BU Receives Massachusetts Life Sciences Capital Grant

in Featured, Research
April 30th, 2019

Funding will develop new brain imaging techniques to better understand diseases like CTE, Alzheimer’s

Illustration by lolloj/iStock

There is currently no way to track the subtle brain changes caused by traumatic head injuries or degenerative neurological diseases—but that’s finally poised to change. A $4.9 million grant from the Massachusetts Life Sciences Center (MLSC) has been awarded to the Center for Translation Neurotrauma Imaging (CTNI) at the Boston University School of Medicine. With support from the grant, the CTNI will improve brain imaging techniques and open doors to developing diagnostics and treatments for neurodegenerative diseases.

In addition to the MLSC grant, the CTNI has received additional in-kind donations valued at $6.3 million, and it will collaborate with clinicians and researchers at Boston Medical Center, which has the busiest level 1 trauma and emergency services in the region.

Center codirectors Stephan Anderson and Lee Goldstein say that the CTNI’s efforts will bridge a critical imaging gap and will lead to better clinical care for people with diseases like Alzheimer’s, which is difficult to diagnose in its early stages and currently has no cure. The researchers are also interested in developing imaging techniques to be able to see signs of chronic traumatic encephalopathy (CTE), which cannot yet be detected in living people, but has made news headlines for being found in hundreds of brains from deceased National Football League players and military servicepeople who sustained repetitive hits to the head during their lives.

The gap in imaging technology must be filled before emerging treatments for brain injury can be successfully tested and used clinically in humans, says Goldstein, a MED associate professor of psychiatry, neurology, ophthalmology, pathology and laboratory medicine, and radiology, and a College of Engineering associate professor of biomedical engineering and of electrical and computer engineering.

The CTNI will also research new ultrasound imaging and focused ultrasound applications.

“The use of focused ultrasound is an emerging area in neuroscience, enabling fundamental discoveries in neurotrauma as well as the potential development of novel, acoustically enabled therapeutics,” says Anderson, a MED professor of radiology and an ENG professor of mechanical engineering and a faculty member of both the Nanotechnology Innovation Center and the Photonics Center.

MLSC received 45 applicants for grants, ultimately awarding a total of $30.5 million to 11 proposals. The MLSC Competitive Capital Program is designed to provide grants for capital projects that support the life sciences ecosystem in Massachusetts by enabling and supporting life sciences workforce development and training, research and development, commercialization, and/or manufacturing in the commonwealth.

This BU Today story was written by Gina Digravio.