• Title Professor
  • Education PhD: National Institute for Medical Research, London, England
  • Office K606
  • Phone 617-638-4186
  • Area of Interest Growth and differentiation of cells, adipose tissue biology

Obesity has now reached pandemic proportions, resulting in dramatic increases in the occurrence of its associated disorders including diabetes and cardiovascular disease. Understanding the processes and metabolic perturbations that contribute to the expansion of adipose depots accompanying obesity is critical for the development of appropriate therapeutics. Expansion of white adipose (WAT) tissue depots particularly the intra-abdominal depots contribute to insulin resistance and inflammation that lead to type 2 diabetes, whereas brown adipose (BAT) resists expansion because it oxidizes lipids and, consequently, it is associated with an healthier phenotype.  Our studies are focused on identifying the mechanisms regulating the formation and function of white and brown adipocytes (fat cells) using a variety of experimental approaches including overexpression and knock down of specific nuclear factors that we consider to be likely regulators of these processes in cells in culture as well as in mice. At present our focus is on nuclear factors that modulate the activity of the two principal regulators of adipogenesis (fat cell differentiation) peroxisome proliferator-activated receptor gamma (PPARg) and CCAAT/enhancer binding proteins alpha, beta and delta (C/EBPs). We are particularly interested in identifying the factors regulating commitment of mesenchymal progenitors to the adipogenic lineage and are adopting a variety of approaches to achieve this goal, which includes gene profiling to discover novel regulators as well as investigating the role of selected candidate genes.

Chandru Gurunanthan – Postdoctoral Associate
Chendi Li – Postdoctoral Associate
Jean Lin – Postdoctoral Associate
Hong Wang – Postdoctoral Associate
Nabil Rabhi – Postdoctoral Associate
Jessica Jones – Graduate Student
Xinyi Liu – Visiting Researcher

  1. Lin JZ, Farmer SR. Morphogenetics in brown, beige and white fat development. Adipocyte. 2016 Apr-Jun; 5(2):130-5. PMID: 27386157.
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  2. Beluzi M, Peres SB, Henriques FS, Sertié RA, Franco FO, Santos KB, Knobl P, Andreotti S, Shida CS, Neves RX, Farmer SR, Seelaender M, Lima FB, Batista ML. Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect. PLoS One. 2015; 10(3):e0122660. PMID: 25807446.
    View in: PubMed
  3. McDonald ME, Li C, Bian H, Smith BD, Layne MD, Farmer SR. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell. 2015 Jan 15; 160(1-2):105-18. PMID: 25579684.
    View in: PubMed
  4. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629.
    View in: PubMed
  5. Batista ML, Neves RX, Peres SB, Yamashita AS, Shida CS, Farmer SR, Seelaender M. Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol. 2012 Dec; 215(3):363-73. PMID: 23033362.
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  6. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppar?. Cell. 2012 Aug 3; 150(3):620-32. PMID: 22863012.
    View in: PubMed
  7. Pino E, Wang H, McDonald ME, Qiang L, Farmer SR. Roles for peroxisome proliferator-activated receptor ? (PPAR?) and PPAR? coactivators 1a and 1ß in regulating response of white and brown adipocytes to hypoxia. J Biol Chem. 2012 May 25; 287(22):18351-8. PMID: 22493496.
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  8. Boss O, Farmer SR. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne). 2012; 3:14. PMID: 22654854.
    View in: PubMed
  9. Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011; 6(11):e28146. PMID: 22140527.
    View in: PubMed
  10. Batista ML, Peres SB, McDonald ME, Alcantara PS, Olivan M, Otoch JP, Farmer SR, Seelaender M. Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors. Cytokine. 2012 Jan; 57(1):9-16. PMID: 22099872.
    View in: PubMed

Complete list can be found at BU Profiles

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