Barbara M. Schreiber

Schreiber-Barbara-1Associate Professor
Director of Graduate Studies

Boston University School of Medicine
Silvio Conte Building, K207
72 E. Concord Street
Boston, MA 02118

Phone: 617-638-5094
Lab Phone:
617-638-4132
Fax:
617-638-5339
Email:
schreibe@bu.edu

Education

BA, Biology, State University of New York at Buffalo, Buffalo, NY
PhD, Microbiology, Boston University, Boston, MA

People

Larry Pessolano
Graduate Student
Christopher Bishop
Undergraduate Student

Research Interests

Research focuses on studying aortic smooth muscle cells and their role in atherosclerosis. The development of the disease is clearly associated with a chronic inflammation and the laboratory studies the role of inflammation on aortic smooth muscle cell function. A major focus has been studying acute phase serum amyloid A and smooth muscle cell lipid metabolism. Most recently, efforts have been directed at evaluating the role of periodontal disease on the vasculature with an eye toward poor birth outcomes. The lab relies on in vitro approaches (cell culture, immunohistochemistry and molecular biology) and in vivo mouse models of restenosis/atherosclerosis and periodontal disease.

Research Themes

ECM/Cellular Injury
Metabolism, Obesity/Diabetes
Development

Representative Publications

Pubmed Search

  • Trafficking of Endogenous Smooth Muscle Cell Cholesterol: A Role for Serum Amyloid A and Interleukin-1ß. Pessolano LG Jr, Sullivan CP, Seidl SE, Rich CB, Liscum L, Stone PJ, Sipe JD, Schreiber BM. Arterioscler Thromb Vasc Biol. 2012 Sep 20. [Epub ahead of print]
  • Sullivan, C.P., Seidl, S., Rich, C.B., Raymondjean, M., and Schreiber, B.M. Secretory phospholipase A2, group IIA is a novel serum amyloid a target gene; Activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J. Biol. Chem. published 22 October 2009, 10.1074/jbc.M109.070565
  • Johnson, R. J., Williams, J. M., Schreiber, B. M., Elfe, C. D., Lennon-Hopkins, K. L., Skrzypek M. S. and White, R. D.  Analysis of Gene Ontology features in microarray data using the Proteome BioKnowledge® Library. In Silico Biol. 5, 0035, 2005.
  • Hofmann, C. S., Wang, X., Sullivan, C. P., Toselli, P., Stone, P. J., McLean, S. E., Mecham, R. P., Schreiber, B. M. and Sonenshein, G. E.  B-Myb represses elastin gene expression in aortic smooth muscle cells.  J. Biol. Chem., 280:7694-701, 2005.
  • Hofmann, C.S., Sullivan, C.P., Jiang, H.-Y., Stone, P.J., Toselli, P., Reis, E.D., Chereshnev, I., Schreiber, B.M.* and Sonenshein, G.E.*  B-Myb represses vascular smooth muscle cell collagen gene expression and inhibits neointima formation following arterial injury.  Arterioscler. Thromb. Vasc. Biol., 24:1608-13, 2004.
  • Schreiber, B.M.  Serum amyloid A; in search of function.  Amyloid: J. Protein Folding Disord. 9: 276-278, 2002.
  • Zhao, D., Letterman, J. and Schreiber, B.M. ßVLDL activates smooth muscle cell MAP kinase via G protein-coupled receptor-mediated transactivation of the EGF receptor: Effect of MAP kinase activation on ßVLDL plus EGF-induced cell proliferation. J. Biol. Chem. 276:30579-88, 2001.
  • Schreiber, B.M., Veverbrants, M., Fine, R.E., Blusztajn, J.K., Salmona, M., Patel, A., and Sipe, J.D. Apolipoprotein serum amyloid A (SAA) down regulates smooth muscle cell lipid biosynthesis. Biochem. J. 344:7-13, 1999.
  • Hsiao, H., Stone, P.J., Toselli, P., Rosenbloom, J., Franzblau, C., and Schreiber, B.M. The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber. Conn. Tiss. Res. 40:83-95, 1999.
  • Kumon, Y., Sipe, J.D., Brinckerhoff, C.E., and Schreiber, B.M. Regulation of extrahepatic SAA gene expression by interleukin-1a alone: synthesis and secretion of the apolipoprotein serum amyloid A (apo SAA) by cultured aortic smooth muscle cells. Scand. J. Immunol. 46:284-291, 1997.