Congratulations to Nabil Rabhi who was recently awarded a competitive dKNET New Investigator Pilot Program in Bioinformatics Grant. This project addresses how maternal obesity impacts offspring adipose tissue cellular heterogeneity. The project will leverage the recent technological advances in single-cell and spatial transcriptomic and epigenomic to investigate how maternal metabolic status affects the composition and the function of cell types that compose adipose tissue (AT). It will uncover how maternally inherited alterations in AT cellular diversity increases progenies’ susceptibility to weight gain. CRISPR in combination with single-cell sequencing will be used to identify potential regulators of various cell states and uncover causal networks and elucidate molecular mechanisms leading to transgenerational inheritance of obesity.