- Title Postdoctoral Associate – Saeed Lab
- Education Ph. D. -Virus Research, Department of Preventive Veterinary Medicine, Huazhong Agricultural university, Wuhan, China
B. V. M. -Department of Veterinary Medicine, College of Veterinary Medicine, Jiangxi agricultural university, Nan Chang, Jiangxi - Office NIEDL
- Email janeding@bu.edu
- Area of Interest 1. Interaction between virus infection and cell host response.
2. Screening drugs for anti-virus and therapies for immunopathogenic damage.
3. The pathology research of RNA virus.
4. The function of virus encoded proteins.
I am currently a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed at the Department of Biochemistry and the National Emerging Infectious Diseases Laboratories (NEIDL) of Boston University.
For my Ph.D. degree in Preventive Veterinary Medicine at Huazhong Agricultural University, I studied the molecular details of how animal coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) evade host innate immune responses. In addition, I employed proteomics, RNA sequencing, and advanced molecular biology approaches to probe the mechanisms through which gastrointestinal coronaviruses caused severe inflammation.
I joined the Saeed lab in September 2022. My current focus is on dissecting the ways in which 2A protease of enteroviruses, such as poliovirus and coxsackieviruses, blunt the interferon response pathway in virus-infected cells. To answer this question, my research is utilizing systems-level strategies, including degradomics and proximity-based protein labeling. These studies are expected to provide unparalleled insights into the enterovirus biology and open up avenues for the development of better disease management strategies.
In the future, I will also be involved in a project exploring the mechanisms that underlie SARS-CoV-2-mediated immune dysregulation. To this end, we will utilize advanced multiplex imaging technologies and suitable animal models. An in-depth understanding of how SARS-CoV-2 impairs immune signaling will pave the way for the development of better treatment regimens.