The Website of Mengwei Zang’s Laboratory (Selected Publications)

Selective Original Articles:

  1. Li XY, Kover K, Heruth D, Watkins DJ, Moore WV, Zang M, Clements M, and Yun Yan. New insight into metformin action: regulation of ChREBP and FoXO1 activities in endothelial cells. Molecular Endocrinology, 2015; in press.
  2. Zang M. Targeting AMPK-SREBP nutrient sensing pathway has the therapeutic implication on insulin resistance and metabolic syndrome. Chinese Journal of Diabase Mellitus, 2015; 7: 200-2004.
  3. Li Y, Wong K, Giles A, Lee JW, Jiang J, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology (Impact Factor, 12.50), 2014; 146: 539-549. PMCID: PMC4228483.
  4. Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One, 2013; 8: doi:10.1371. PMCID: 3692453.
  5. Li Y, Wong K, Walsh K, Gao B, Zang M. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. Journal of Biological Chemistry, 2013; 288: 10490-10540, PMCID: 3624431.
  6. Li Y, Xu S, Mihaylova M, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin resistant mice. Cell Metabolism (Impact Factor, 17.350), 2011, 13(4):376-88. PMID: 21459323.  PDF
  7. Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal, 2011, 25(5):1664-79. PMID: 21321189. PDF
  8. Xu S, Jiang B, Hou X, Shi C, Bachschmid M, Zang M, Verbeuren TJ, Cohen RA. High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol. 2011 Jun 3, in press. PMID: 21654327.
  9. Ponugoti B, Xiao Z, Wu S, Chiang C, Zang M, Veenstra TD, Kemper J Kim. SIRT1 deacetylates and inhibits SREBP-1c activity in hepatic lipid metabolic regulation. Journal of Biological Chemistry, 2010; 285: 33959–33970. PMCID: PMC2962496. PDF
  10. Luo Z, Zang M, Wen G. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncology, 2010, 6: 457-470. PMCID: PMC2854547.
  11. Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M, Ren J, Nijland MJ, Ford SP, Nathanielsz PW, Li J. Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB Journal, 2010, 24:2066-2076. PMCID: PMC2874473. PDF
  12. Tao R, Gong J, Luo X, Zang M, Guo W, Wen R, Luo Z. AMPK exerts dual regulatory effects on the PI3K pathway. Journal of Molecular Signaling, 2010, 5:1-9. PMCID: PMC2848036. PDF
  13. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, K. Walsh, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-Activated protein kinase. Journal of Biological Chemistry, 2008, 283: 20015-26. PMCID: PMC2459285. PDF
  14. Zang M, Gong J, Luo L, Zhou J, Xiang X, Huang W, Huang Q, Luo X, Olbrot M, Peng Y, Chen C, Luo Z. Characterization of S338 phosphorylation for Raf-1 activation. Journal of Biological Chemistry, 2008, 283: 31429-37. PMCID: PMC2581588.
  15. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA. Polyphenols stimulate AMP-activated protein Kinase, lower lipids, and inhibit accelerated atherogenesis in diabetic LDL receptor-deficient mice. Diabetes, 2006, 55: 2180-2191. PMID: 16873680.
  16. Zuccollo A, Shi C, Mastroianni R, Maitland KA, Weisbrod RM, Zang M, Xu S, Cayatte A, Corda S, Lavielle G, Verbeuren TJ, Cohen RA. The thromboxane A2 receptor antagonist, S18886, prevents enhanced atherogenesis caused by diabetes mellitus. Circulation, 2005, 112: 3001-3008. PMID: 16260636.
  17. Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. Journal of Biological Chemistry, 2004, 279:47898-47905. PMID: 15371448.
  18. Zang M, Dong M, Pinon DI, Ding X, Hadac EM, Miller LJ. Spatial approximation between a photolabile residue in position 13 of secretin and the amino-terminal tail of the secretin receptor. Molecular Pharmacology, 2003, 63: 993-1001. PMID: 12695527.
  19. Dong M, Li Z, Zang M, Pinon DL, Lybrand TP, Miller LJ. Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Journal of Biological Chemistry, 2003, 278:48300-48312. PMID:14500709.
  20. Xiang X, Zang M, Waelde CA, Wen R, Luo Z. Phosphorylation of S338SYY341 regulates specific interaction between Raf-1 and MEK1. Journal of Biological Chemistry, 2002, 277: 44996-45003. PMID: 12244094.
  21. Zang M, Hayne C, Luo Z. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. Journal of Biological Chemistry, 2002, 277: 4395-4405. PMID: 11733498.
  22. Huang YZ, Zang M, Xiong WC, Luo Z, Mei L. Erbin suppresses the MAP kinase pathway: Down-regulation of AChR epsilon-subunit gene transcription. Journal of Biological Chemistry, 2002, 278, 1108-1114. PMID: 12379659.
  23. Dong M, Zang M, Pinon DI, Li Z, Lybrand TP, Miller LJ. Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. Molecular Endocrinology, 2002, 16: 2490-2501. PMID: 12403838.
  24. Zang M, Waelde CA, Xiang X, Rana A, Wen R, Luo Z. Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. Journal of Biological Chemistry, 2001, 276: 25157-25165. PMID: 11274179.
  25. Dong M, Asmann YW, Zang M, Pinon DI, Miller LJ. Identification of two pairs of spatially approximated residues within the carboxyl-terminus of secretin and its receptor. Journal of Biological Chemistry, 2000; 275: 26032-26039. PMID: 10859300.
  26. Zang M, Meng A, Shen Q, Wang Q, Guo F, Liu JS. NO-cGMP signaling pathway is up-regulated in opiate tolerance and withdrawal. Acta Pharmaceutica Sinica, 2000; 35: 566-570.
  27. Zang M, Shen Q, Sun Y, Wang Q, Liu JS. Mechanisms of opioid receptor-induced elevation in intracellular calcium measured by confocal laser scanning microscopy. Acta Academiae Medicinae Sinicae, 2000; 22: 254-258.
  28. Zang M, Shen Q, Liu JS. Influence of nitric oxide synthase inhibitors on the signaling pathway of opiate tolerance and dependence in NG108-15 cells stably expressing iNOS gene. National Medical Journal of China, 1999; 79: 764-768.
  29. Zang M, Meng A, Sun Y, Liu JS. Modulation of morphine tolerance by N-methyl-D-aspartate receptor antagonist MK801：assessment of opioid receptor and intracellular signaling changes. Chinese Journal of Anesthesiology, 1999; 19: 406-409.
  30. Zang M, Meng A, Shen Q, Sun Y, Wang Q, Liu JS. Blockade of opioid tolerance and dependence by methylene blue. Acta Pharmaceutica Sinica, 1999; 34: 576-581.
  31. Zang M, Shen Q, Wang Q, Guo F, Liu JS. Opiate receptor-mediated activation of adenylate cyclase-cAMP signaling is regulated by inducible nitric oxide synthase in neuronal cells. Acta Pharmaceutica Sinica, 1999; 34: 484-490.
  32. Zang M, Wang Q, Shen Q, Liu JS, Peng XX. Stable expression of recombinant inducible nitric oxide synthase in NG108-15 cells and its biological characterization. Acta Biologiae Experimentalis Sinica, 1999; 33: 335-347.
  33. Zang M, Shen Q, Wang Q, Liu JS. Retrovirus-mediated expression of inducible nitric oxide synthase and its function in neuronal cells. Acta Biochimica et Biophysica Sinica, 1999; 31: 233-238.