Deborah A. Siwik, PhD
Deborah A. Siwik, Ph.D.
Research Assistant Professor
Myocardial Biology, X747
Boston University Medical Center
650 Albany Street
Boston, MA 02118
Phone: (617) 638-8022
Fax: (617) 638-8081
email: dasiwik@bu.edu
Deborah A. Siwik, Ph.D., is a Prinicipal Investigator in the Whitaker Cardiovascular Institute, and the Lab Director of the Myocardial Biology Unit. She received her Ph.D. in Pharmacology from the University of Illinois at Chicago and her post-doctoral training at Brigham and Women’s Hospital and Harvard Medical School and at Boston University.
Dr. Siwik is currently investigating the regulation of the myocardial extracellular matrix and the effects of oxidative stress on the myocardium. A major focus is to understand the roles of nitric oxide, oxidative stress, and inflammatory cytokines in mediating changes in extracellular matrix.
As part of the Cardiovascular Proteomics Center, the lab is identifying chemical modifications of proteins formed by reactive oxygen, nitrogen, and lipid species that may contribute to pathology and serve as better markers for disease severity.
Dr. Siwik regularly accepts students for training. More information can be found at the Boston University Undergraduate Research Opportunities Program web site.
EMMPRIN Mediates Beta-Adrenergic Receptor-Stimulated Matrix Metalloproteinase Activity in Cardiac Myocytes. Siwik DA, Kuster GM, Brahmbhatt JV, Zaidi Z, Malik J, Ooi H, Ghorayeb G, 2008. J Mol Cell Cardiol 44(1)210-217.
Relations of Matrix Remodeling Biomarkers to Blood Pressure Progression and Incidence of Hypertension in the Community. Dhingra R, Pencina MJ, Schrader P, Wang TJ, Levy D, Meigs J, Pencina K, Sundstrom J, Siwik DA, Colucci WS, Benjamin EJ, Vasan RS, 2009. Circulation 119(8):1101-1107.
Nitroxyl Anion Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674. Lancel S, Zhang J, Evangelista A, Trucillo MP, Siwik DA, Cohen RA, Colucci WS, 2009. Circ Res 104(6):720-723.
Enhanced exercise capacity in mice with severe heart failure treated with a novel allosteric effector of hemoglobin, ITPP. Biolo A, Greferath R, Siwik DA, Qin F, Valsky E, Fylaktakidou KC, Pothukanuri S, Duarte CD, Schwartz RP, Lehn J-M, Nicolau C, Colucci WS, 2009. Proc Natl Acad Sci USA 106(6):1926-1929.
Links:
Link to Whitaker Cardiovascular Institute Homepage
