• Title Research Associate Professor
  • Education B. Sc. Peking University, Beijing, China
    Ph. D. Cornell University, Ithaca, NY
  • Office 670 Albany St. 5th Floor
  • Phone 614-638-6705
  • Area of Interest FTICR MS, glycomics, proteomics, PTM characterization

A major focus of my current research lies in the development of an integrated analytical and bioinformatics approach for high-throughput de novo glycan sequencing. We utilize electron activated dissociation (ExD) methods to generate structurally informative tandem mass spectra, both off-line and on-line with various glycan separation methods, including high-performance liquid chromatography (HPLC) and ion mobility spectrometry (IMS) for characterization of complex glycan mixtures. We also carry out theoretical studies of the glycan ExD fragmentation processes, and collaborate with bioinformaticians to develop software tools for spectral interpretation and structural determination.

Another area of my research focuses on direct MS analysis of protein acylation. Reversible S-acylation modulates the protein hydrophobicity and plays an important regulatory role in protein trafficking, membrane localization and cellular signaling. We are developing sample preparation and LC-MS/MS methods for enrichment, preservation and reliable characterization of protein acylation.

  1. Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85. PMID: 26729453.
    View in: PubMed
  2. Taylor WJ, Fransen J, Dalbeth N, Neogi T, Ralph Schumacher H, Brown M, Louthrenoo W, Vazquez-Mellado J, Eliseev M, McCarthy G, Stamp LK, Perez-Ruiz F, Sivera F, Ea HK, Gerritsen M, Scire CA, Cavagna L, Lin C, Chou YY, Tausche AK, da Rocha Castelar-Pinheiro G, Janssen M, Chen JH, Slot O, Cimmino M, Uhlig T, Jansen TL. Diagnostic Arthrocentesis for Suspicion of Gout Is Safe and Well Tolerated. J Rheumatol. 2016 Jan; 43(1):150-3. PMID: 26628602.
    View in: PubMed
  3. Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 1; 7(2):1447-1456. PMID: 26900446.
    View in: PubMed
  4. Yu X, Sargaeva NP, Thompson CJ, Costello CE, Lin C. In-Source Decay Characterization of Isoaspartate and ß-Peptides. Int J Mass Spectrom. 2015 Nov 15; 390:101-109. PMID: 26644780.
    View in: PubMed
  5. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex. J Am Soc Mass Spectrom. 2016 Feb; 27(2):319-28. PMID: 26432580.
    View in: PubMed
  6. Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of S-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9. PMID: 24279456.
    View in: PubMed
  7. Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86. PMID: 24224699.
    View in: PubMed
  8. Yu X, Jiang Y, Chen Y, Huang Y, Costello CE, Lin C. Detailed glycan structural characterization by electronic excitation dissociation. Anal Chem. 2013 Nov 5; 85(21):10017-21. PMID: 24080071.
    View in: PubMed
  9. Yu X, Huang Y, Lin C, Costello CE. Energy-dependent electron activated dissociation of metal-adducted permethylated oligosaccharides. Anal Chem. 2012 Sep 4; 84(17):7487-94. PMID: 22881449.
    View in: PubMed
  10. Li X, Yu X, Costello CE, Lin C, O’Connor PB. Top-down study of ß2-microglobulin deamidation. Anal Chem. 2012 Jul 17; 84(14):6150-7. PMID: 22746280.
    View in: PubMed

Complete list can be found at BU Profiles

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