- Title Ph.D. student
- Education B. Sc. Neuroscience, McGill University
M. Sc. Neuroscience, McGill University
- Office Grishok Lab, K425
- Email firstname.lastname@example.org
- Area of Interest Genetics, Epigenetics, Histones, Aging
Thomas graduated from McGill University with a B. Sc. in Neuroscience where he tested candidate neural substrates of memory in Aplysia in Dr. Wayne Sossin’s lab and a M. Sc. in Neuroscience where he characterized the effect of disruptions of mitochondrial dynamics on stress resistance and investigated the tissue-specific effects of mitochondrial reactive oxygen species on longevity in C. elegans.
He is once again picking worms as a PhD student in Dr. Alla Grishok’s lab in the Department of Biochemistry. He is working in C. elegans to dissect pathways of RNA interference regulated by the histone methyltransferase DOT-1.1. He is currently performing small RNA sequencing to further characterize dot-1.1 mutants. He is also investigating the intersection between RNA interference and aging.
Meraş İ, Chotard L, Liontis T, Ratemi Z, Wiles B, Seo J, Van Raamsdonk J, Rocheleau C (Preprint) The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes. June 4, 2021 (cited November 11, 2021). Available from: https://doi.org/10.1101/2021.06.04.447106
Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D …, Liontis T, … Fülöp T. (2020) “Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. ” Mechanisms of ageing and development, 191, 111316. https://doi.org/10.1016/j.mad.2020.111316
Machiela E*, Liontis T*, Dues D*, Rudich P, Traa A, Wyman L, Kaufman C, Cooper J, Lew L, Nadarajan S, Senchuk M, Van Raamsdonk J (2020) Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. The FASEB Journal 34:8475-8492. https://doi.org/10.1096/fj.201903235R
*: equal contribution