Zaia Research Group
Our research focuses on glycoprotein and proteoglycan biochemistry using mass spectrometry as the primary tool .
Matrisome glycoproteins and proteoglycans provide the microenvironment for brain cells. Because these molecules are highly glycosylated and heterogeneous, there is little understanding of the structural changes that occur in brain diseases. We are building maps matrisome molecular structure related to normal brain physiology and diseases including schizophrenia, drug abuse, Parkinson’s disease.
Viral glycoproteins recognize host cell surfaces and mediate host-viral membrane fusion. Despite the availability of genetic sequencing and X-ray structural data, there is little understanding of the mature structures of viral glycoproteins. We are developing workflows for viral glycoproteomics and applying them to influenza A glycoproteins.