Deborah A. Siwik, PhD
Research Assistant Professor
Myocardial Biology, X747
Boston University Medical Center
650 Albany Street
Boston, MA 02118
Phone: (617) 638-8022
Fax: (617) 638-8081
Deborah A. Siwik, Ph.D., is a Prinicipal Investigator in the Whitaker Cardiovascular Institute, and the Lab Director of the Myocardial Biology Unit. She received her Ph.D. in Pharmacology from the University of Illinois at Chicago and her post-doctoral training at Brigham and Women’s Hospital and Harvard Medical School and at Boston University.
Dr. Siwik is currently investigating the regulation of the myocardial extracellular matrix and the effects of oxidative stress on the myocardium. A major focus is to understand the roles of nitric oxide, oxidative stress, and inflammatory cytokines in mediating changes in extracellular matrix.
As part of the Cardiovascular Proteomics Center, the lab is identifying chemical modifications of proteins formed by reactive oxygen, nitrogen, and lipid species that may contribute to pathology and serve as better markers for disease severity.
Relations of Matrix Remodeling Biomarkers to Blood Pressure Progression and Incidence of Hypertension in the Community. Dhingra R, Pencina MJ, Schrader P, Wang TJ, Levy D, Meigs J, Pencina K, Sundstrom J, Siwik DA, Colucci WS, Benjamin EJ, Vasan RS, 2009. Circulation 119(8):1101-1107.
Enhanced exercise capacity in mice with severe heart failure treated with a novel allosteric effector of hemoglobin, ITPP. Biolo A, Greferath R, Siwik DA, Qin F, Valsky E, Fylaktakidou KC, Pothukanuri S, Duarte CD, Schwartz RP, Lehn J-M, Nicolau C, Colucci WS, 2009. Proc Natl Acad Sci USA 106(6):1926-1929.
Link to Whitaker Cardiovascular Institute Homepage