Introduction to Medical Pharmacology


Introduction to Medical Pharmacology, GMS PM 730

Prereq: Premedical curriculum.

Walsh, staff. 4 cr, 2nd sem.


Objectives, Assignments, and Grading

Course Objectives: This course is designed to introduce medical pharmacology to students who are pursuing degrees in the Medical Sciences. Topics will include the basic principles of pharmacology and several major classes of therapeutic agents, with attention to their mechanisms of action. Issues of current and future concern in medical pharmacology will be addressed including the sources of information about pharmacologic agents, the ethics of human experimentation, the drug development process and its costs, problems of drug abuse, and new biotechnological approaches to drug design.

Reading Assignments: The text for this course is Levine’s Pharmacology: Drug Actions and Reactions, 7th ed., Carol T. Walsh and Rochelle Schwartz-Bloom, Taylor & Francis, 2005. The book is available through e-Book resources in the library. The reading assignments for each class are indicated on the lecture schedule. Other reading assignments may be distributed in class or on the CourseInfo site.

Course Grade: The course grade will be determined from the grades for the writing assignment (20%) and the two examinations (40% each). The numerical paper grade times 0.2 plus each exam score times 0.4 will be summed. This final score will be converted to a letter grade as follows: 94 and above, A; 90-93, A-; 87-89, B+; 84-86, B; 80-83, B-; 77-79, C+; 74-76, C; 70-73, C-; 60-69, D; less than 60, F.

Course Manager: Carol T. Walsh, Ph.D. – R-610, 638-4326, ctwalsh@bu.edu


Lecture Schedule

Semester 2, 2014-2015
Mondays and Wednesdays, 10:00-11:50 AM
Lectures in L-110
DATE – TOPIC – LECTURER

Jan 21- Introduction and Development of Pharmacology – Carol Walsh

Jan 26 – Mechanisms of Drug Actions – Carol Walsh

Jan 28 – Drug Transport and Absorption – Carol Walsh

Feb 2 – Drug Distribution and Elimination – Carol Walsh

Feb 4 – Time-Concentration Relationships – Carol Walsh

Feb 9 – Biopharmaceutics, Drug Delivery Systems, and Generic vs. Proprietary
Drugs (video) – Carol Walsh

Feb 11 – Principles of Pharmacodynamics – Pietro Cottone

Feb 18 – Population Pharmacology 1: Phenotype, Genotype and the Placebo Response, PK Pretest Discussion – Carol Walsh

Feb 23 – Pharmacology of the Autonomic Nervous System – Richard Wainford

Feb 25 – Pharmacology of Hypertension – Richard Wainford

Mar 2 – Population Pharmacology 2: Adherence, Interactions, the Allergic Response, and Mechanisms of Tolerance – Carol Walsh

Mar 4 – Ethical Issues in the Clinical Study of Drugs – Leonard Glantz

Mar 16 – Sources of Information about Drugs – Carol Walsh, David Flynn

Mar 18 – Mid-Term Examination

Mar 23 – Principles of Toxicology – Carol Walsh

Mar 25 – Incidence and Treatment of Poisonings – Sophie Dyer and Carol Walsh

Mar 30 – Pharmacology of Pain and Inflammation – Carol Walsh

Apr 1 – Pharmacology of Parkinson’s Disease – Benjamin Wolozin

Apr 6 – Pharmacology of Substance Abuse and of Pharmacology of CNS Stimulants: Cocaine, Amphetamines, Caffeine, and Nicotine – Pietro Cottona, Valentina Sabino

Apr 8 – Development and Pharmacology of Antianxiety and Antiepileptic Agents – Shelley Russek

Apr 13 – Principles of Chemotherapy – Carol Walsh

Apr 15 – Advances in Drug Development: Neurosteroids and Treatment of Stroke – David Farb

Apr 22 – Advances in Drug Development: Biopharmaceuticals – Jas Seehra

Apr 27 – The Drug Development Process – Barry Berkowitz

Apr 29 – Economic Aspects of Drug Development and Drug Use – Joseph DiMasi and Paul Jeffrey

May 6 – Final Examination


Lecturers

BERKOWITZ, Barry, Ph.D., Adjunct Professor of Pharmacology. Formerly President and CEO, Scion Pharmaceuticals. Research interest: Drug development. 508-877-4522, 508-982-0509, strongpharma@gmail.com

COTTONE, Pietro, Ph.D., Associate Professor of Pharmacology and Psychiatry. Research interest: Neurobiology of addictions including eating disorders. R-618, Ext. 8-5662, cottone@bu.edu.

DIMASI, Joseph, Ph.D., Center for the Study of Drug Development, Tufts University, 192 South St. Suite 550, Boston, 02111.  Research interest:  Economic aspects of drug development. 636-2116 or 636-2170, Joseph.DiMasi@tufts.edu

DYER, Sophia, M.D., Associate Professor of Emergency Medicine, Dowling G06, 617-343-1125, dyer@bostonems.org

FARB, David H., Ph.D., Professor and Chairman of Pharmacology.  Research interest:  Neurosteroids and their effects on CNS receptors.  L-603, Ext. 8-4300, dfarb@bu.edu

FLYNN, David, Head of Library and Information Management Education, BUSM Alumni Library, 8-4271, dflynn@bu.edu

GLANTZ, Leonard, J.D., Professor of Public Health.  Research interest:  Medical ethics and health law. A4, Ext. 8-4640, lglantz@bu.edu

JEFFREY, Paul L., Pharm.D., Former Director of the Pharmacy, Boston Medical Center. Pharmacy Consultant, Massachusetts Division of Medical Assistance, Office of Clinical Affairs, 617-847-3732, paul.jeffrey@state.ma.us. Assistant, Nancy McDonald, nancy.mcdonald@state.ma.us, 617-847-3749

RUSSEK, Shelley, Ph.D., Professor of Pharmacology.  Research interest:  Regulation of genes for CNS receptors.  L-606, Ext. 8-4319, srussek@bu.edu

SABINO, Valentina, Ph.D., Assistant Professor of Pharmacology and Psychiatry. Research interest: Neurobiology of addiction and stress-related disorders. R-612, Ext. 8-4327, vsabino@bu.edu.

SEEHRA, Jasbir, Ph.D., Chief Scientific Officer, Ember Therapeutics, Watertown, MA, jseehra@embertx.com

WALSH, Carol T., Ph.D., Professor of Pharmacology.  Research interest:  Pharmacokinetics, gastrointestinal pharmacology, metal toxicology.  R-610, Ext. 8-4326, ctwalsh@bu.edu

WAINFORD, Richard, Ph.D., Assistant Professor of Pharmacology and Medicine.  Research interest: CNS regulation of blood pressure and renal function.  W-602, Ext. 4-2648, wainf@bu.edu

WIRTZ, Veronika, Pharm.D., Center for Global Health & Development, BUSPH, 801 Mass. Ave., Ext. 4-1440, vwirtz@bu.edu

WOLOZIN, Benjamin, M.D., Ph.D., Professor of Pharmacology and Neurology. Research interest: Pathogenesis of Parkinson’s disease and Alzheimer’s disease. R-614, bwolozin@bu.edu

STAFF

CHEREL, Christina, M.P.H., Boston University, Academic Manager, Department of Pharmacology & Experimental Therapeutics. R-606, Ext. 8-4301, pharm2@bu.edu