The Cardiovascular Proteomics Center (CPC) Core Research Laboratory is part of the BUSM Center for Biomedical Mass Spectrometry. The CPC is one of 7 National Heart Lung and Blood Institute Proteomics Centers. The Core’s aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with markers of human disease with an emphasis directed towards cardiovascular disease. The laboratory focuses on applying mass spectrometry-based proteomics technology for the identification and characterization of proteins which may be perturbed by disease mechanism in-vivo. By studying these proteins and PTMs the aim is to identify patterns of changes and PTM events in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility.