Konstantin Balashov, MD, PhD, FAAN

Clinical Professor of Neurology Director, Multiple Sclerosis Center

  • Title Clinical Professor of Neurology
    Director, Multiple Sclerosis Center
  • Office Shapiro Building, 725 Albany St., 7th floor, Boston, MA 02118
  • Phone 617-638-8456
  • Education Medical School: Russian State Medical University (MD)
    Internship: Brooklyn Hospital Center/Cornell University (Internal Medicine)
    Residency: New Jersey Neuroscience Institute/Seton Hall University (Neurology)
    Fellowship: Brigham and Women’s Hospital/Harvard Medical School (Multiple Sclerosis/Neuroimmunology)

Board Certifications: Neurology (American Board of Psychiatry and Neurology), Neuroimaging (United Council for Neurologic Subspecialties)

Special Interests: Multiple Sclerosis

Conducts Clinical Trials: Yes

Selected Publications

Balashov, K.E., Hafler, D.A., Khoury, S.J., and H.L.Weiner. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest 1995; 95: 2711-2719.

Balashov, K.E., Smith, D.R., Khoury, S.J., Hafler, D.A., and H.L.Weiner. Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci USA 1997; 94: 599-603.

Smith, D.R., Balashov, K.E., Hafler, D.A., Khoury, S.J., and H.L.Weiner. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased IL-4 production and associated eosinophilia. Ann Neurol 1997; 42: 313-318.

Pohl-Koppe, A., Balashov, K.E., Steere, A.C., Logigan, E.L., and D.A.Hafler. Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. J Immunol 1998; 160: 1804-1810.

Comabella, M., Balashov, K., Issazadeh, S., Smith, D., Weiner, H.L., and S.J.Khoury. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J Clin Invest 1998; 102: 671-678.

Balashov, K.E., Olek, M.J., Smith, D.R., Khoury, S.J., and H.L.Weiner. Seasonal variation of IFN-gamma production in progressive multiple sclerosis. Ann Neurol 1998; 44: 824-828.

Balashov, K.E., Rottman, J.B., Weiner, H.L., and W.W.Hancock. CCR5+ and CXCR3+T cells are increased in multiple sclerosis and their ligands MIP-1-alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci USA 1999; 96: 6873-6878.

Balashov, K.E., Comabella, M., Ohashi, T., Khoury, S.J., and H.L.Weiner. Defective regulation of IFN-gamma and IL-12 by endogenous IL-10 in progressive MS. Neurology 2000; 55: 192-198.

Vaknin-Dembinsky, A., Balashov, K., and H.L.Weiner. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol 2006; 176: 7768-7774.

Balashov, K.E., Pal, G., and M.L. Rosenberg. Optic neuritis incidence is increased in spring months in patients with asymptomatic demyelinating lesions. Multiple Sclerosis 2010; 16: 252-4. (PMCID: PMC2861653)

Aung, L.L., Fitzgerald-Bocarsly, P., Dhib-Jalbut, S., and K. E. Balashov, Plasmacytoid dendritic cells in multiple sclerosis: Chemokine and chemokine receptor modulation by interferon-beta. J Neuroimmunol 2010, 226(1-2):158-64 (PMCID: PMC2937086).

Meier, D.S., Balashov, K., Healy, B.C., Weiner, H.L., and C.R.G.  Guttmann.   Seasonal prevalence of MS disease activity. Neurology 2010; 75: 799–806 (PMCID: PMC2938966).

Balashov,K.E., Aung, L.L., Vaknin-Dembinsky, A., Dhib-Jalbut, S., Weiner, H.L. Interferon-beta inhibits Toll-like receptor 9 processing in multiple sclerosis. Ann Neurol 2010; 68: 899-906. (PMCID: PMC3058378)

Balashov, K.E., Aung L., Dhib-Jalbut S., and I.A. Keller. Acute multiple sclerosis lesion: Conversion of restricted diffusion due to vasogenic edema. J Neuroimaging 2011; 21: 202-4 (PMCID: PMC2891920).

Balashov, K.E. and E. Lindzen. Acute demyelinating lesions with restricted diffusion in multiple sclerosis. Multiple Sclerosis Journal 2012; 18(12):1745-53. (PMCID: PMC3576471)

Aung, L.L. and K.E. Balashov. Decreased Dicer expression is linked to increased expression of co-stimulatory molecule CD80 on B cells in Multiple Sclerosis. Multiple Sclerosis Journal 2015; 21: 1131-1138. (PMCID: PMC4457720)

Aung, L.L., Mouradian, M.M., Dhib-Jalbut, S., and K.E. Balashov. MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a. J Neuroimmunology 2015; 278: 185-189. (PMCID: PMC4297694)

Bhise, V., Buyukturkoglu, K., Inglese, M., Wollack, J.B. and K. Balashov. Severe Progressive Brain Atrophy in Pediatric Multiple Sclerosis.  J Pediatr Neuroradiol, 2015, DOI http://dx.doi.org/10.1055/s-0036-1579645.

Balashov, K.E. Imaging of Central Nervous System Demyelinating Disorders. Continuum (American Academy of Neurology) 2016; 5 (Neuroimaging): 1613-1635. PMID: 27740991

Balashov, K.E. Drugs in Development for Multiple Sclerosis. Practical Neurology 2020; 2: 40-44.

Balashov, K., Dhib-Jalbut, S., Rybinnik, I., Fibrinolysis induced clinical improvement in a patient with multiple sclerosis exacerbation. Multiple Sclerosis and Related Disorders, 2020; 43: 102225-102227.

Yadav, S., Ito, N., Mindur, J., Kumar, H., Youssef, M., Suresh, S., Kulkarni, R., Rosario, Y., Balashov, K., Dhib-Jalbut, S., Ito, K. Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in autoimmune neurological disorders. Front Immunol, 2022; 13, https://doi.org/10.3389/fimmu.2022.1015372

Balashov, K., Rosario, Y. Management of Multiple Sclerosis in Pregnancy. In: Neurological Disorders in Pregnancy. G. Gupta et al, (eds). Springer Nature, Cham, Switzerland, pp 325-331, 2023 (ISBN 978-3-031-36489-1).

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