Graduate student position open
We are recruiting a graduate student to work on a new NIH-supported project in the Zaia group at Boston University.
Alzheimer’s disease is the most common cause of dementia and a serious economic burden. While cerebrovascular integrity is essential for brain metabolism, its dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease. The goal of this project is to elucidate the functional interplay between cerebrovascular remodeling and Alzheimer’s disease progression. The hypothesis is that structural and functional alterations in cerebrovasculature is correlated with neurodegeneration. Working in a multidisciplinary team, we are correlating vascular mechanobiology, optical imaging, neuropathology, glycomics and proteomics in an effort to discover new molecular mechanisms and treatment options for Alzheimer’s disease.
We seek a graduate student with interest in glycomics and proteomics for this project. The project will involve quantitative glycomics and proteomics of cerebrovasculature. The postdoctoral scientist will conduct brain tissue sample preparation and glyco/proteomics LC-MS experiments. S/He will work within a collaborative team including mechanobiologists, biochemists, analytical chemists, bioinformaticians and neuropathologists to develop and validate a statistically rigorous changes to cerebrovascular glyco/protein structure that occur during Alzheimer’s disease progression.
See our recent article on glycomics and proteomics of Parkinson’s disease.
Interested? Please contact Joe Zaia