BU-Led Research Maps the Route to Dementia: Largest-ever study of chronic traumatic encephalopathy » BU today CSTE 3

The brain of Ron Perryman shows moderate p-tau pathology involving multiple regions of brain diagnostic of stage II-III CTE. In addition, there is widespread deposition of abnormal TDP-43 protein around small blood vessels and in the cerebral cortex. These changes together with loss of anterior horn cells of the spinal cord and degeneration of the cortical spinal tracts indicate the presence of CTE plus motor neuron disease (CTE-MND). Photo by Ann C. McKee

The brain of Ron Perryman shows moderate p-tau pathology involving multiple regions of brain diagnostic of stage II-III CTE. In addition, there is widespread deposition of abnormal TDP-43 protein around small blood vessels and in the cerebral cortex. These changes together with loss of anterior horn cells of the spinal cord and degeneration of the cortical spinal tracts indicate the presence of CTE plus motor neuron disease (CTE-MND). Photo by Ann C. McKee

Figure 10. Ron Perryman.The brain of Ron Perryman shows moderate p-tau pathology involving multiple regions of brain diagnostic of stage II-III CTE. In addition, there is also widespread deposition of abnormal TDP-43 protein around small blood vessels and in the cerebral cortex. These changes together with loss of anterior horn cells of the spinal cord and degeneration of the cortical spinal tracts indicate the presence of CTE plus motor neuron disease (CTE-MND). Photo by Ann C McKee, MD, VA Boston/Boston University School of Medicine.