Biographical information
DENIS LABORATORY — CANCER RESEARCH CENTER
GERALD V. DENIS
Assistant Professor of Medicine and Pharmacology
Scientific co-Director, Flow Cytometry Core, Boston University Medical Campus
Education
Harvard College (A.B.)
University of Tokyo (M.Sc.)
University of California, Berkeley (Ph.D.)
Positions
1979–1981 Research assistant with Dr. Richard Wilson, Department of Physics, Harvard University. High Energy Physics Laboratory, Cambridge, MA
1981–1983 Research assistant with Dr. Elizabeth R. Simons, Department of Biochemistry, Boston University School of Medicine, Boston, MA
1983–1985 Research assistant with Dr. Toshiaki Osawa (Seitai Ibutsu Meneki Kagaku Kyoshitsu) University of Tokyo, Faculty of Pharmaceutical Sciences, Tokyo, Japan
1985–1990 Research assistant with Dr. Clinton E. Ballou, Department of Molecular and Cellular Biology, University of California, Berkeley, CA
1991–1996 Postdoctoral Fellow with Dr. Michael R. Green, Program in Molecular Medicine, University of Massachusetts and Howard Hughes Medical Institute, UMMC, Worcester, MA
1997–2000 Instructor in Medicine, Cancer Research Center, Boston University School of Medicine
2000–present Assistant Professor of Medicine, Boston University School of Medicine
2003–present Assistant Professor of Pharmacology, Boston University School of Medicine
2003–present Member and Instructor, Graduate Program in Molecular Medicine, Boston Medical Center
2005–present Hematology Training Program affiliated faculty member, “Research Training Program in Blood Diseases and Resources”, T32 HL07501, BUSM
2006–present Scientific co-Director, Flow Cytometry Core Facility, Boston University Medical Campus
2007 Immunology Training Program affiliated faculty member, “Research Program in Immunology”, T32 AI007309, BUSM
Honors
1983, Tokyo Biochemical Society Scholarship
1984, Yoneyama Rotary Foundation Fellowship, Tokyo
1997, NIH FIRST award
1997, Aid for Cancer Research Award
2004, American Cancer Society Research Scholar Award
2005, Jiler – American Cancer Society Professors Meeting, competitive abstract winner/participant
Recent Presentations
G. V. Denis, M. E. McComb and C. E. Costello (2004). Brd2-containing multiprotein complexes participate in transcriptional control of the mammalian cell cycle. 52nd Annual Conference on Mass Spectrometry and Allied Topics, Nashville, TN.
P. B. Romesser, D. H. Perlman, C. E. Costello, M. E. McComb and G. V. Denis (2005). Mass spectrometry analysis of cell cycle-regulatory transcription complexes in B cells. Proteomics and Bioinformatics, and Systems and Biology Joint Conference, Keystone, CO.
P. B. Romesser, A. Sinha, H. Huang, D. H. Perlman, M. E. McComb, C. E. Costello and G. V. Denis (2005). Novel machines remodel chromatin and recruit transcription factors to control cyclin A transcription in B cells. HUPO Fourth Annual World Congress, Munich, Germany.
G. V. Denis (2005). Novel machines that control cyclin A transcription and the cell cycle through chromatin remodeling and transcription factor recruitment. European Institute of Oncology, Milano, Italy.
P. B. Romesser, D. H. Perlman, A. Sinha, M. E. McComb, D. V. Faller, C. E. Costello and G. V. Denis (2006). The proteomics of proliferation and malignancy: analysis of tumor-specific and proliferation-specific transcription complexes in normal and malignant B cells. 54th Annual Conference on Mass Spectrometry and Allied Topics, Seattle, WA.
H. Y. Luo, R. K. Basran, S. H. Eung, G. V. Denis, M. H. Steinberg and D. H. K. Chui (2006). Does AT?G mutation in a putative GATA-1 binding site 5´ upstream of the ?-globin gene affect the binding of other transcription factors in this region? National Sickle Cell Disease Program, 29 th Annual Meeting, Memphis, TN.
M. Lenburg, A. Sinha, D. V. Faller and G. V. Denis (2007). Tumor-specific and proliferation-specific gene expression typifies murine transgenic (Tg) B cell lymphomagenesis. Keystone Conference on B cells. Banff, Alberta.
H. O. Longe, P. B. Romesser, D. V. Faller, M. S. Eller, B. A. Gilchrest, A. Sinha and G. V. Denis (2007). Telomere DNA-based adjunctive therapy is effective for lymphoid malignancy. AACR Annual Meeting, Los Angeles, CA.
P. B. Romesser, D. Perlman, A. Sinha, M. E. McComb, D. V. Faller, C. E. Costello and G. V. Denis (2007). Differential proteomic characterization of B cell proliferative states: analysis of tumor-specific and proliferation-specific proteomes in normal and malignant B cells. 55th Annual Conference on Mass Spectrometry, Indianapolis, IN.
