 Graduate Student Competition for Sigma Xi, second place
1984-1985 John H. Edwards Fellowship
1985-1987 NIH Postdoctoral Training Fellowship
1987 Postdoctoral National Research Service Award – declined
1991-1993 Alfred P. Sloan Research Fellow
1997 Who’s Who in America (1998 edition)
1997 Who’s Who in Medicine and Health Care (1999-2000 edition)
1998 Who’s Who in the World (1999 edition)
1999 Who is Who in Science and Engineering (1999 edition)
2000 Joseph M. Foley Lecturer (Case Western University)
2002 Distinguished Alumnus Award – Department of Medical & Molecular Genetics, Indiana University School of Medicine
2011 Distinguished Scientist Award -Department of Medicine, Boston University School of Medicine
2015 Jack Spivack Excellence in Neuroscience Research Award
2015 Boston University Distinguished Professor of Genetics

Selected Publications

1. Jaeyoon Chung, Xiaoling Zhang, Mariet Allen, Xue Wang, Yiyi Ma, Gary Beecham, Thomas J. Montine, Steven G. Younkin, Dennis W. Dickson, Todd E. Golde, Nathan D. Price, Nilufer Ertekin-Taner, Kathryn L. Lunetta, Jesse Mez, Alzheimer Disease Genetics Consortium, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard Schellenberg, Gyungah Jun, Lindsay A. Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer disease. Alzheimers Res Ther 2018;10:22. PMID:29458411 https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0349-z

2.  Jaeyoon Chung, Xulong Wang, Toru Maruyama, Yiyi Ma, Xiaoling Zhang, Jesse Mez, Richard Sherva, Haruko Takeyama, The Alzheimer’s Disease Neuroimaging Initiative, Kathryn L. Lunetta , Lindsay A. Farrer, Gyungah Jun. Genome-wide association study of Alzheimer’s disease endophenotypes at prediagnosis stages. Alzheimer’s & Dementia 2018. In press. PMID: 29274321 http://www.sciencedirect.com/science/article/pii/S1552526017338426

3. Tsuneya Ikezu, Cidi Chen, Annina M. DeLeo, Ella Zeldich, M. Daniele Fallin, Nicholas M. Kanaan, Kathryn L. Lunetta, Carmela R. Abraham, Mark W. Logue, Lindsay A. Farrer. Tau phosphorylation is impacted by rare AKAP9 mutations associated with Alzheimer disease in African Americans. Neuroimmune Pharm 2018. In press. PMID: 29516269 https://link.springer.com/article/10.1007%2Fs11481-018-9781-x

4.  Renato Polimanti, Qian Wang, Shashwath A. Meda, Krishna T. Patel, Godfrey D. Pearlson, Hongyu Zhao, Lindsay A. Farrer, Henry R. Kranzler & Joel Gelernter. The interplay between risky sexual behaviors and alcohol dependence: genome-wide association and neuroimaging support for LHPP as a risk gene. Neuropsychopharmacology 2017; 42:598-605. PMID: 27531626 http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2016153a.html

5. Qian Wang, Renato Polimanti, Henry R. Kranzler HR, Lindsay A. Farrer, Hongyu Zhao, Joel Gelernter. Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: Antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Human Genetics 2017; 136:75-83. PMID:27752767 http://link.springer.com/article/10.1007%2Fs00439-016- 1737-8

6. Elisha M. Wachman MD, Marie J. Hayes PhD, Richard Sherva PhD, Mark S. Brown MD, Hira Shrestha MA, Beth A. Logan, Nicole A. Heller PhD, David A. Nielsen PhD, Lindsay A. Farrer PhD. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Am J Addict 2017; 26:42-49. PMID: 27983768 http://onlinelibrary.wiley.com/doi/10.1111/ajad.12483/abstract

7. KP Jensen, AH Smith, AI Herman, LA Farrer, HR Kranzler, M Sofuoglu and J Gelernter J. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Mol Psychiatry 2017; 22:242-249. PMID:27067016 http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp201643a.pdf

8. Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry 2017; 22:346-352. PMID: 28115739 https://www.ncbi.nlm.nih.gov/pubmed/28115739

9. Gyungah R. Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W. Beecham, David A. Bennett, Joseph D. Buxbaum, Goldie S. Byrd, Minerva M. Carasquillo M, Paul K. Crane, Carlos Cruchaga, Philip De Jager P, Nilufer Ertekin-Taner, Denis Evans, M. Danielle Fallin, Tatiana M. Foroud, Robert P. Friedland, Alison M. Goate, Neil R. Graff-Radford, Hugh Hendrie, Kathleen S. Hall, Kara L. Hamilton-Nelson, Rivka Inzelberg, M. Ilyas Kamboh, John S.K. Kauwe, Walter A. Kukull, Brian W. Kunkle, Ryozo Kuwano, Eric B. Larson, Mark W. Logue, Jennifer J. Manly, Eden R. Martin, Thomas J. Montine, Shubhabrata Mukherjee, Adam Naj, Eric M. Reiman, Christiane Reitz, Richard Sherva, Peter H. St. George-Hyslop PH, Timothy Thornton, Steven Younkin, Badri N. Vardarajan, Li-San Wang, Jens R. Wendlund, Ashely R. Winslow, Alzheimer Disease Genetics Consortium, Perrie M. Adams, Marilyn S. Albert… Lindsay A. Farrer. Transethnic Genome-Wide Scan Identifies Novel Alzheimer Disease Loci. Alzheimers Dement 2017. In press. PMID: 28183528. http://www.sciencedirect.com/science/article/pii/S1552526017300031

10. Polimanti R, Meda SW, Pearlson GD, Sherva R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene-by-cannabis dependence interaction analysis of risky sexual behaviors. J Psych Neurosci. 2017; 13;42:160189. PMID: 28418321. http://jpn.ca/wpcontent/uploads/2017/04/42-4-160189.pdf

11. Huang K, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax B, Czajkowski J, Chouraki V, Grenier¬Boley B, Bellenguez C, Deming Y, McKenzie A, Raj T, Renton AE, Budde J, Smith A, Fitzpatrick A, Bis JC, DeStefano A, Adams HHH, Ikram MA, van der Lee S, Del-Aguila JL, Fernandez MV, Ibanez L, The International Genomics of Alzheimer’s Project, The Alzheimer’s Disease Neuroimaging Initiative, Sims R, Escott-Price, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Lambert JC, van Duijn C, Launer L, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Zhang B, Borecki I, Kauwe JSK, Cruchaga C, Hao K, Goate. A common haplotype lowers PU.1 expression in myeloid cells and delays age at onset of Alzheimer’s disease. Nature Neurosci 2017. In press.

12. Jun G, Ibrahim-Verbaas CA, Vronskaya M,.. .112 authors…, van Duijn CM Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psych 2016; 21:108-117. PMID: 25778476 [pubmed]

13. Brian W. Kunkle, James Jaworski, Sandra Barral, Badri Vardarajan, Gary W. Beecham, Eden R. Martin, Laura S. Cantwell, Amanda Partch, Thomas D. Bird, Wendy H. Raskind, Anita L. DeStefano, Regina M. Carney, Michael Cuccaro, Jeffrey M. Vance, Lindsay A. Farrer, Alison M. Goate, Tatiana Foroud, Richard P. Mayeux, Gerard D. Schellenberg, Jonathan L. Haines, Margaret A. Pericak-Vance. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer’s disease. Alzheimer’s & Dementia 2016; 12:2-10. PMID: 26365416. http://www.sciencedirect.com/science/article/pii/S1552526015002241