- Title PhD Student – Grishok Lab
- Education BSc. Neuroscience, McGill University
MSc. Neuroscience, McGill University - Office Grishok Lab, K425
- Email tliontis@bu.edu
- Area of Interest Aging, Genetics, Epigenetics, Bioinformatics
Thomas graduated from McGill University with a B. Sc. in Neuroscience where he tested candidate neural substrates of memory in Aplysia in Dr. Wayne Sossin’s lab and a M. Sc. in Neuroscience where he characterized the effect of disruptions of mitochondrial dynamics on stress resistance and investigated the tissue-specific effects of mitochondrial reactive oxygen species on longevity in C. elegans.
He is once again picking worms as a PhD student in Dr. Alla Grishok’s lab in the Department of Biochemistry. He is working in C. elegans to dissect pathways of RNA interference regulated by the histone methyltransferase DOT-1.1. He is currently performing small RNA sequencing to further characterize dot-1.1 mutants. He is also investigating the intersection between RNA interference and aging.
Publications
- Liontis T, Verma K, Grishok A. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. BBA Adv. 2023 Feb 1;3:100080. https://doi.org/10.1016/j.bbadva.2023.100080
- Meraş İ, Chotard L, Liontis T, Ratemi Z, Wiles B, Seo JH, Van Raamsdonk JM, Rocheleau CE. The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan. PLoS Genet. 2022 Aug 1;18(8):e1010328. https://doi.org/10.1371/journal.pgen.1010328
- Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, … , Liontis T, … , Fülöp T. (2020) “Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. ” Mechanisms of ageing and development, 191, 111316. https://doi.org/10.1016/j.mad.2020.111316
- Machiela E*, Liontis T*, Dues D*, Rudich P, Traa A, Wyman L, Kaufman C, Cooper J, Lew L, Nadarajan S, Senchuk M, Van Raamsdonk J (2020) Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. The FASEB Journal 34:8475-8492. https://doi.org/10.1096/fj.201903235R
*: equal contribution
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