TALC Study
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Project Summary
The Tuberculosis, Alcohol, and Lung Comorbidities (TALC) study aims to investigate hazardous drinking as a modifiable risk factor for post-TB lung disease in PWH through a 18-month observational study of 200 people with HIV (PWH) completing TB treatment in Mbarara, Uganda. In Aim 1 of the study, we will determine the relationship between hazardous drinking (1-year Alcohol Use Disorders Identification Test > 8) and post-TB lung disease, a group of physiological and anatomical lung deficits, in PWH. In Aim 2 of the study, we will qualitatively evaluate factors for tailoring pharmaco-behavioral alcohol and smoking interventions in PWH being treated for TB. Recruitment for this study began in October 2023. Participants are recruited during their normal clinic visit for TB treatment at the Mbarara City Council Health Centre 4 (MCC HC4) in Mbarara, Uganda. Participants are invited to participate in 6 in-person study visits (baseline, 3-, 6-, 9-, 12-, 15-, 18-month visits) involving assessments and biospecimen collection. The primary outcome for this study and Aim 1 is a 6-minute walk distance. Secondary outcomes include FEV1 (forced expiratory volume in the first second), FVC (forced vital capacity), DLCO (diffusing capacity for carbon monoxide), altered lung anatomy, and respiratory symptom score.
Funded by the National Institute on Alcohol Abuse and Alcoholism (P01AA029541)