- Title Postdoctoral Associate – Zaia Lab
- Education PhD, National Taiwan University of Science and Technology, Taipei, Taiwan
MSc, Addis Ababa University, Addis Ababa, Ethiopia
BSc, Hawassa University, Hawassa, Ethiopia - Office 670 Albany st., 5th floor, Zaia lab
- Email eliasgm@bu.edu
- Area of Interest Glycobiology
Glycosaminoglycans
Mass Spectrometry
Nanomaterials
My expertise lies in the area of mass spectrometry (MS)-based glycomics, glycoproteomics, and metabolomics. As part of my Ph.D. study, I developed a nanoparticle-assisted MALDI-TOF MS method for simultaneous glycan separation and structural elucidation. This method was applied to structure analysis including isomeric differentiation of Lewis glycans and human milk oligosaccharides (HMOs). I began my postdoctoral research at the Institute of Chemistry, Academia Sinica, Taiwan in 2020. The goal of my postdoctoral fellowship was to resolve the structure of a low-molecular-weight heparin anticoagulant drug that was purified by a bioengineered vaccinium virus envelope protein. For selective enrichment of low-abundance endogenous porphyrins and N-linked glycopeptides, I also designed and fabricated different affinity probes decorated magnetic nanoparticles.
Currently, I hold a postdoctoral associate position in Prof. Joseph Zaia’s laboratory. As of now, I am studying glycosaminoglycans (GAGs) using cyclic ion mobility mass spectrometry. As a long-term goal, I plan to develop a method that detects heparan sulfate (HS) at oligosaccharide levels and enriches 3-O-sulfated HS (3-O-SHS) from small-scale laser microdissected tissue samples.
Representative Publications