– working on analyzing endophenotypes relating to Alzheimer’s Disease. In particular, he is interested in investigating neuroimaging phenotypes and also biomarkers that may be concordant in other neurodegenerative diseases
Dr. Lindsay Farrer’s Lab, Biomedical Genetics
Ph.D. in Bioinformatics, Boston University, Boston, MA (2015- present)
M.S. in Bioinformatics, Boston University, Boston, MA (2014)
B.S. in Biopsychology, Tufts University, Medford, MA (2012)
Genetics and genomics of Alzheimer’s Disease
PhD Candidate in Genetics and Genomics, Boston University School of Medicine
B.S. Biotechnology, Indiana University Bloomington (2012)
- Dissecting the SMAD4 metastasis suppressor complex to identify novel prognostic biomarkers and therapeutic targets in colon cancer
- Identification of miRNA biomarkers for early diagnosis and therapy of triple-negative breast cancer
- Nanoparticles directed to IL13RA2 for targeted therapy of basal-like breast cancer
Honors and Awards
Student Achievement Award (First Prize) – 24th Annual Henry I. Russek Day, BUSM
2016 – 2018
Mentoring and Training in Cancer Health Disparities (MATCH) Fellowship – Susan G. Komen Foundation
Student Achievement Award (Second Prize) – 23rd Annual Henry I. Russek Day, BUSM
2016 – 2017
BUnano Cross-Disciplinary Fellowship
Student Achievement Award (Third Prize) – 22nd Annual Henry I. Russek Day, BUSM
2015 – 2016
Cross-Disciplinary Training in Nanotechnology for Cancer Fellowship, Boston University
Phi Beta Kappa
Founders Scholar, Indiana University Bloomington
Service and Leadership
Creative Director –Minority and International Scientists Organization, BUSM
Student Representative-Biomedical Genetics Section, BUSM
Volunteer-BU CityLab Scholars
Course Tutor “Structure and Function of the Genome” – Graduate Medical Sciences, BUSM
- Ozturk S, Wong CK, Papageorgis P, Lambert AW, Abdolmaleky HM, Thiagalingam A, Cohen HT, and Thiagalingam S (2016) SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proceedings of the National Academy of Sciences. 113: 638-43.
- Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, and Thiagalingam S (2016) Periostin regulates cytokine production to maintain breast cancer stem cells. Molecular Cancer Research. 14: 103-13.
- Papageorgis P, Ozturk S, Lambert AW, Neophytou CM, Tzatsos A, Wong CK, Thiagalingam S, and Constantinou AI (2015) Targeting IL13RA2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis. Breast Cancer Research. 17.
- Li W, Kuzoff R, Wong CK, Tucker A, and Lynch M (2014) Characterization of newly gained introns in Daphnia populations. Genome Biology and Evolution. 6: 2218-34
- Abdolmaleky HM, Nohesara S, Ghadirivasfi M, Lambert AW, Ozturk S, Wong CK, Shafa R, and Thiagalingam S (2013) DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. Schizophrenia Research. 152: 373-80.
Ph.D in Genetics and Genomics, Boston University School of Medicine (2015-present)
B.S. Pharmacology, Sichuan University, West China School of Pharmacy
M.S. in Pharmacology and Experimental Therapeutics, Tufts University School of Biomedical Sciences
Use machine learning methods to understand the potential environmental factors that could contribute to drug cessation, furthermore, I’m working on combining the human genetic data with featured environmental factors to evaluate drug cessation outcome. In the end, mouse model and RNA-seq analysis will be used to find the converging evidence between mouse and human.
She is interested in using bioinformatics tools to understand addiction. Her project involves in interpreting and translating the genetic inherited information from mouse addictive traits and human population. Jiayi finished her TTPAS training program focusing on addiction research in December 2016.
- Stacey L. Kirkpatrick, Lisa R. Goldberg, Neema Yazdani, R. Keith Babbs, Jiayi Wu, Eric R. Reed, David F. Jenkins, Amanda Bolgioni, Kelsey I. Landaverde, Kimberly P. Luttik, Karen S. Mitchell, Vivek Kumar, W. Evan Johnson, Megan K. Mulligan, Pietro Cottone, Camron D. Bryant. Cytoplasmic FMR1-Interacting Protein 2 is a Major Genetic Factor Underlying Binge Eating. Biological Psychiatry, 2016; DOI: 10.1016/j.biopsych.2016.10.021
- Jiayi Wu, Devanshi Patel, Jaeyoon Chung, Samantha Lent, Virginia Fisher, Achilleas Pitsillides, Lindsay Farrer, Xiaoling Zhang.(Submitted) An Efficient Analytic Approach in Genome-wide Identification of Methylation Quantitative Trait Loci Response to Fenofibrate Treatment. GAW20.