- Title Postdoctoral Associate – Saeed Lab
- Education Ph. D. -Virus Research, Department of Preventive Veterinary Medicine, Huazhong Agricultural university, Wuhan, China
B. V. M. -Department of Veterinary Medicine, College of Veterinary Medicine, Jiangxi agricultural university, Nan Chang, Jiangxi - Office #502, NIEDL
- Email janeding@bu.edu
- Area of Interest Virology and immunology
I am currently a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed at the Department of Biochemistry and the National Emerging Infectious Diseases Laboratories (NEIDL) of Boston University.
For my Ph.D. degree in Preventive Veterinary Medicine at Huazhong Agricultural University, I studied the molecular details of how animal coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) evade host innate immune responses. In addition, I employed proteomics, RNA sequencing, and advanced molecular biology approaches to probe the mechanisms through which gastrointestinal coronaviruses caused severe inflammation.
I joined the Saeed lab in September 2022. One of my ongoing projects is to explore the function of SARS-CoV2 ORF9b in virus infected cells. Both host and viral targets of ORF9b were identified by employing proximity-based protein labeling and immunoprecipitation coupled with Mass spectrometry. I am deciphering the mechanism and contribution of ORF9b to pathogenesis by employing molecular biology approaches, based on the targets interacted with ORF9b. This research will provide a mechanistic basis for SARS-CoV-2 pathogenesis.
Another project is focus on dissecting the ways in which 2A protease of enteroviruses, such as coxsackieviruses, blunt the interferon response pathway in virus-infected cells. To answer this question, my research is utilizing systems-level strategies, including degradomics and proximity-based protein labeling. These studies are expected to provide unparalleled insights into the enterovirus biology.