Recent Publications
Denis, G. V., C. Vaziri, N. Guo and D. V. Faller (2000). RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Diff. 11: 417 – 424.
Guo, N., D. V. Faller and G. V. Denis (2000). Activation-induced nuclear translocation of RING3. J. Cell Sci. 113: 3085 –3091.
Denis, G. V. (2001). Duality in bromodomain-containing protein complexes. Front. Biosci. 6: D849-52.
Denis, G. V. (2001). Bromodomain motifs and “scaffolding”? Front. Biosci. 6: D1065-8.
Denis, G. V., Q. Yu, P. Ma, L. Deeds, D. V. Faller and C.-Y. Chen (2003). Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial ras. J. Biol. Chem. 278: 5775 – 5785.
Greenwald R., J. R. Tumang, A. Sinha, N. Currier, R. D. Cardiff, T. L. Rothstein, D. V. Faller and G. V. Denis (2004). E(mu)-BRD2 transgenic mice develop B cell lymphoma and leukemia. Blood 103: 1475 – 1484.
Sinha, A., D. V. Faller and G. V. Denis (2005). Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem. J. 387: 257 – 269.
Longe, H., D. V. Faller and G. V. Denis (2005). Telomere-based pre-clinical therapy in a murine model of non-Hodgkin’s lymphoma of the diffuse large B cell (DLCL) type. Blood 106: 607.
Denis, G. V., M. E. McComb, D. V. Faller, A. Sinha, P. B. Romesser and C. E. Costello (2006). Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J. Proteome Res. 5: 502 – 511.
You, J., V. Srinivasan, G. V. Denis, W. J. Harrington Jr , M. E. Ballestas, K. M. Kaye and P. M. Howley (2006). The Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J. Virol. 80: 8909 – 8919.
Lenburg, M., A. Sinha, D. V. Faller and G. V. Denis (2007). Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J. Biol. Chem. 282: 4803 – 4811.
Longe, H. O., P. B. Romesser, D. V. Faller, M. S. Eller, B. A. Gilchrest, A. Sinha and G. V. Denis (2007). Telomere DNA-based adjunctive therapy is effective for lymphoid malignancy. Proc. Am. Assoc. Cancer Res. 2007: 1216.
Longe, H., D. V. Faller, D. Xu, H. Xu, M. S. Eller, B. A. Gilchrest, A. Sinha, P. Romesser and G. V. Denis (2007). Telomere DNA-based therapy for B cell lymphoma models. In prep.
Sinha, A., D. V. Faller, A. Lerner and G. V. Denis (2007). Aggressive B-1-like lymphomas of E(mu)-BRD2 transgenic mice lack immunoglobulin gene diversity. In prep.
Romesser, P. B., D. H. Perlman, C. E. Costello, M. E. McComb, F. Wang and G. V. Denis (2007). Mass spectrometric analysis of cell cycle-regulatory transcription complexes in B cells. In prep.
Wang, F., N. K. LeBrasseur, D. V. Faller, A. Sinha and G. V. Denis (2007). Brd2 is a key regulator of body energy balance. In prep.
Book Chapters
Denis, G. V. (2007). Imatinib mesylate (Gleevec) and the emergence of chemotherapeutic drug-resistant mutations. In H. L. Kaufman, S. Wadler and K. H. Antman, Eds., Cancer Drug Discovery and Development; Specific Drugs for Molecular Targeting in Oncology, Part IV, Chapter 22. Humana Press; Totowa, NJ. In press.
Research Support
Completed
T32 AI007272 (PI Ennis)
NIH (NIAID): Virus AIDS Pathogenesis and Host Defenses
R29 CA75107 FIRST award (PI Denis)
NIH (NCI): A Novel, Inducible Nuclear Kinase Linked to Leukemia
Cancer Center Pilot Grant (PI Denis)
Cancer Research Center, Boston University School of Medicine
Multiprotein Complexes in the Cell Cycle and Cancer
R03 CA102889 (PI Denis)
NIH (NCI): Biomarkers for Lymphoma in a New Transgenic Mouse Model
Undergraduate Research Opportunity Award (PI Denis)
Boston University: Proteomic Characterization of B cell Proliferative States
Undergraduate Research Opportunity Award
Boston University: Mass Spectrometric Analysis of Cell Cycle-Regulatory Transcription Complexes
Active
RSG-05-072-01 (PI Denis)
American Cancer Society: Molecular Analysis of Brd2 Signaling and B Cell Function
P41 RR010888 (PI Costello)
NIH (NATIONAL CENTER FOR RESEARCH RESOURCES): Mass Spectrometry Resource for Biology and Medicine
R03 CA128006 (PI Denis)
NIH (NCI): Proteomic Biomarkers for Lymphoma
Pilot and Feasibility Award (PI Denis)
Boston Area Diabetes Endocrinology Research Center: The Role of Brd2 in Energy Homeostasis
