BUPID Top-Down

BUPID Top-Down: Software Tools for Analysis of Top-Down MS/MS Spectra – Coming Soon!

BUPID (Boston University Protein Identifier) Top-Down is a web-based platform developed at the Cardiovascular Proteomics Center of Boston University School of Medicine (Boston, MA). The platform provides the means to analyze top-down MS/MS spectra obtained with a number of fragmentation methods, including CID, ECD, and ETD. Several software tools are available and may be used in any combination.

Tools Available

  • Deconvolution
  • Protein identification
  • Fragment ion assignment
  • Sequence variant analysis
  • Mass shift analysis

Input Requirements

  • Deconvoluted peak list or, for raw data, mzML or mzXML files without compression
  • Additional information depending on selected tools

Output

  • Raw results in YAML format
  • Built-in visualization tools
  • Convenient download for further analysis (manual; other software)

Disclaimer

BUPID Top-Down was developed at the Cardiovascular Proteomics Center of Boston University School of Medicine (Boston, MA). The software tools are freely available for external testing. We assume no responsibility for their use, and we make no guarantees, whether expressed or implied, about their performance or any other characteristics. We would appreciate acknowledgment of our organization if BUPID Top-Down is used.

Publications

Conference Presentations

Primary teaching affiliate
of BU School of Medicine