THAU Study
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Project Summary
TB, HIV, and Aging in Uganda 50-over-50 (THAU 50/50) is an observational, cross-sectional study that will enroll 50 participants over 50 without a history of TB to compare to 50 participants with a history of TB from the TALC study. This project is a supplement to the TALC study with the long-term goal of providing appropriate interventions for geriatric syndromes and diseases of aging without over-treating older PWH. In Aim 1 of the study, we will determine the association between lifetime alcohol exposure and frailty and explore whether a) aging; b) history of TB disease moderates this association among PWH. In Aim 2 of the study, we will determine the association between social vulnerability and a) aging; b) history of TB disease in PWH. In Aim 3 of the study, we will qualitatively elicit health priorities and opportunities for differentiated healthcare delivery among older PWH with prior TB or unhealthy alcohol use. Participants are invited to complete one in-person study visit that will include assessments and biospecimen collection. The outcomes for aim 1 are frailty index (primary) and frailty phenotype (secondary). The outcome for aim 2 is social vulnerability index.
Funded by the National Institute on Alcohol Abuse and Alcoholism (P01AA029541-03S1)